scholarly journals A SIMPLE ONE-POT SYNTHESIS OF PYRIMIDO[4,5-C]PYRIDAZINES AND IN SILICO STUDIES OF HUMAN AKT1 INHIBITORS

2021 ◽  
Vol 9 (10) ◽  
pp. 136-142
Author(s):  
Laldingluaia Khiangte ◽  
Keyword(s):  
Binding Energy ◽  
Multicomponent Reaction ◽  
In Silico ◽  
Synthetic Method ◽  
Autodock Vina ◽  
One Pot ◽  
One Pot Synthesis ◽  
In Silico Studies ◽  
Inhibitory Activities

A simple one-pot and efficient synthetic method for the synthesis of pyrimido[4,5-c]pyridazine by a multicomponent reaction. The synthesis compounds are study for their inhibitory activities towards AKT1 pathways by using in silico method. It was found that all compounds have binding energy lower than -7.9 kcal/mol and compound 3a is the most active with binding energy -9.65 kcal/mol, which have been performed using autodock vina.

2-Oxo-1,2,3,4-tetrahydropyrimidines Ethyl Esters as Potent β- Glucuronidase Inhibitors: One-pot Synthesis, In vitro and In silico Studies

2018 ◽  
Vol 14 (8) ◽  
pp. 818-830 ◽  
Author(s):  
Sarosh Iqbal ◽  
Nimra N. Shaikh ◽  
Khalid M. Khan ◽  
Sehrish Naz ◽  
Zaheer Ul-Haq ◽  
...  
Keyword(s):  
In Silico ◽  
Ethyl Esters ◽  
One Pot ◽  
One Pot Synthesis ◽  
In Silico Studies

One pot synthesis, in silico study and evaluation of some novel flavonoids as potent topoisomerase II inhibitors

2021 ◽  
Vol 40 ◽  
pp. 127916
Author(s):  
Aniket P. Sarkate ◽  
Vidya S. Dofe ◽  
Shailee V. Tiwari ◽  
Deepak K. Lokwani ◽  
Kshipra S. Karnik ◽  
...  
Keyword(s):  
In Silico ◽  
Topoisomerase Ii ◽  
One Pot ◽  
Topoisomerase Ii Inhibitors ◽  
One Pot Synthesis ◽  
In Silico Study

A heavy metal- and oxidant-free, one-pot synthesis of pyridines and fused pyridines based on a Lewis acid-catalyzed multicomponent reaction

2014 ◽  
Vol 50 (82) ◽  
pp. 12270-12272 ◽  
Author(s):  
V. P. Alex Raja ◽  
Giammarco Tenti ◽  
Subbu Perumal ◽  
J. Carlos Menéndez
Keyword(s):  
Heavy Metal ◽  
Lewis Acid ◽  
Multicomponent Reaction ◽  
One Pot ◽  
One Pot Synthesis ◽  
Acid Catalyzed

Pyridines and fused pyridines are accessible by a combination of a Lewis acid-catalyzed multicomponent reaction and aromatization involving loss of a 2-furylmethyl chain.

Combining click-multicomponent reaction: one-pot synthesis of triazolyl methoxy-phenyl indazolo[2,1-b]phthalazine-trione derivatives

2011 ◽  
Vol 16 (2) ◽  
pp. 231-240 ◽  
Author(s):  
Peyman Salehi ◽  
David I. MaGee ◽  
Minoo Dabiri ◽  
Laleh Torkian ◽  
Jordan Donahue
Keyword(s):  
Multicomponent Reaction ◽  
One Pot ◽  
One Pot Synthesis

scholarly journals A rare γ-pyranopyrazole skeleton: design, one-pot synthesis and computational study

2016 ◽  
Vol 14 (31) ◽  
pp. 7490-7494 ◽  
Author(s):  
Muhammed Üçüncü ◽  
Ceren Cantürk ◽  
Erman Karakuş ◽  
Hüseyin Zeybek ◽  
Uğur Bozkaya ◽  
...  
Keyword(s):  
Computational Study ◽  
Synthetic Method ◽  
One Pot ◽  
One Pot Synthesis

A base mediated one-pot, two-step synthetic method for constructing γ-pyranopyrazoles.

A facile one-pot synthesis of deep blue luminescent lead bromide perovskite microdisks

2015 ◽  
Vol 51 (91) ◽  
pp. 16385-16388 ◽  
Author(s):  
Zhao Yuan ◽  
Yu Shu ◽  
Yu Tian ◽  
Yan Xin ◽  
Biwu Ma
Keyword(s):  
Thin Films ◽  
Room Temperature ◽  
Quantum Yields ◽  
Synthetic Method ◽  
Lateral Size ◽  
One Pot ◽  
One Pot Synthesis ◽  
Deep Blue ◽  
Lead Bromide

We report a facile one-pot synthetic method to prepare highly luminescent layered lead(ii) bromide perovskite microdisks with the lateral size of a few micrometers and thickness of 100–150 nm, featuring narrow deep blue emissions with quantum yields of up to 53% in toluene solutions and thin films at room temperature.

scholarly journals One-pot synthesis, anti-tumor evaluation and structure–activity relationships of novel 25-OCH3-PPD derivatives

MedChemComm ◽  
2017 ◽  
Vol 8 (9) ◽  
pp. 1845-1849 ◽  
Author(s):  
Fan-Zhi Qu ◽  
Chen Zhao ◽  
Jia-Qing Cao ◽  
Yan Zhang ◽  
Yu-Qing Zhao
Keyword(s):  
Panax Ginseng ◽  
Synthetic Method ◽  
Lead Compound ◽  
One Pot ◽  
Structure Activity Relationships ◽  
One Pot Synthesis ◽  
Structure Activity

Based on the fact that 25-OCH3-PPD, a natural ginsengenin isolated from the leaves of Panax ginseng, is a promising lead compound, novel 25-OCH3-PPD derivatives were synthesized to find more potent anti-tumor agents by a simple and facile synthetic method.

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