Clinically relevant concentration of anti-viral drug ribavirin selectively targets pediatric osteosarcoma and increases chemosensitivity

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2018.10.124 ◽

2018 ◽

Vol 506 (3) ◽

pp. 604-610 ◽

Author(s):

Jianguo Chen ◽

Xiaoming Xu ◽

Junjun Chen

Keyword(s):

Relevant Concentration ◽

Pediatric Osteosarcoma

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Immunotherapeutic approaches in pediatric osteosarcoma

Minerva Pediatrica ◽

10.23736/s0026-4946.17.04930-1 ◽

2018 ◽

Vol 70 (6) ◽

Author(s):

Hui Cao ◽

Hongwei Zhang ◽

Huaxin Zou

Keyword(s):

Pediatric Osteosarcoma

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Generational effects of a chronic exposure to a low environmentally relevant concentration of glyphosate on rainbow trout, Oncorhynchus mykiss

The Science of The Total Environment ◽

10.1016/j.scitotenv.2021.149462 ◽

2021 ◽

pp. 149462

Author(s):

Jessy Le Du-Carrée ◽

Rania Boukhari ◽

Jérôme Cachot ◽

Joëlle Cabon ◽

Lénaïg Louboutin ◽

...

Keyword(s):

Rainbow Trout ◽

Oncorhynchus Mykiss ◽

Chronic Exposure ◽

Relevant Concentration ◽

Rainbow Trout Oncorhynchus Mykiss ◽

Generational Effects

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AN ENVIRONMENTALLY RELEVANT CONCENTRATION OF ESTROGEN INDUCES ARREST OF MALE GONAD DEVELOPMENT IN ZEBRAFISH, DANIO RERIO

Environmental Toxicology and Chemistry ◽

10.1897/04-096r1.1 ◽

2005 ◽

Vol 24 (5) ◽

pp. 1088 ◽

Author(s):

Martina Fenske ◽

Gerd Maack ◽

Christoph Schäfers ◽

Helmut Segner

Keyword(s):

Danio Rerio ◽

Gonad Development ◽

Relevant Concentration

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Acute exposure to an environmentally relevant concentration of diclofenac elicits oxidative stress in the culturally important galaxiid fish Galaxias maculatus

Environmental Toxicology and Chemistry ◽

10.1002/etc.3948 ◽

2017 ◽

Vol 37 (1) ◽

pp. 224-235 ◽

Author(s):

Nicole K. McRae ◽

Chris N. Glover ◽

S. Rebekah Burket ◽

Bryan W. Brooks ◽

Sally Gaw

Keyword(s):

Oxidative Stress ◽

Acute Exposure ◽

Relevant Concentration ◽

Galaxias Maculatus

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Role of18F-fluorodeoxyglucose positron emission tomography/computed tomography and magnetic resonance imaging in prediction of response to neoadjuvant chemotherapy in pediatric osteosarcoma

World Journal of Nuclear Medicine ◽

10.4103/wjnm.wjnm_52_18 ◽

2019 ◽

Vol 18 (4) ◽

pp. 378

Author(s):

JehanAhmed Younis ◽

IsmaelMohammed Al Antably ◽

Manal Zamzam ◽

HalaTaha Salem ◽

EmanMohammed Zaki ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Computed Tomography ◽

Emission Tomography ◽

Fluorodeoxyglucose Positron Emission Tomography ◽

Resonance Imaging ◽

Prediction Of Response ◽

Positron Emission ◽

Pediatric Osteosarcoma ◽

Response To Neoadjuvant Chemotherapy ◽

Fluorodeoxyglucose Positron Emission

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Current Insights into the Management of Late Chemotherapy Toxicities in Pediatric Osteosarcoma Patients

Cancer Management and Research ◽

10.2147/cmar.s287908 ◽

2021 ◽

Vol Volume 13 ◽

pp. 8989-8998

Author(s):

Stefanie Hecker-Nolting ◽

Thorsten Langer ◽

Claudia Blattmann ◽

Leo Kager ◽

Stefan S Bielack

Keyword(s):

Pediatric Osteosarcoma

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Influence of a fat-rich diet, folic acid supplementation and a human-relevant concentration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine on the induction of preneoplastic lesions in the rat colon

Archives of Toxicology ◽

10.1007/s00204-012-0819-1 ◽

2012 ◽

Vol 86 (5) ◽

pp. 815-821 ◽

Author(s):

Petra Nicken ◽

Nicole Brauer ◽

Alfonso Lampen ◽

Pablo Steinberg

Keyword(s):

Folic Acid Supplementation ◽

Rat Colon ◽

Preneoplastic Lesions ◽

Acid Supplementation ◽

Relevant Concentration

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Environmentally relevant concentration of chromium activates Nrf2 and alters transcription of related XME genes in liver of zebrafish

Chemosphere ◽

10.1016/j.chemosphere.2018.09.104 ◽

2019 ◽

Vol 214 ◽

pp. 35-46 ◽

Author(s):

Pallab Shaw ◽

Paritosh Mondal ◽

Arindam Bandyopadhyay ◽

Ansuman Chattopadhyay

Keyword(s):

Relevant Concentration

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Clinically relevant concentration of propofol and benzodiazepines did not affect in vitro angiogenesis

Journal of Anesthesia ◽

10.1007/s00540-021-02993-x ◽

2021 ◽

Author(s):

Kazumi Takaishi ◽

Yasusei Kudo ◽

Shinji Kawahito ◽

Hiroshi Kitahata

Keyword(s):

Relevant Concentration ◽

In Vitro Angiogenesis

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Identifying the Molecular Cause of Extreme Endoplasmic Reticulum Dilation in Pediatric Osteosarcoma and Its Relationship to the Disease

10.21007/etd.cghs.2021.0555 ◽

2021 ◽

Author(s):

◽

Rachael Wood ◽

Keyword(s):

Endoplasmic Reticulum ◽

Genomic Instability ◽

Molecular Signature ◽

Osteosarcoma Cell ◽

Copii Vesicle ◽

Molecular Therapeutic ◽

Molecular Therapeutic Targets ◽

Pediatric Osteosarcoma ◽

Crispr Activation

Pediatric osteosarcoma tumors are characterized by an unusual abundance of grossly dilated endoplasmic reticulum and an immense genomic instability that has complicated identifying new effective molecular therapeutic targets. Here we report a novel molecular signature that encompasses the majority of 108 patient tumor samples, PDXs and osteosarcoma cell lines. These tumors exhibit reduced expression of four critical COPII vesicle proteins that has resulted in the accumulation of procollagen-I protein within ‘hallmark’ dilated ER. Using CRISPR activation technology, increased expression of only SAR1A and SEC24D to physiologically normal levels was sufficient to restore both collagen-I secretion and resolve dilated ER morphology to normal.

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