Terminal duct adenocarcinomas of the parotid gland

AbstractThe major salivary glands are considered to rarely be the sites of primary terminal duct adenocarcinomas, a neoplasm with a considerable predilection for origin from intraoral minor salivary glands. We present a clinicopathological study of 22 terminal duct adenocarcinomas of the parotid gland, the largest single series to date. A comparison between the parotid neoplasms and over 200 minor salivary gland terminal duct adenocarcinomas indicates there is little difference in biological behaviour and confirms the low-grade quality of the carcinomas, regardless of site of origin.

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Polymorphous low grade adenocarcinoma of the parotid gland: A case report with cytohistological correlation and its immunohistochemical study

Journal of Pathology of Nepal ◽

10.3126/jpn.v2i4.6890 ◽

2012 ◽

Vol 2 (4) ◽

pp. 331-334

Author(s):

S Shrestha ◽

CB Pun ◽

R Basyal ◽

T Pathak ◽

S Bastola ◽

...

Keyword(s):

Salivary Gland ◽

Case Report ◽

Parotid Gland ◽

Salivary Glands ◽

Malignant Tumor ◽

Immunohistochemical Study ◽

Low Grade ◽

Minor Salivary Glands ◽

Major Salivary Glands

Polymorphous low-grade adenocarcinoma is a rare salivary gland malignant tumor of low aggressiveness, commonly occurring in minor salivary glands. Its origin in major salivary glands is considered exceedingly rare. We report a case of polymorphous low grade adenocarcinoma arising from left parotid in a 21-yearold female patient.Journal of Pathology of Nepal (2012) Vol. 2, 331-334DOI: http://dx.doi.org/10.3126/jpn.v2i4.6890

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An unusual pleomorphic adenoma

RGO - Revista Gaúcha de Odontologia ◽

10.1590/1981-86372014000300000141930 ◽

2014 ◽

Vol 62 (3) ◽

pp. 319-324

Author(s):

Christiano Sampaio QUEIROZ ◽

Roberto Almeida de AZEVEDO ◽

Antonio Irineu TRINDADE NETO ◽

Caetano Guilherme Carvalho PONTES ◽

Rafael de Queiroz MOURA

Keyword(s):

Salivary Gland ◽

Salivary Glands ◽

Pleomorphic Adenoma ◽

Histopathological Examination ◽

Minor Salivary Gland ◽

Surgical Excision ◽

Biological Behavior ◽

Surgical Removal ◽

Minor Salivary Glands ◽

Recommended Treatment

Pleomorphic adenoma is the most common neoplasm in major and minor salivary glands. It constitutes approximately 90% of all benign salivary gland lesions and the parotid is the most affected location. When the minor salivary glands are affected, it mostly occurs at the junction of the hard and soft palates. The diagnosis is complex because of the great histological variety and biological behavior of this tumor, a histopathological examination being essential. The recommended treatment is surgical excision. For lesions located superficially in the parotid gland, superficial parotidectomy - identifying and preserving the facial nerve - is necessary. Lesions in the palate or gums sometimes demand a margin of safety, being excised below the periosteum, including the overlying mucosa. With correct surgical removal, the prognosis is excellent. The aim of this study is to report a case of an unusual minor salivary gland pleomorphic adenoma in the hard palate, describing the most important aspects of this pathology.

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Pleomorphic Adenoma of Minor Salivary Gland in Buccal Mucosa: an Uncommon Finding

Dental Journal of Advance Studies ◽

10.1055/s-0038-1672013 ◽

2015 ◽

Vol 03 (01) ◽

pp. 047-050

Author(s):

Gourav Ahuja ◽

Jaideep Marya ◽

Poonam Sood

Keyword(s):

