Effect of mineral deficiencies on the red blood cell parameters in cattle

Mineral deficiencies are a common problem in dairy herds around the world. Currently, they most often occur in a subclinical form or with atypical symptoms, which makes their diagnosis difficult. New methods and possibilities of identifying mineral deficiencies are being sought. Hematological changes may occur in the early stages of the development of deficiency diseases, and their detection may be helpful in the early diagnosis of diseases. The aim of the article is to present the most important information on disorders in the red blood cell system in the course of mineral deficiencies in dairy cattle. Hematological tests should become one of the most important elements facilitating the determination of the health condition of cows and enabling the correct diagnosis and therapy of cattle diseases. Copper, iron, magnesium and phosphorus deficiencies cause changes in hematological parameters. In iron and copper deficiency, there are microcytic, hypochromatic or normocytic, normochromic anemia. On the other hand, in the deficiency of magnesium and phosphorus, there is normocytic, normochromic anemia.

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Thyroid Dysfunction and its Effect on Red Blood Cell Parameters

Journal of Nobel Medical College ◽

10.3126/jonmc.v10i2.41777 ◽

2021 ◽

Vol 10 (2) ◽

pp. 54-57

Author(s):

Samir Singh

Keyword(s):

Blood Cell ◽

Red Blood Cell ◽

Metabolic Regulation ◽

Thyroid Dysfunction ◽

Hematological Parameters ◽

Chi Square ◽

Cell Parameters ◽

Significant Difference ◽

The Mean ◽

The Difference

Background: Thyroid hormones are necessary for the growth and development, cellular differentiation, physiological function and metabolic regulation of almost all tissues in our body. Thyroid disorders are accompanied by alteration in hematological profile. This study aims to evaluate the effect of thyroid dysfunction on red blood cell parameters. Materials and Methods: This case-control observational study was conducted in the Department of Clinical Biochemistry, KIST Medical College and Teaching Hospital (KISTMCTH), Lalitpur, Nepal from January 2021 to June 2021.Total number of recruited subjects was 248, out of which 67 were labeled as hypothyroid, 7 were hyperthyroid and 174 were euthyroid as control. Subjects for all three groups were between 16-93 years old. Thyroid hormone profile of patients was determined by Siemens ADVIA Centaur CP immunoassay analyzer and hematological parameters by automated hematology analyzer Sysmex XN-550. Results were analyzed by SPSS 21 software and a chi-square test was applied to see significant differences among the groups. Results: The mean age of all study participants was 42.08±17.27 years and female constituted 74.6% of total subjects. Analysis of the data obtained a statistically significant difference in the mean hemoglobin (p<0.001) between hypothyroid and euthyroid groups. The difference was not significant for hemoglobin (p=0.252) among hyperthyroid and euthyroid groups. There was no statistical significant difference between thyroid cases and control for MCV, MCH and MCHC. Conclusion: The current study concluded that thyroid dysfunction have a significant effect on red blood cell parameters. Hematological parameters should be evaluated in patient with thyroid dysfunction.

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Reference intervals for hematology test parameters from apparently healthy individuals in southwest Ethiopia

SAGE Open Medicine ◽

10.1177/2050312118807626 ◽

2018 ◽

Vol 6 ◽

pp. 205031211880762 ◽

Cited By ~ 6

Author(s):

Lealem Gedefaw Bimerew ◽

Tesfaye Demie ◽

Kaleab Eskinder ◽

Aklilu Getachew ◽

Shiferaw Bekele ◽

...

Keyword(s):

