scholarly journals Simvastatin attenuates radiation-induced salivary gland dysfunction in mice

2016 ◽  
Vol Volume 10 ◽  
pp. 2271-2278 ◽  
Author(s):  
Xinchen Sun ◽  
Xi Yang ◽  
Jiayan Chen ◽  
Xiao-Lin Ge ◽  
Qin Qin ◽  
...  
2011 ◽  
Vol 121 (9) ◽  
pp. 1870-1875 ◽  
Author(s):  
Tsuyoshi Kojima ◽  
Shin-ichi Kanemaru ◽  
Shigeru Hirano ◽  
Ichiro Tateya ◽  
Atsushi Suehiro ◽  
...  

2007 ◽  
Vol 48 (2) ◽  
pp. 47-56 ◽  
Author(s):  
Katsuhiro Takakura ◽  
Sachiko Takaki ◽  
Ienaka Takeda ◽  
Nobuyuki Hanaue ◽  
Yasuhiro Kizu ◽  
...  

2020 ◽  
Vol 9 (12) ◽  
pp. 4095
Author(s):  
Kimberly J. Jasmer ◽  
Kristy E. Gilman ◽  
Kevin Muñoz Forti ◽  
Gary A. Weisman ◽  
Kirsten H. Limesand

Salivary glands sustain collateral damage following radiotherapy (RT) to treat cancers of the head and neck, leading to complications, including mucositis, xerostomia and hyposalivation. Despite salivary gland-sparing techniques and modified dosing strategies, long-term hypofunction remains a significant problem. Current therapeutic interventions provide temporary symptom relief, but do not address irreversible glandular damage. In this review, we summarize the current understanding of mechanisms involved in RT-induced hyposalivation and provide a framework for future mechanistic studies. One glaring gap in published studies investigating RT-induced mechanisms of salivary gland dysfunction concerns the effect of irradiation on adjacent non-irradiated tissue via paracrine, autocrine and direct cell–cell interactions, coined the bystander effect in other models of RT-induced damage. We hypothesize that purinergic receptor signaling involving P2 nucleotide receptors may play a key role in mediating the bystander effect. We also discuss promising new therapeutic approaches to prevent salivary gland damage due to RT.


2011 ◽  
Vol 47 ◽  
pp. S119-S120
Author(s):  
L. Spiegelberg ◽  
U.M. Djasim ◽  
J.W. van Neck ◽  
E.B. Wolvius ◽  
K.G.H. van der Wal

2007 ◽  
Vol 28 (3) ◽  
pp. 147-151 ◽  
Author(s):  
Nobuaki HANAUE ◽  
Ienaka TAKEDA ◽  
Yasuhiro KIZU ◽  
Morio TONOGI ◽  
Gen-yuki YAMANE

Author(s):  
Lauren Gayle Meeks ◽  
Diogo De Oliveira Pessoa ◽  
Jessica Anne Martinez ◽  
Kirsten H. Limesand ◽  
Megha Padi

Radiation therapy for head and neck cancer causes damage to the surrounding salivary glands, resulting in salivary gland hypofunction and xerostomia. Current treatments do not provide lasting restoration of salivary gland function following radiation; therefore, a new mechanistic understanding of the radiation-induced damage response is necessary for identifying therapeutic targets. The purpose of the present study was to investigate the metabolic phenotype of radiation-induced damage in parotid salivary glands by integrating transcriptomic and metabolomic data. Integrated data were then analyzed to identify significant gene-metabolite interactions. Mice received a single 5 Gy dose of targeted head and neck radiation. Parotid tissue samples were collected 5 days following treatment for RNA sequencing and metabolomics analysis. Altered metabolites and transcripts significantly converged on a specific region in the metabolic reaction network. Both integrative pathway enrichment using rank-based statistics and network analysis highlighted significantly coordinated changes in glutathione metabolism, energy metabolism (TCA cycle and thermogenesis), peroxisomal lipid metabolism, and bile acid production with radiation. Integrated changes observed in energy metabolism suggest that radiation induces a mitochondrial dysfunction phenotype. These findings validated previous pathways involved in the radiation-damage response, such as altered energy metabolism, and identified robust signatures in salivary glands, such as reduced glutathione metabolism, that may be driving salivary gland dysfunction.


PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e51363 ◽  
Author(s):  
Katie L. Martin ◽  
Grace A. Hill ◽  
Rob R. Klein ◽  
Deborah G. Arnett ◽  
Randy Burd ◽  
...  

2015 ◽  
Vol 115 (2) ◽  
pp. 253-256 ◽  
Author(s):  
Graziella Chagas Jaguar ◽  
Eduardo Nóbrega Pereira Lima ◽  
Luiz Paulo Kowalski ◽  
Antônio Cássio Pellizzon ◽  
André Lopes Carvalho ◽  
...  

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