Salivary Gland ◽

Salivary Glands ◽

Pleomorphic Adenoma ◽

Buccal Mucosa ◽

Minor Salivary Gland ◽

Salivary Gland Tumors ◽

Benign Tumors ◽

Minor Salivary Glands ◽

Diverse Range ◽

Neck Tumors

AbstractSalivary gland tumors account for less than 3% of the head and neck tumors. Among various salivary gland tumors, pleomorphic adenoma is most common and accounts for 60- 70% of the benign tumors of salivary glands. However, the involvement of minor salivary glands of buccal mucosa is extremely uncommon and reported to be 4% only. Salivary glands may present with a diverse range of lesions presenting a challenge to even the most experienced clinician. We report two rare cases of pleomorphic adenoma of minor salivary glands of buccal mucosa in a 45 year old female and 70 years old male respectively. It includes clinical features, diagnosis and treatment of the tumor.

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Salivary Duct Cyst: Histo-pathologic Correlation

Journal of Clinical Imaging Science ◽

10.4103/2156-7514.111236 ◽

2013 ◽

Vol 3 ◽

pp. 3 ◽

Cited By ~ 5

Author(s):

Divya Vinayachandran ◽

Sathasivasubramanian Sankarapandian

Keyword(s):

Salivary Gland ◽

Parotid Gland ◽

Salivary Glands ◽

Minor Salivary Glands ◽

Salivary Duct ◽

Duct Cyst ◽

Superficial Lobe ◽

Salivary Duct Cyst ◽

Left Parotid Gland ◽

Histopathologic Features

Non-neoplastic cysts of the salivary glands are uncommon and represent 2-5% of all salivary gland lesions. They are mainly mucoceles or salivary duct cysts. Unlike a mucocele, which is surrounded by granulation tissue, the salivary duct cyst is lined by epithelium. Salivary duct cysts are more common in the oral minor salivary glands and rarely occur in the major salivary glands, show a marked predilection for the superficial lobe of the parotid, and represent 10% of all salivary gland cysts. Neoplastic differentiation of the lining of the salivary duct cyst has been reported. We report a case of a salivary duct cyst of the left parotid gland, with a review of radiographic and histopathologic features.

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Oncocytes in Mucoepidermoid Carcinoma of the Palate: Diagnostic Challenges

Case Reports in Dentistry ◽

10.1155/2017/5741821 ◽

2017 ◽

Vol 2017 ◽

pp. 1-4

Author(s):

Rammohan Kumar ◽

Srikant Natarajan ◽

K.S. Sneha ◽

Nunna Sai Chitra ◽

Karen Boaz ◽

...

Keyword(s):

Differential Diagnosis ◽

Salivary Gland ◽

Salivary Glands ◽

Mucoepidermoid Carcinoma ◽

Good Prognosis ◽

Salivary Gland Tumour ◽

Diagnostic Workup ◽

Low Grade ◽

Minor Salivary Glands ◽

Gland Tumour

The origin of a salivary gland tumour is attributed to cells at various levels of differentiation which present histologically as diverse tissues and cellular patterns. Mitochondria-rich, eosinophilic oncocytes are cells commonly encountered in salivary gland neoplasms. We report a case of mucoepidermoid carcinoma (MEC) in the palate of a 43-year-old female that exhibited a prominent oncocytic component. While the parotid and submandibular glands have been reported as predominant sites for oncocytic MEC (OMEC), the palate and minor salivary glands are rare sites for occurrence. Also, most of the reported cases of OMEC have been histologically of low-grade mucoepidermoid carcinoma with large cystic spaces and good prognosis. In this article, we discuss the differential diagnosis and diagnostic workup of an MEC presenting with oncocytes.

