scholarly journals Current Insights into the Management of Late Chemotherapy Toxicities in Pediatric Osteosarcoma Patients

2021 ◽  
Vol Volume 13 ◽  
pp. 8989-8998
Author(s):  
Stefanie Hecker-Nolting ◽  
Thorsten Langer ◽  
Claudia Blattmann ◽  
Leo Kager ◽  
Stefan S Bielack
Keyword(s):  
Pediatric Osteosarcoma

Immunotherapeutic approaches in pediatric osteosarcoma

2018 ◽  
Vol 70 (6) ◽  
Author(s):  
Hui Cao ◽  
Hongwei Zhang ◽  
Huaxin Zou
Keyword(s):  
Pediatric Osteosarcoma

Identifying the Molecular Cause of Extreme Endoplasmic Reticulum Dilation in Pediatric Osteosarcoma and Its Relationship to the Disease

2021 ◽  
Author(s):  
◽  
Rachael Wood ◽  
Keyword(s):  
Endoplasmic Reticulum ◽  
Genomic Instability ◽  
Cell Lines ◽  
Molecular Signature ◽  
Osteosarcoma Cell ◽  
Copii Vesicle ◽  
Molecular Therapeutic ◽  
Molecular Therapeutic Targets ◽  
Pediatric Osteosarcoma ◽  
Crispr Activation

Pediatric osteosarcoma tumors are characterized by an unusual abundance of grossly dilated endoplasmic reticulum and an immense genomic instability that has complicated identifying new effective molecular therapeutic targets. Here we report a novel molecular signature that encompasses the majority of 108 patient tumor samples, PDXs and osteosarcoma cell lines. These tumors exhibit reduced expression of four critical COPII vesicle proteins that has resulted in the accumulation of procollagen-I protein within ‘hallmark’ dilated ER. Using CRISPR activation technology, increased expression of only SAR1A and SEC24D to physiologically normal levels was sufficient to restore both collagen-I secretion and resolve dilated ER morphology to normal.

scholarly journals In silico functional analyses and discovery of survivalassociated microRNA signatures in pediatric osteosarcoma

Oncoscience ◽  
2014 ◽  
Vol 1 (9) ◽  
pp. 599-608 ◽  
Author(s):  
Patricia C. Sanchez-Diaz ◽  
Tzu-Hung Hsiao ◽  
Yi Zou ◽  
Aaron J. Sugalski ◽  
Josefine Heim-Hall ◽  
...  
Keyword(s):  
In Silico ◽  
Functional Analyses ◽  
Pediatric Osteosarcoma

Superior Survival in Treatment of Primary Nonmetastatic Pediatric Osteosarcoma of the Extremity

2003 ◽  
Vol 10 (5) ◽  
pp. 498-507 ◽  
Author(s):  
Ross M. Wilkins ◽  
John W. Cullen ◽  
Lorrie Odom ◽  
Brandt A. Jamroz ◽  
Patsy McGuire Cullen ◽  
...  
Keyword(s):  
Pediatric Osteosarcoma

Tumor Necrosis in Pediatric Osteosarcoma: Impact of Modern Therapies

2006 ◽  
Vol 23 (4) ◽  
pp. 176-181 ◽  
Author(s):  
Eleanor Hendershot ◽  
Alberto Pappo ◽  
David Malkin ◽  
Lillian Sung
Keyword(s):  
Tumor Necrosis ◽  
Pediatric Osteosarcoma

Abstract 2532: Pediatric osteosarcoma patients are taller than average from birth to age twelve: a report from the Children's Oncology Group.

2013 ◽  
Author(s):  
Logan G. Spector ◽  
Kathryn Ritter ◽  
Ellen W. Demerath ◽  
Charles Sklar ◽  
Julie A. Ross ◽  
...  
Keyword(s):  
Oncology Group ◽  
Pediatric Osteosarcoma

scholarly journals Clinicopathological Profile And Outcomes Of Pediatric Osteosarcoma From A Tertiary Care Oncology Center

2018 ◽  
Vol 3 (3) ◽  
pp. S53-S54
Author(s):  
Pooja Gujjal Chebbi ◽  
M. Padma ◽  
B.S. Arunakumari ◽  
A.R. Arunkumar ◽  
N. Kumar ◽  
...  
Keyword(s):  
Tertiary Care ◽  
Clinicopathological Profile ◽  
Oncology Center ◽  
Pediatric Osteosarcoma
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