scholarly journals MAGGIC Risk Model Predicts Adverse Events and Left Ventricular Remodeling in Non-Ischemic Dilated Cardiomyopathy

2020 ◽  
Vol Volume 13 ◽  
pp. 1477-1486
Author(s):  
Yang Dong ◽  
Dongfei Wang ◽  
Jialan Lv ◽  
Zhicheng Pan ◽  
Rui Xu ◽  
...  
Keyword(s):  
Adverse Events ◽  
Dilated Cardiomyopathy ◽  
Ventricular Remodeling ◽  
Risk Model ◽  
Left Ventricular Remodeling ◽  
Left Ventricular ◽  
Non Ischemic Dilated Cardiomyopathy

scholarly journals Cardiac Sodium Channel Dysfunction and Dilated Cardiomyopathy: A Contemporary Reappraisal of Pathophysiological Concepts

2019 ◽  
Vol 8 (7) ◽  
pp. 1029 ◽  
Author(s):  
Asatryan
Keyword(s):  
Dilated Cardiomyopathy ◽  
Sodium Channel ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Left Ventricular ◽  
Conduction Disturbances ◽  
Pathogenic Variants ◽  
Cardiac Sodium Channel ◽  
Precision Therapy ◽  
Bona Fide

A key emerging theme in translational cardiovascular medicine is the need to identify specific causes of arrhythmias and heart failure, defined by phenotype and/or genotype that will respond to a particular intervention. Unlike other genes implicated in hereditary arrhythmias and cardiomyopathies, pathogenic/likely pathogenic variants in the cardiac sodium channel alpha subunit gene (SCN5A) produce a remarkably diverse set of electrical and structural phenotypes, one of them being dilated cardiomyopathy. There has been debate about whether left ventricular remodeling is a bona fide phenotypic feature of cardiac sodium channel dysfunction, or a consequence of tachyarrhythmias or conduction disturbances. In light of recent findings, a critical digest of the available experimental and medical literature is necessary. This paper provides a critical appraisal of the evidence linking a dysfunctional cardiac sodium channel to ventricular dysfunction, and discusses the potential mechanisms involved in shaping this phenotype along with implications for precision therapy.

Tenascin-C as Predictor of Left Ventricular Remodeling and Mortality in Patients With Dilated Cardiomyopathy

2013 ◽  
Vol 61 (4) ◽  
pp. 728-732 ◽  
Author(s):  
Bahadir Sarli ◽  
Ramazan Topsakal ◽  
Esma G. Kaya ◽  
Mahmut Akpek ◽  
Yat Yin Lam ◽  
...  
Keyword(s):  
Dilated Cardiomyopathy ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Left Ventricular ◽  
Tenascin C

scholarly journals Tenascin-C as Predictor of Left Ventricular Remodeling and Mortality in Patients with Dilated Cardiomyopathy

2013 ◽  
Vol 62 (18) ◽  
pp. C104-C105
Author(s):  
Bahadır Şarlı ◽  
Topsakal Ramazan ◽  
Esma G Kaya ◽  
Mahmut Akpek ◽  
Yat Yin Lam ◽  
...  
Keyword(s):  
Dilated Cardiomyopathy ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Left Ventricular ◽  
Tenascin C
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