scholarly journals The Prognostic Impact of Preoperative Serum Apolipoprotein A-I in Patients with Esophageal Basaloid Squamous Cell Carcinoma

2021 ◽  
Vol Volume 13 ◽  
pp. 7373-7385
Author(s):  
Ji-Feng Feng ◽  
Jian-Ming Zhao ◽  
Xun Yang ◽  
Liang Wang
2019 ◽  
Vol 8 (4) ◽  
Author(s):  
Thyago Leite Campos de Campos de Araújo ◽  
Júlio Leite de Araújo Júnior ◽  
Emanuelle de Abreu Moreira Vieira

Introdução: No território brasileiro, a localização anatômica com maior incidência de lesões cancerígenas é em cabeça e pescoço. Sendo caracterizadas como mais agressivas, as lesões localizadas na boca e orofaringe. Afetando, principalmente a capacidade de deglutir e mastigar, no bem estar emocional, na dor e na comunicação. Estes efeitos decorrem da própria doença ou tipo e agressividade do tratamento, gradualmente mais deformantes quando mais tardio o diagnóstico. Objetivo: O presente estudo tem por objetivo relatar um caso de carcinoma in sito em cavidade bucal e orofaringe bem como apresentar uma breve revisão de literatura sobre neoplasias malignas de boca e orofaringe de maior frequência bem como caracterizá-lo clinicamente e alertar sobre os benefícios do diagnóstico precoce. Relato de caso: Paciente, 64 anos, feminina, melanoderma, apresentando lesão eritroplásica em soalho lingual, bordo lateral de língua com extensão para palato mole. Tabagista há 46 anos apresentando ao exame de macroscopia fragmento de tecido mole de formato e superfícies irregulares, consistência elástica, coloração branco acastanhada, medindo em conjunto 1,2 x1,0x 0,5 cm. O exame histopatológico revelou Carcinoma “in situ”. Diante do diagnóstico, a paciente foi encaminhada para o tratamento especializado no hospital de referência na região do Cariri. Conclusão: Conclui-se que o exame clínico minucioso da cavidade oral dos pacientes com fatores de risco 2 e/ou que possuam lesões suspeitas é de fundamental importância para profissionais como o Cirurgião-Dentista e Médico.Descritores: Câncer; Boca; Orofaringe; Odontologia.ReferênciasGupta B, Bhattacharyya A, Singh A, Sah K, Gupta V. Basaloid squamous cell carcinoma - A rare and aggressive variant of squamous cell carcinoma: A case report and review of literature. Natl J Maxillofac Surg. 2018;9(1):64-8.Heera R, Ayswarya T, Padmakumar SK, Ismayil P. Basaloid squamous cell carcinoma of oral cavity: Report of two cases. J Oral Maxillofac Pathol. 2016;20(3):545Tomblinson CM, Nagel TH, Hu LS, Zarka MA, Hoxworth JM. Median lingual lymph nodes: prevalence on imaging and potential implications for oral cavity cancer staging. J Comput Assist Tomogr. 2017;41(4):528-34.Varela-Centelles P, López-Cedrun JL, Fernández-Sanromán J, Seone-Romero JM, Santos de Melo N, Álvarez-Nóvoa P  et al. Key points and time intervals for early diagnosis in symptomatic oral cancer: A systematic review. Int J Oral Maxillofac Surg. 2017;46(1):1-10.Jia J, Jia MQ, Zou HX. Lingual lymph nodes in patients with squamous cell carcinoma of the tongue and the floor of the mouth. Head Neck. 2018;40(11):2383-88.Swiecicki PL, Malloy KM, Worden FP. Advanced oropharyngeal squamous cell carcinoma: Pathogenesis, treatment, and novel therapeutic approaches. World J Clin Oncol. 2016;7(1):15-26.Balica NC, Poenaru M, Doroş CI, Baderca F, Preda MA, Iovan VC et al.The management of the oropharyngeal anterior wall cancer. Rom J Morphol Embryol. 2018;59(1):113-19.Dahlstrom KR, Bell D, Hanby D, Li G, Wang LE, Wei Q et al. Socioeconomic characteristics of patients with oropharyngeal carcinoma according to tumor HPV status, patient smoking status, and sexual behavior. Oral Oncol. 2015;51(9):832-38.Bonomo P, Merlotti A, Olmetto E, Bianchi A, Desideri I, Bacigalupo A et al. What is the prognostic impact of FDG PET in locally advanced head and neck squamous cellcarcinoma treated with concomitant chemo-radiotherapy? A systematic review and meta-analysis. Eur J Nucl Med Mol Imaging. 2018;45(12):2122-38.Picard A, Arowas L, Piroth L, Heard I, Ferry T, ORL-HIV-HPV studt group. Head and neck squamous cell carcinoma in people living with HIV in France. Med Mal Infect. 2018;48(8):503-8.


