scholarly journals Use of Sysmex XN‐10 red blood cell parameters for screening of hereditary red blood cell diseases and iron deficiency anaemia

2020 ◽  
Vol 42 (6) ◽  
pp. 697-704
Author(s):  
Vanessa Nivaggioni ◽  
Lakhdar Bouriche ◽  
Sylvie Coito ◽  
Anne‐Sophie Le Floch ◽  
Manal Ibrahim‐Kosta ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Iron Deficiency Anaemia ◽  
Deficiency Anaemia ◽  
Cell Parameters

scholarly journals Iron-deficiency anaemia enhances red blood cell oxidative stress

2008 ◽  
Vol 42 (9) ◽  
pp. 824-829 ◽  
Author(s):  
Enika Nagababu ◽  
Seema Gulyani ◽  
Christopher J. Earley ◽  
Roy G. Cutler ◽  
Mark P. Mattson ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Iron Deficiency ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Iron Deficiency Anaemia ◽  
Deficiency Anaemia

scholarly journals Effect of Squid (Sepiotheutis lessoniana) Ink on Hematological Profile of Rats Rattus norvegicus

2020 ◽  
pp. 39-49
Author(s):  
Delianis Pringgenies ◽  
Meida M. M. Pertiwi ◽  
Ali Ridlo
Keyword(s):  
Iron Deficiency ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Iron Content ◽  
Rattus Norvegicus ◽  
Iron Deficiency Anaemia ◽  
Positive Control ◽  
Negative Control ◽  
Deficiency Anaemia ◽  
Low Dosage

Iron deficiency anaemia includes the highest incidence of nutritional deficiency diseases in the world. Red cell indices on full blood counts is regularly used to diagnose early anaemia. Currently strategies medicines of iron deficiency anaemia are belonged to preventif medicine as well as fortification of food and iron supplementation directly to the body. Recent studies show the effectiveness of treatment of iron deficiency anaemia in rats with squid ink. This study aim is to analyse the iron content of squid ink (Sepioteuthis lessoniana) and squid ink effects on haematological profile of male Wistar rat Rattus norvegicus. The measured iron content of squid ink (Sepioteuthis lessoniana) is 2,14 ± 0,46 mg/g. Rats were used in this study, are induced NaNO2 (50 mg/kgbw (1 ml dosing volume)) at first, then divided into 4 groups experiment for 14 days experimental. The 1st group is negative control (without any treatment), 2nd group is positive control (with Sangobion®), 3rd group is given a low dosage of squid ink (10 mg/kgbw/day) and the last 4thgroup is given a high dosage of squid ink (100 mg/kgbw/day). Based on the result, there was an effect of given squid ink to the haemoglobin, hematocrit, mean corpuscular volume, mean corpuscular haemoglobin concentration, mean haemoglobin content, red blood cell distribution width and red blood cell count of rats that showed by increasing numbers to the end of the experiment compared to the negative control (1st group). The most significant effect is in haemoglobin, especially Hb of rats which appeared on the low dosage of squid ink group and positive control group to the negatif group (p<0,05).

scholarly journals Efficacy and cost effectiveness of intravenous ferric carboxymaltose versus iron sucrose in adult patients with iron deficiency anaemia

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0255104
Author(s):  
Ahmad Basha ◽  
Mohamed Izham Mohamed Ibrahim ◽  
Anas Hamad ◽  
Prem Chandra ◽  
Nabil E. Omar ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Iron Deficiency ◽  
Blood Cell ◽  
Iron Deficiency Anaemia ◽  
Iron Sucrose ◽  
Ferric Carboxymaltose ◽  
Base Case ◽  
Deficiency Anaemia ◽  
Surrogate Outcomes ◽  
Iv Iron

Background Iron deficiency anaemia (IDA) is a major health issues and common type of nutritional deficiency worldwide. For IDA treatment, intravenous (IV) iron is a useful therapy. Objective To determine the efficacy and cost-effectiveness (CE) of intravenous (IV) Ferric Carboxymaltose (FCM) versus IV Iron Sucrose (IS) in treating IDA. Data sources Electronic medical record i.e. Cerner® system. Target population Adults patients with iron deficiency anaemia. Time horizon A 12-month period (01/01/2018–31/12/2018). Perspective Hamad Medical Corporation (HMC, a public hospital). Intervention IV Ferric Carboxymaltose versus IV Iron Sucrose. Outcome measures With regard to responses to treatment i.e., efficacy of treatment with FCM & IS in IDA patients, hemoglobin (Hgb), ferritin, and transferrin saturation (TSAT) levels were the primary outcomes. Additionally, the researchers also collected levels of iron, platelet, white blood cell (WBC), red blood cell (RBC), mean corpuscular hemoglobin (MCH), and mean corpuscular volume (MCV). The costs i.e. resources consumed (obtained from NCCCR-HMC) and the CE of FCM versus IS were the secondary outcomes. Results of base-case analysis There was a significant improvement in Hgb, RBC and MCH levels in the IS group than the FCM group. The overall cost of IS therapy was significantly higher than FCM. The medication cost for FCM was approximately 6.5 times higher than IS, nonetheless, it is cheaper in terms of bed cost and nursing cost. The cost effectiveness (CE) ratio illustrated that FCM and IS were significantly different in terms of Hgb, ferritin and MCH levels. Further, Incremental Cost Effectiveness Ratio (ICER) indicated that further justifications and decisions need to be made for FCM when using Hgb, iron, TSAT, MCH and MCV levels as surrogate outcomes. Results of sensitivity analysis Not applicable. Limitations The study did not consider the clinical or humanistic outcome. Conclusions The higher cost of FCM versus IS can be offset by savings in healthcare personnel time and bed space. ICER indicated that further justifications and decisions need to be made for FCM when using Hgb, iron, TSAT, MCH and MCV levels as surrogate outcomes.

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