scholarly journals Fecal Microbiota Transplantation as an Effective Treatment for Carbapenem-Resistant Klebsiella pneumoniae Infection in a Renal Transplant Patient

2021 ◽  
Vol Volume 14 ◽  
pp. 1805-1811
Author(s):  
Junpeng Wang ◽  
Xin Li ◽  
Xiaoqiang Wu ◽  
Zhiwei Wang ◽  
Xuan Wu ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Klebsiella Pneumoniae ◽  
Effective Treatment ◽  
Renal Transplant Patient ◽  
Transplant Patient ◽  
Fecal Microbiota Transplantation ◽  
Fecal Microbiota ◽  
Carbapenem Resistant

scholarly journals Fecal microbiota transplantation as an effective treatment for carbapenem-resistant Klebsiella pneumoniae infection in a renal transplant patient

2020 ◽  
Author(s):  
Junpeng Wang ◽  
Xin Li ◽  
Xiaoqiang Wu ◽  
Zhiwei Wang ◽  
Xuan Wu ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Renal Transplant ◽  
Klebsiella Pneumoniae ◽  
Renal Transplant Patient ◽  
Transplant Patient ◽  
Fecal Microbiota Transplantation ◽  
Fecal Microbiota ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Carbapenem Resistant

Abstract Background: In renal transplant recipients, carbapenem-resistant Klebsiella pneumoniae (CRKP) infection is common, and usually associated with severe clinical outcomes due to a lack of effective therapeutics.Case presentation: A 37-year-old female had a CRKP infection one month after the kidney transplantation. Since the effect of the antibiotic therapy was limited, fecal microbiota transplantation (FMT) was performed. FMT resulted in increased richness and diversity of gut microbiota and reduced relative abundance of Klebsiella. After FMT, the infection of the patient caused by CRKP was well controlled without inducing adverse effects.Conclusion: This study demonstrated the therapeutic effect of FMT on CRKP infection, and may shine some light on the treatment of the infections caused by CRKP for the patients after transplantation.

scholarly journals TAM mediates adaptation of carbapenem-resistant Klebsiella pneumoniae to antimicrobial stress during host colonization and infection

2021 ◽  
Vol 17 (2) ◽  
pp. e1009309
Author(s):  
Hea-Jin Jung ◽  
Matthew T. Sorbara ◽  
Eric G. Pamer
Keyword(s):  
Molecular Weight ◽  
Klebsiella Pneumoniae ◽  
Antimicrobial Agents ◽  
Fecal Microbiota Transplantation ◽  
Systemic Infection ◽  
Clinical Problem ◽  
Fecal Microbiota ◽  
Carbapenem Resistant ◽  
Response To Stress ◽  
Strain Stress

Gram-negative pathogens, such as Klebsiella pneumoniae, remodel their outer membrane (OM) in response to stress to maintain its integrity as an effective barrier and thus to promote their survival in the host. The emergence of carbapenem-resistant K. pneumoniae (CR-Kp) strains that are resistant to virtually all antibiotics is an increasing clinical problem and OM impermeability has limited development of antimicrobial agents because higher molecular weight antibiotics cannot access sites of activity. Here, we demonstrate that TAM (translocation and assembly module) deletion increases CR-Kp OM permeability under stress conditions and enhances sensitivity to high-molecular weight antimicrobials. SILAC-based proteomic analyses revealed mis-localization of membrane proteins in the TAM deficient strain. Stress-induced sensitization enhances clearance of TAM-deficient CR-Kp from the gut lumen following fecal microbiota transplantation and from infection sites following pulmonary or systemic infection. Our study suggests that TAM, as a regulator of OM permeability, represents a potential target for development of agents that enhance the effectiveness of existing antibiotics.

Topical imiquimod cream 5% for resistant perianal warts in a renal transplant patient

2002 ◽  
Vol 13 (7) ◽  
pp. 501-503 ◽  
Author(s):  
S L Gayed
Keyword(s):  
Renal Transplant ◽  
Effective Treatment ◽  
Renal Transplant Patient ◽  
Transplant Patient ◽  
Genital Warts ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Imiquimod Cream ◽  
Patient Subgroup ◽  
Genitourinary Medicine

Renal transplant recipients represent a patient subgroup for whom the effective treatment of genital warts poses a significant problem in genitourinary medicine. This case demonstrates the safe and effective treatment of resistant perianal warts in a male renal transplant recipient using imiquimod.

Topical imiquimod cream 5% for resistant perianal warts in a renal transplant patient

2002 ◽  
Vol 13 (5) ◽  
pp. 349-351 ◽  
Author(s):  
S L Gayed
Keyword(s):  
Renal Transplant ◽  
Effective Treatment ◽  
Renal Transplant Patient ◽  
Transplant Patient ◽  
Genital Warts ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Imiquimod Cream ◽  
Patient Subgroup ◽  
Genitourinary Medicine

Renal transplant recipients represent a patient subgroup for whom the effective treatment of genital warts poses a significant problem in genitourinary medicine. This case demonstrates the safe and effective treatment of resistant perianal warts in a male renal transplant recipient using imiquimod.

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