Platelet Count ◽

Blood Cell ◽

White Blood Cell ◽

Red Blood Cell ◽

Hematological Parameters ◽

Age Groups ◽

Reference Interval ◽

Reference Intervals ◽

Southwest Ethiopia ◽

Apparently Healthy

Background: Clinical laboratory reference intervals are an important tool to identify abnormal laboratory test results. The generating of hematological parameters reference intervals for local population is very crucial to improve quality of health care, which otherwise may lead to unnecessary expenditure or denying care for the needy. There are no well-established reference intervals for hematological parameters in southwest Ethiopia. Objective: To generate hematological parameters reference intervals for apparently healthy individuals in southwest Ethiopia. Methods: A community-based cross-sectional study was conducted involving 883 individuals from March to May 2017. Four milliliter of blood sample was collected and transported to Jimma University Medical Center Laboratory for hematological analysis and screening tests. A hematological parameters were measured by Sysmex XS-500i hematology analyzer (Sysmex Corporation Kobe, Japan). The data were analyzed by SPSS version 20 statistical software. The non-parametric independent Kruskal–Wallis test and Wilcoxon rank-sum test (Mann–Whitney U test) were used to compare the parameters between age groups and genders. The 97.5 percentile and 2.5 percentile were the upper and lower reference limit for the population. Results: The reference interval of red blood cell, white blood cell, and platelet count in children were 4.99 × 1012/L (4.26–5.99 × 1012/L), 7.04 × 109/L (4.00–11.67 × 109/L), and 324.00 × 109/L (188.00–463.50 × 109/L), respectively. The reference interval of red blood cell, white blood cell, and platelet count in adults was 5.19 × 1012/L (4.08–6.33 × 1012/L), 6.35 × 109/L (3.28–11.22 × 109/L), and 282.00 × 109/L (172.50–415.25 × 109/L), respectively. The reference interval of red blood cell, white blood cell, and platelet count in geriatrics were 5.02 × 1012/L (4.21–5.87 × 1012/L), 6.21 × 109/L (3.33–10.03 × 109/L), and 265.50 × 109/L (165.53–418.80 × 109/L), respectively. Most of the hematological parameters showed significant differences across all age groups. Conclusion: Most of the hematological parameters in this study showed differences from similar studies done in the country. This study provided population-specific hematological reference interval for southwest Ethiopians. Reference intervals should also be established in the other regions of the country.

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The association of red blood cell parameters with mortality in a population of hemodialysis patients

Dialysis & Transplantation ◽

10.1002/dat.20508 ◽

2011 ◽

Vol 40 (2) ◽

pp. 72-77 ◽

Cited By ~ 2

Author(s):

Brian E. Michel

Keyword(s):

Blood Cell ◽

Red Blood Cell ◽

Hemodialysis Patients ◽

Cell Parameters

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The effect of thyroid hormone deficiency on erythropoiesis in dogs

Acta Veterinaria Brno ◽

10.2754/avb201988030257 ◽

2019 ◽

Vol 88 (3) ◽

pp. 257-264 ◽

Cited By ~ 1

Author(s):

Olga Aniołek

Keyword(s):

Thyroid Hormone ◽

Blood Cell ◽

Red Blood Cell ◽

Clinical Symptoms ◽

Cell System ◽

Hormone Deficiency ◽

Control Group ◽

Average Mass ◽

Packed Red Blood Cells ◽

Experimental Group

This research aimed to evaluate the effect of thyroid hormone deficiency on the erythrocytic system in dogs. Dogs with clinical symptoms of hypothyreosis such as obesity, hyperpigmentation, and lethargy were selected. The dogs demonstrating breed predisposition to hypothyreosis were incorporated in the analysis: Dachshunds, Retrievers, and mixed-breed dogs. A detailed history was taken and clinical, hormonal, biochemical and haematological blood tests were performed. Peripheral blood samples were taken from 53 dogs. Finally, the dogs with the initial T4 (thyroxine) concentration < 1.3 µg/dl and animals demonstrating clinical improvement after a 2-month therapy with levothyroxine at a dose of 10 µg/kg administeredper ostwo times a day were qualified. The animals between 10 months to 13 years of age were divided into two groups: clinically healthy (control group, n = 35) and dogs presenting clinical symptoms of hypothyreosis (experimental group, n = 18). In this research, the broadly described normocytic normochromic non-regenerative anaemia was not diagnosed in dogs with hypothyreosis. However, a positive correlation between T4 and red blood cell indices such as the average mass of haemoglobin per red blood cell, concentration of haemoglobin in a given volume of packed red blood cells as well as a negative correlation with haematocrit value was discovered in the experimental group after the 2-month therapy with levothyroxine. These results point to the influence of thyroid hormones on erythropoiesis. This observation is partially consistent with other studies, which noted the casual link between the changes in red blood cell system and the function of thyroid in dogs and humans.

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