scholarly journals Comparative cost-effectiveness of a fluticasone-propionate/salmeterol combination versus anticholinergics as initial maintenance therapy for chronic obstructive pulmonary disease

2010 ◽  
pp. 13 ◽  
Author(s):  
Anand Dalal ◽  
Douglas Mapel ◽  
Melissa Roberts ◽  
Hans Petersen ◽  
Christopher Blanchette
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Cost Effectiveness ◽  
Fluticasone Propionate ◽  
Maintenance Therapy ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Comparative Cost

scholarly journals Estimating the Cost-Effectiveness of Fluticasone Propionate for Treating Chronic Obstructive Pulmonary Disease in the Presence of Missing Data

2006 ◽  
Vol 9 (4) ◽  
pp. 227-235 ◽  
Author(s):  
Andrew H. Briggs ◽  
Greta Lozano-Ortega ◽  
Sally Spencer ◽  
Geraldine Bale ◽  
Michael D. Spencer ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Cost Effectiveness ◽  
Missing Data ◽  
Fluticasone Propionate ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
The Cost

Comparative Cost-effectiveness Analysis of Theophylline and Ipratropium Bromide in Chronic Obstructive Pulmonary Disease

CHEST Journal ◽  
1993 ◽  
Vol 103 (3) ◽  
pp. 678-684 ◽  
Author(s):  
Amal Jubran ◽  
Nicholas Gross ◽  
Joe Ramsdell ◽  
Raffi Simonian ◽  
Karl Schuttenhelm ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Cost Effectiveness ◽  
Pulmonary Disease ◽  
Ipratropium Bromide ◽  
Cost Effectiveness Analysis ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Comparative Cost ◽  
Effectiveness Analysis

scholarly journals RS3 ESTIMATING THE COST-EFFECTIVENESS OF FLUTICASONE PROPIONATE FORTREATING CHRONIC OBSTRUCTIVE PULMONARY DISEASE

2005 ◽  
Vol 8 (3) ◽  
pp. 246-247
Author(s):  
A Briggs ◽  
H Wang ◽  
YM Gagnon ◽  
S Spencer ◽  
G Bale ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Cost Effectiveness ◽  
Fluticasone Propionate ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
The Cost

A generic fluticasone propionate and salmeterol dry powder inhaler: Evidence of usability, function, and robustness

2021 ◽  
Vol 42 (1) ◽  
pp. 30-35 ◽  
Author(s):  
Donald P. Tashkin ◽  
Arkady Koltun ◽  
Róisín Wallace
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Fluticasone Propionate ◽  
Healthy Volunteers ◽  
Pulmonary Disease ◽  
Dry Powder Inhaler ◽  
Chemical Degradation ◽  
Chronic Obstructive ◽  
Dry Powder ◽  
Obstructive Pulmonary Disease ◽  
Flow Rates

Background: A generic combination of fluticasone propionate and salmeterol xinafoate inhalation powder in a premetered, multidose, nonreusable inhaler was recently approved. Objective: To assess the performance of the generic device. Methods: Findings from three studies with regard to device usability, function, and robustness were reviewed. Results: In a study to assess device function in patients and healthy volunteers, the generic device was successfully used by patients with asthma and chronic obstructive pulmonary disease who were either dry powder inhaler users or dry powder inhaler‐naive, even though they were not trained beyond being provided the instructions for use. In a study to measure inhaled flow rates generated by patients and healthy volunteers, the generic device consistently simulated the delivery of a full dose of drug, even to patients with severe respiratory disease and reduced inspiratory flow rates. Although the generic device had a slightly higher airflow resistance, this study demonstrated that this difference did not result in any clinically meaningful differences in terms of drug delivery. Pressure drop, a key parameter that drives the fluidization and aerosolization of the powder dose, was found to be comparable between the devices. In an open-label study, the generic device met all U.S. Food and Drug Administration specifications for device robustness after 21.5 days of twice-daily dosing via oral inhalation among 111 participants with asthma or chronic obstructive pulmonary disease. All inhalers tested demonstrated conformity with a pharmacopeia with respect to key quality parameters (assay, delivered dose uniformity, aerodynamic size distribution). There was no evidence of chemical degradation of the active ingredients, nor of microbial or water ingress into the powder, as a result of inhaler use.

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