Parents’ hyper-pitch and vowel category compactness in infant-directed speech are associated with 18-month-old toddlers’ expressive vocabulary

The present study examines the acoustic properties of infant-directed speech (IDS) as compared to adult-directed speech (ADS) in Norwegian parents of 18-month-old toddlers, and whether these properties relate to toddlers’ expressive vocabulary size. Twenty-one parent- toddler dyads from Tromsø, Northern Norway participated in the study. Parents (16 mothers, 5 fathers), speaking a Northern Norwegian dialect, were recorded in the lab reading a storybook to their toddler (IDS register), and to an experimenter (ADS register). The storybook was designed for the purpose of the study, ensuring identical linguistic contexts across speakers and registers, and multiple representations of each of the nine Norwegian long vowels. We examined both traditionally reported measures of IDS: pitch, pitch range, vowel duration and vowel space expansion, but also novel measures: vowel category compactness and vowel category distinctiveness. Our results showed that Norwegian IDS, as compared to ADS, had similar characteristics as in other languages: higher pitch, wider pitch range, longer vowel duration, and expanded vowel space area; in addition, it had less compact vowel categories. Further, parents’ hyper-pitch, that is, the within-parent increase in pitch in IDS as compared to ADS, and vowel category compactness in IDS itself, were positively related to toddlers' vocabulary. Our results point towards potentially facilitating roles of parents’ increase in pitch when talking to their toddler and of consistency in vowel production in early word learning.

Electrocatalytic Oxidative Hydrofunctionalization Reactions of Alkenes via Co(II/III/IV) Cycle

Here we disclose a general and versatile Co(II/III/IV) electrocatalytic platform for alkene functionalization. Driven by electricity, a set of the oxidative hydrofunctionalization reactions initiated by hydrogen atom transfer were demonstrated without the need for stochiometric chemical oxidants. The scope of the reactions encompasses hydroalkoxylation, hydroacyloxylation, hydroarylation, semi-pinacol rearrangement, and deallylation. Mechanistic studies and stereochemical evidence support an ECEC process involving an electrochemically-generated organocobalt(IV) intermediate. This work presents an example of reactivity space expansion in electrocatalysis of VB12-systems by going beyond the common oxidation states of Co(I/II/III).

Clinical and Microbiological Factors Associated With Abscess Formation in Adult Acute Epiglottitis

Objectives: To evaluate clinical and microbiological findings that are correlated with abscess formation in adult acute epiglottitis (AE). Methods: We reviewed 140 cases of adult AE. Demographic, clinical, imaging, and microbiological findings are analyzed for all patients with AE in comparison to those with epiglottic abscess (EA). Results: A total of 113 patients presented with AE and 27 presented or progressed to EA (19.3%). Age, sex, seasonality, smoking, body mass index (BMI), and comorbidities were statistically insignificant between the 2 groups. Muffled voice ( P < .013), respiratory distress ( P < .001), and pre-existence of epiglottic cyst ( P < .001) are symptoms and signs connected with abscess formation. A total of 120 patients were treated conservatively. Surgical treatment was performed on 20 patients with EA. About 72 out of 80 cultures revealed monomicrobial infection. Mixed flora was isolated in 8 patients with EA. Streptococcus was isolated in 51 out of 80 positive cultures (64%). Haemophilus Influenza ( Hib) was not isolated in any sample. EA and mixed flora relates to a higher rate of airway intervention ( P < .001). Conclusion: A high level of suspicion for abscess formation is required if clinical examination reveals dyspnea, muffled voice, or an epiglottic cyst in adult with AE. The existence of EA doubles the duration of hospitalization. EA is typically found on the lingual surface of the epiglottis. Supraglottic or deep neck space expansion should be treated surgically. EA is associated with a mixed flora and a higher rate of airway obstruction. Streptococcus is discovered to be the most common pathogen.

