scholarly journals Patient-reported outcomes after discontinuation of long-term topical corticosteroid treatment for atopic dermatitis: a targeted cross-sectional survey

2015 ◽  
pp. 57 ◽  
Author(s):  
Naoko Takahashi-Ando ◽  
Mark Jones ◽  
Shigeki Fujisawa ◽  
Rokuro Hama
2020 ◽  
Vol 20 (5) ◽  
pp. e651-e662 ◽  
Author(s):  
Li Juanjuan ◽  
Cesar Augusto Santa-Maria ◽  
Feng Hongfang ◽  
Wang Lingcheng ◽  
Zhang Pengcheng ◽  
...  

2014 ◽  
Vol 20 (8) ◽  
pp. 1102-1111 ◽  
Author(s):  
Angela Senders ◽  
Douglas Hanes ◽  
Dennis Bourdette ◽  
Ruth Whitham ◽  
Lynne Shinto

Background: Patient-reported outcomes are important for clinical research and care, yet administering and scoring the questionnaires requires considerable effort and time. The Patient Reported Outcomes Measurement Information System (PROMIS) could considerably reduce administrative obstacles and lessen survey burden for participants. Objective: Assess the feasibility and validity of PROMIS, compared to commonly-used legacy measures for multiple sclerosis (MS). Methods: In this cross-sectional survey, 133 participants with confirmed MS completed legacy surveys and PROMIS Computerized Adaptive Tests (CATs) for depression, anxiety, pain, fatigue and physical function. We conducted a multi-trait, multi-method analysis and verified results with confirmatory factor analysis. Results: The correlations between PROMIS and the corresponding legacy measures were large (0.67 to 0.87). The multi-trait, multi-method criteria were generally well met, providing good evidence of the validity of PROMIS measures. PROMIS surveys asked fewer questions and required substantially less time to complete than the legacy scales. Conclusions: Our results provide evidence of the construct validity of PROMIS for use with MS patients. Several aspects of the PROMIS CATs made them an important resource, including: (a) less time was required to complete them; (b) missing data was reduced; and (c) the automatic scoring referenced the general population. Our findings support the use of PROMIS in MS research and may have broader implications for clinical care, as well.


BMJ Open ◽  
2013 ◽  
Vol 3 (4) ◽  
pp. e002317 ◽  
Author(s):  
Adam W Glaser ◽  
Lorna K Fraser ◽  
Jessica Corner ◽  
Richard Feltbower ◽  
Eva J A Morris ◽  
...  

BMJ Open ◽  
2014 ◽  
Vol 4 (5) ◽  
pp. e004709 ◽  
Author(s):  
Selina Kikkenborg Berg ◽  
Jette Svanholm ◽  
Astrid Lauberg ◽  
Britt Borregaard ◽  
Margrethe Herning ◽  
...  

2020 ◽  
pp. 194173812094632
Author(s):  
Joshua J. Van Wyngaarden ◽  
Cale Jacobs ◽  
Katherine Thompson ◽  
Molly Eads ◽  
Darren Johnson ◽  
...  

Background: Many patients live with long-term deficits in knee function after an anterior cruciate ligament reconstruction (ACLR). However, research is inconclusive as to which physical performance measure is most strongly related to long-term patient-reported outcomes after ACLR. Hypothesis: Quadriceps strength would be most strongly associated with patient-reported long-term outcomes after ACLR. Study Design: Cross-sectional study. Level of Evidence: Level 3. Methods: A total of 40 patients (29 female) consented and participated an average of 10.9 years post-ACLR (range, 5-20 years). Patients completed the Lower Extremity Functional Scale (LEFS), the International Knee Documentation Committee (IKDC) Scale, Knee injury and Osteoarthritis Outcome Score Quality of Life (KOOS QoL) and Sport (KOOS Sport) subscales, and the Tampa Scale of Kinesiophobia (TSK-17). Each patient subsequently performed maximal isometric quadriceps contraction, a 60-second single-leg step-down test, and the single-leg single hop and triple hop for distance tests. Multivariate linear and logistic regression models determined how performance testing was associated with each patient-reported outcome when controlling for time since surgery, age, and TSK-17. Results: When controlling for time since surgery, age at the time of consent, and TSK-17 score, maximal isometric quadriceps strength normalized to body weight was the sole physical performance measure associated with IKDC ( P < 0.001), KOOS Sport ( P = 0.006), KOOS QoL ( P = 0.001), and LEFS scores ( P < 0.001). Single-leg step-down, single hop, and triple hop did not enter any of the linear regression models ( P > 0.20). Additionally, TSK-17 was associated with all patient-reported outcomes ( P ≤ 0.01) while time since surgery was not associated with any outcomes ( P > 0.05). Conclusion: Isometric quadriceps strength and kinesiophobia are significantly associated with long-term patient-reported outcomes after ACLR. Clinical Relevance: These results suggest that training to improve quadriceps strength and addressing kinesiophobia in the late stages of recovery from ACLR may improve long-term self-reported function.


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