pediatric osteosarcoma
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2021 ◽  
pp. molcanther.MCT-21-0565-A.2021
Author(s):  
Naiara Martínez-Vélez ◽  
Virginia Laspidea ◽  
Marta Zalacain ◽  
Sara Labiano ◽  
Marc Garcia-Moure ◽  
...  

2021 ◽  
Author(s):  
◽  
Rachael Wood ◽  

Pediatric osteosarcoma tumors are characterized by an unusual abundance of grossly dilated endoplasmic reticulum and an immense genomic instability that has complicated identifying new effective molecular therapeutic targets. Here we report a novel molecular signature that encompasses the majority of 108 patient tumor samples, PDXs and osteosarcoma cell lines. These tumors exhibit reduced expression of four critical COPII vesicle proteins that has resulted in the accumulation of procollagen-I protein within ‘hallmark’ dilated ER. Using CRISPR activation technology, increased expression of only SAR1A and SEC24D to physiologically normal levels was sufficient to restore both collagen-I secretion and resolve dilated ER morphology to normal.


2021 ◽  
Vol Volume 13 ◽  
pp. 8989-8998
Author(s):  
Stefanie Hecker-Nolting ◽  
Thorsten Langer ◽  
Claudia Blattmann ◽  
Leo Kager ◽  
Stefan S Bielack

Cureus ◽  
2021 ◽  
Author(s):  
Megha Suri ◽  
Nitin Soni ◽  
Nkiruka Okpaleke ◽  
Shikha Yadav ◽  
Suchitra Shah ◽  
...  

Cancers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2671
Author(s):  
Byung-Chul Kim ◽  
Jingyu Kim ◽  
Kangsan Kim ◽  
Byung Hyun Byun ◽  
Ilhan Lim ◽  
...  

Chemotherapy response and metastasis prediction play important roles in the treatment of pediatric osteosarcoma, which is prone to metastasis and has a high mortality rate. This study aimed to estimate the prediction model using gene expression and image texture features. 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) images of 52 pediatric osteosarcoma patients were used to estimate the machine learning algorithm. An appropriate algorithm was selected by estimating the machine learning accuracy. 18F-FDG PET/CT images of 21 patients were selected for prediction model development based on simultaneous KI67 and EZRIN expression. The prediction model for chemotherapy response and metastasis was estimated using area under the curve (AUC) maximum image texture features (AUC_max) and gene expression. The machine learning algorithm with the highest test accuracy in chemotherapy response and metastasis was selected using the random forest algorithm. The chemotherapy response and metastasis test accuracy with image texture features was 0.83 and 0.76, respectively. The highest test accuracy and AUC of chemotherapy response with AUC_max, KI67, and EZRIN were estimated to be 0.85 and 0.89, respectively. The highest test accuracy and AUC of metastasis with AUC_max, KI67, and EZRIN were estimated to be 0.85 and 0.8, respectively. The metastasis prediction accuracy increased by 10% using radiogenomics data.


Author(s):  
Nelson Menendez ◽  
Monica Epelman ◽  
Lei Shao ◽  
Dorothea Douglas ◽  
Arthur B. Meyers

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