Chimpanzee vowel-like sounds and voice quality suggest formant space expansion through the hominoid lineage

The origins of human speech are obscure; it is still unclear what aspects are unique to our species or shared with our evolutionary cousins, in part due to a lack of a common framework for comparison. We asked what chimpanzee and human vocal production acoustics have in common. We examined visible supra-laryngeal articulators of four major chimpanzee vocalizations (hoos, grunts, barks, screams) and their associated acoustic structures, using techniques from human phonetic and animal communication analysis. Data were collected from wild adult chimpanzees, Taï National Park, Ivory Coast. Both discriminant and principal component classification procedures revealed classification of call types. Discriminating acoustic features include voice quality and formant structure, mirroring phonetic features in human speech. Chimpanzee lip and jaw articulation variables also offered similar discrimination of call types. Formant maps distinguished call types with different vowel-like sounds. Comparing our results with published primate data, humans show less F1–F2 correlation and further expansion of the vowel space, particularly for [i] sounds. Unlike recent studies suggesting monkeys achieve human vowel space, we conclude from our results that supra-laryngeal articulatory capacities show moderate evolutionary change, with vowel space expansion continuing through hominoid evolution. Studies on more primate species will be required to substantiate this. This article is part of the theme issue ‘Voice modulation: from origin and mechanism to social impact (Part II)’.

Semi-automated workflow for molecular pair analysis and QSAR-assisted transformation space expansion

In the process of drug discovery, the optimization of lead compounds has always been a challenge faced by pharmaceutical chemists. Matched molecular pair analysis (MMPA), a promising tool to efficiently extract and summarize the relationship between structural transformation and property change, is suitable for local structural optimization tasks. Especially, the integration of MMPA with QSAR modeling can further strengthen the utility of MMPA in molecular optimization navigation. In this study, a new semi-automated procedure based on KNIME was developed to support MMPA on both large- and small-scale datasets, including molecular preparation, QSAR model construction, applicability domain evaluation, and MMP calculation and application. Two examples covering regression and classification tasks were provided to gain a better understanding of the importance of MMPA, which has also shown the reliability and utility of this MMPA-by-QSAR pipeline.

On cosmological expansion and local physics

We find an exact convergence in the local dynamics described by two supposedly antagonistic approaches applied at the local, solar system scale: one starting from an expanding universe perspective such as FLRW, the other based on a local model ignoring any notion of expansion, such as static Schwarzschild dS. Both models are in complete agreement when the local effects of the expansion are circumscribed to the presence of the cosmological constant. We elaborate on the relevant role of static backgrounds like the Schwarzschild-dS metric in standard form as the most proper coordinatizations to describe physics at the local scale. We also elaborate on the popular expanding 3-space picture—to be distinguished from that of the expanding universe—and point out the confusion of scales which is typically associated with it. Finally, making use of an old and too often forgotten relativistic kinematical invariant, we address some remaining misunderstandings on space expansion, cosmological and gravitational redshifts. As a byproduct we propose a unique and unambiguous prescription to match the local and cosmological expression of a specific observable.

The Evolution of the Urban Residential Space Structure and Driving Forces in the Megacity—A Case Study of Shenyang City

For megacities, they are in a period of transformation from extensive development to smart growth. Recognizing new characteristics and new changes of the residential space in megacities under the backdrop of new development has great practical significance for realizing the sustainable development of the city. As the only megacity in Northeast China, Shenyang was selected to be the research object, with 1989–2018 as the research period. The research comprehensively used multiple spatial representation methods and statistical methods to study the residential space pattern and driving factors in Shenyang City. The results showed that: (1) Residential space expansion can be divided into four stages: slow development, rapid expansion, speedy expansion, and stable extension. (2) The residential space structure presented a spatial evolution characteristic of overall expansion, forming multiple secondary core density centers. The east-west direction had a larger extension range than the northeast-southwest direction. There was an axisymmetric zonal distribution on both sides of the Hun River. (3) The agglomeration of different residential forms was obvious, and the spatial heterogeneity was increasingly stronger. (4) Urban planning measures and economic strength were the main driving forces of residential space expansion.