scholarly journals Pharmacological Management of Urinary Incontinence: Current and Emerging Treatment

2021 ◽  
Vol Volume 13 ◽  
pp. 209-223
Author(s):  
Carlo Gandi ◽  
Emilio Sacco
2014 ◽  
Vol 16 (3) ◽  
pp. 169-177 ◽  
Author(s):  
Sepeedeh Saleh ◽  
Amitabha Majumdar ◽  
Kate Williams

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 2148 ◽  
Author(s):  
Bronagh McDonnell ◽  
Lori Ann Birder

Lower urinary tract symptoms—in particular, storage disorders (for example, urinary incontinence) as well as bladder underactivity—are major health-related problems that increase with age. Yet lower urinary tract symptoms remain under-diagnosed and poorly managed, and incontinence has been cited as the major reason for institutionalization in elderly populations and is one of the most common conditions in primary care practice. Although lifestyle and behavior therapy has been used as a useful treatment regimen for urge incontinence, medications (often used as adjunct) can provide additional benefit. This review will include current therapies used for treatment of urinary incontinence.


1998 ◽  
Vol 4 (3) ◽  
pp. 114-121
Author(s):  
Gordon McMurray ◽  
Alison F Brading

Urinary incontinence (UI) is thought to affect more than one in ten women in the UK. Despite its prevalence the pathology of UI is poorly understood and its pharmacological treatment largely ineffective, surgical intervention remaining the most conventional treatment for many forms of incontinence. However, the possibility of effective drug therapy is an attractive alternative. The present review summarises the mechanisms by which drugs used to treat UI evoke direct effects on the organs of the lower urinary tract, and describes their clinical efficacy. The majority of these drugs act primarily by either reducing bladder pressure, inhibiting unstable contractions, or increasing outlet resistance during the filling process. The most commonly used drugs are anti-muscarinics, although the high incidence of side effects (including an increased residual volume) and the low level of improvement achieved, has heightened the need for the development of other drug therapies. However, due to the lack of information concerning the pathological causes of unstable detrusor contractions and other changes present in UI sufferers, no drugs are available which are specifically targeted at either treating the causative factors or the changes involved in UI. As pathological understanding increases, more effective pharmacological management may be achieved.


2010 ◽  
Vol 20 (4) ◽  
pp. 268-276 ◽  
Author(s):  
A Mathur ◽  
J Browning ◽  
AK Mistri

SummaryUrinary incontinence is a common and under-reported symptom, affecting one in five people, with a higher prevalence in women and those who are elderly. It can have a major impact on physical health and social activity. Initial assessment to categorize symptom type is the key to guiding further therapy. Non-pharmacological (NP) options are preferred as first-line intervention, and if unsuccessful, are followed by anticholinergics, often in combination with NP options. Surgical intervention must be sought where appropriate. However, NP interventions are often not considered due to uncertainty about the evidence-base, perceived difficulty of application and perhaps a lack of awareness of or access to specialist continence services. This article addresses the first of the barriers, summarizing the evidence for various NP interventions, including lifestyle interventions, physical therapies, behavioural therapies and containment options, enabling the reader to formulate an evidence-based opinion and a pragmatic view on the feasibility, efficacy and applicability of the various NP interventions, without automatic recourse to anticholinergic medication in the first instance.


Drugs ◽  
2006 ◽  
Vol 66 (5) ◽  
pp. 591-606 ◽  
Author(s):  
Hashim Hashim ◽  
Paul Abrams

2015 ◽  
Vol 63 (11) ◽  
pp. 2298-2307 ◽  
Author(s):  
Barbara J. Zarowitz ◽  
Carrie Allen ◽  
Terrence O'Shea ◽  
Eric G. Tangalos ◽  
Todd Berner ◽  
...  

2007 ◽  
Vol 177 (4S) ◽  
pp. 453-454
Author(s):  
Rachelle L. Prantif ◽  
William C. de Groat ◽  
Donna J. Haworth ◽  
Ronald J. Jankowski ◽  
Michael B. Chancellor ◽  
...  

2007 ◽  
Vol 177 (4S) ◽  
pp. 25-26
Author(s):  
Simon Kim ◽  
Rodney L. Dunn ◽  
Edward J. McGuire ◽  
John O.L. DeLancey ◽  
John T. Wei

2006 ◽  
Vol 175 (4S) ◽  
pp. 110-110 ◽  
Author(s):  
Robert D. Moore ◽  
John Miklos ◽  
L. Dean Knoll ◽  
Mary Dupont ◽  
Mickey Karram ◽  
...  

2006 ◽  
Vol 175 (4S) ◽  
pp. 110-110
Author(s):  
Christian Gozzi ◽  
Christian Schwentner ◽  
Peter Rehder

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