scholarly journals Oleanolic Acid Attenuates Morphine Withdrawal Symptoms in Rodents: Association with Regulation of Dopamine Function

2021 ◽  
Vol Volume 15 ◽  
pp. 3685-3696
Author(s):  
Zhiqi Shi ◽  
Shugang Pan ◽  
Luolin Wang ◽  
Sha Li
Keyword(s):  
Oleanolic Acid ◽  
Morphine Withdrawal ◽  
Withdrawal Symptoms

A new way to treat morphinism

1930 ◽  
Vol 26 (10) ◽  
pp. 1056-1056
Author(s):  
M. Sokel
Keyword(s):  
Morphine Withdrawal ◽  
Withdrawal Symptoms ◽  
New Treatment

Abstracts. Neuropathology and Psychiatry. Dr. M. Sokel describes (D. m. W. 1930, no. 42) a new treatment for morphinism. With the sudden withdrawal of morphine to avoid the phenomena of morphine withdrawal a. in the first 6-8 days he injected a large amount of insulin (up to 80 units of insulin "Leo" in 24 hours) without wine. Sahara. The amount of insulin depended on the severity of the withdrawal symptoms. A total of 15 patients were treated.

Mefloquine attenuated morphine withdrawal symptoms in rat

2016 ◽  
Vol 26 ◽  
pp. S688-S689
Author(s):  
S. Moradi ◽  
R. Motahari ◽  
K. Hassanzadeh
Keyword(s):  
Morphine Withdrawal ◽  
Withdrawal Symptoms

Evaluation on the Treatment of Morphine Addiction by Acupuncture Chinese Herbs and Opioid Peptides

1986 ◽  
Vol 14 (01n02) ◽  
pp. 46-50 ◽  
Author(s):  
Mabel M.P. Yang ◽  
John S. L. Kwok
Keyword(s):  
Opioid Peptides ◽  
Side Effect ◽  
Experimental Studies ◽  
Sedative Effect ◽  
Morphine Withdrawal ◽  
Chinese Herbs ◽  
Withdrawal Symptoms ◽  
Morphine Addiction ◽  
Supplementary Treatment

Experimental studies on the effects of acupuncture, combined Chinese herbs, and opioid peptides on morphine withdrawal symptoms were carried out in 119 addicted rats. Electroacupuncture was found to be the most effective method as it reduced the morphine withdrawal scores to -85%. The combined herbs, Qiang Huo, Gou Teng, Chuan Xion, Fu Zi and Yan Hu Suo suppressed the withdrawal scores of – 68%. The opioid peptides, endorphin, enkephalin, and dynorphin, produced marked sedative effect and alleviated the withdrawal symptoms, reducing the scores from -28% to -74%. It is suggested that acupuncture and herbs, being non-opiate and having less side effect, might be used as alternative supplementary treatment on morphine addiction.

scholarly journals STEP signaling pathway mediates psychomotor stimulation and morphine withdrawal symptoms, but not for reward, analgesia and tolerance

2016 ◽  
Vol 48 (2) ◽  
pp. e212-e212 ◽  
Author(s):  
Yoon-Jung Kim ◽  
Young Kang ◽  
Hye-Yeon Park ◽  
Jae-Ran Lee ◽  
Dae-Yeul Yu ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Morphine Withdrawal ◽  
Withdrawal Symptoms ◽  
Psychomotor Stimulation

scholarly journals Sirt3 mediated by lentiviral vector in the periaqueductal gray suppresses morphine withdrawal in rats: A preliminary study

2019 ◽  
Author(s):  
Shue Liu ◽  
Hyun Yi ◽  
Jun Gu ◽  
Daigo Ikegami ◽  
Kentaro Hayashi ◽  
...  
Keyword(s):  
Behavioral Response ◽  
Molecular Mechanisms ◽  
Lentiviral Vector ◽  
Morphine Withdrawal ◽  
Withdrawal Symptoms ◽  
Opioid Use ◽  
Chronic Morphine ◽  
Mitochondrial Energy Metabolism ◽  
Preliminary Study ◽  
Novel Therapeutic

AbstractOpioid use disorder (OUD) is a significant clinical and social problem, inducing dependence/addiction and over-dose death. Opioid dependence/withdrawal contributes to the addiction vulnerability. Limited understanding of the exact mechanisms of morphine withdrawal leads to failure to adequately manage opioid withdrawal symptoms. Determining new molecular mechanisms of morphine withdrawal (MW) may allow development of novel therapeutic strategies for treating this disorder. Chronic morphine with naloxone precipitation induces MW behavioral response. Sirt3 (one member of sirtuins family) as a mitochondrial fidelity, plays an important role in mitochondrial homeostasis through the direct regulation of mitochondrial energy metabolism, ATP synthesis, detoxification of mitochondrial ROS, etc. In the pilot study, we found that (1) cultured neurons infected with lentiviral vector expressing Sirt3 induced over-expression of Sirt3, (2) microinjection of LV-Sirt3 into the vlPAG increased Sirt3 protein expression in rats, (3) MW lowered the expression of Sirt3 in the vlPAG, and (4) microinjection of LV-Sirt3 into the vlPAG decreased the MW behavioral response. Current preliminary study demonstrates that complement of Sirt3 in the PAG suppressed MW, providing a novel therapeutic approach to morphine physical withdrawal symptoms. The exact up-and/or down-stream factors of Sirt3 in the model are under the investigation.

Sign in / Sign up

Export Citation Format

Share Document