2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Kumiko Sekiguchi ◽  
Takeshi Matsutani ◽  
Tsutomu Nomura ◽  
Nobutoshi Hagiwara ◽  
Akihisa Matsuda ◽  
...  

2021 ◽  
Vol 80 ◽  
pp. 105621
Author(s):  
Fumitaka Endo ◽  
Yuji Akiyama ◽  
Masazumi Onishi ◽  
Noriyuki Uesugi ◽  
Tamotsu Sugai ◽  
...  

BMC Cancer ◽  
2006 ◽  
Vol 6 (1) ◽  
Author(s):  
Grazia Salerno ◽  
Dolores Di Vizio ◽  
Stefania Staibano ◽  
Giampiero Mottola ◽  
Giuseppe Quaremba ◽  
...  

2021 ◽  
pp. 106689692199713
Author(s):  
Jijgee Munkhdelger ◽  
Tomoko Shimooka ◽  
Yoshinori Koyama ◽  
Sadakatsu Ikeda ◽  
Yoshiki Mikami ◽  
...  

There is a lack of knowledge about molecular alterations in basaloid squamous cell carcinoma (BSCC) of the uterine cervix. A 72-year-old woman with a history of previous subtotal hysterectomy and current vaginal bleeding was referred to our hospital. Initially, adenoid cystic carcinoma (ACC) was diagnosed upon cervical cytology and biopsy. Chest imaging showed multiple metastatic lesions in both lungs. The surgical specimen showed BSCC with diffuse p16 immunoreactivity and negativity for S-100, c-kit, and neuroendocrine markers. There was a focal minor ACC component, which could have explained the previous cytology and biopsy diagnosis. Next-generation sequencing with two different panels showed coexisting PIK3CA mutation and NTRK2 fusion with 10 additional variants of unknown significance ( ATR, DAXX, FAM123B, JAK1, KEL, MLL2, NOTCH2, PALB2, POLD1, POLE). The MYB gene fusions were not identified. The patient received chemotherapy with TRK inhibitor larotrectinib and carboplatin, which caused shrinkage of metastatic lung nodules. This is the first report of cervical BSCC with extensive molecular workup, which detected multiple genetic events, including targetable ones, which are potentially implicated in the development of a tumor. The accumulation of data and further studies on this tumor are necessary to define its diagnostic criteria and its clinical and biological behavior.


2009 ◽  
Vol 24 (3) ◽  
pp. 542 ◽  
Author(s):  
Yong Soon Kwon ◽  
Yong Man Kim ◽  
Ga Won Choi ◽  
Young Tak Kim ◽  
Joo-Hyun Nam

2012 ◽  
Vol 5 ◽  
pp. 447-450
Author(s):  
Deviprasad Shetty ◽  
Vijayalakshmi Subramaniam ◽  
Adarsha Herale ◽  
Prema Saldanha ◽  
Mahaveer Jain

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