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Clinicopathological profile of adenoid cystic carcinoma of minor salivary gland tumour: our experience at a tertiary care centre

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20203195 ◽

2020 ◽

Vol 6 (8) ◽

pp. 1460

Author(s):

Prakash Mylanahalli Doddrangaiah ◽

Bharath Kanna Karunakaran ◽

Roopa S. Mallali ◽

Afshan Fathima

Keyword(s):

Salivary Gland ◽

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Hard Palate ◽

Minor Salivary Gland ◽

Salivary Gland Tumour ◽

Minor Salivary Glands ◽

Adenoid Cystic ◽

Minor Salivary Gland Tumour ◽

Gland Tumour

Background: Adenoid cystic carcinoma (ACC) is a rare malignant tumour originating from minor salivary glands. It is known for perineural spread, local recurrences and distant metastasis. The minor salivary gland tumour represents 3% of all head and neck neoplasms, whereas ACC constitutes about 0.5% of all malignant salivary gland neoplasms. This study was done to evaluate the clinical presentation and histopathological findings of minor salivary gland tumour.Methods: This study was done in the department of ENT, Bangalore Medical College and Research Institute from May 2017 to July 2019. Of the 25 patients with minor salivary gland tumour, 10 patients with ACC were considered for the present study. A detailed clinical and histopathological evaluation was done. Results were documented and tabulated in excel sheet. Results: We analysed data of 25 (16 female, 9 male) patients in the age group of 30-60 years, of which 10 patients had adenoid cystic carcinoma of minor salivary gland tumour. The most frequent site of tumour occurrence was noted in the hard palate (6 patients), followed by retromolar trigone (2 patients), floor of mouth (1 patient) and tongue (1 patient). The histopathological pattern noted most commonly in our study: cribriform pattern (6 cases), tubular (1 case) and solid (3 cases).Conclusions: ACC of minor salivary glands is rare. The otorhinolaryngologist should bear this clinical entity in mind when encountered with a painless swelling over the hard palate. This would lead to an early diagnosis and prompt management in such patients.

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Peculiar histopathological features in minor salivary gland in lupus erythematosus

Lupus ◽

10.1177/0961203318790672 ◽

2018 ◽

Vol 27 (10) ◽

pp. 1706-1711 ◽

Cited By ~ 2

Author(s):

S B Bologna ◽

M M S Nico ◽

G Florezi ◽

W S Cavalcante ◽

S V Lourenço

Keyword(s):

Salivary Gland ◽

Salivary Glands ◽

Lupus Erythematosus ◽

Inflammatory Infiltrate ◽

Minor Salivary Gland ◽

Control Group ◽

Minor Salivary Glands ◽

Vacuolar Degeneration ◽

Ductal Cells ◽

American College Of Rheumatology

Salivary glands (SGs) can be affected by lupus erythematosus (LE). Many authors debate whether this condition is a secondary manifestation of Sjögren syndrome (SS) or a glandular aspect of LE. The present study investigated the histopathological aspects of biopsied minor salivary glands from LE patients to analyze their peculiar features that lead to xerostomia. Twenty-three minor labial salivary gland (MLSG) cases were included in the study; the diagnosis of LE was rendered according to the American College of Rheumatology criteria. Twenty-three healthy MLSGs were used as a control, for comparison. Regarding lupus MLSG, the presence of hyalinization and thickening of ductal basement membrane, perivascular inflammatory infiltrate, epithelial spongiosis with no ductal lymphocytic aggression, vacuolar degeneration of the ductal cells and acinar serous metaplasia were statistically significant compared to the control group. In the LE group, there was a statistically significant correlation between acinar atrophy and acinar fibrosis; acinar atrophy and ductal ectasia; acinar fibrosis and ductal ectasia; ductal atrophy and ductal spongiosis with no lymphocytic focus, interstitial inflammatory infiltrate intensity and vasculitis as well as vascular thrombi and vasculitis. There were no morphological differences between the three subtypes of lupus analyzed. Minor salivary glands from patients diagnosed with LE present peculiar histopathological changes and may be a multisystemic presentation.

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Basal cell adenocarcinoma of the tongue- A rarity Case report

ARS Medica Tomitana ◽

10.1515/arsm-2017-0034 ◽

2017 ◽

Vol 23 (4) ◽

pp. 184-188

Author(s):

Ananya Madiyal ◽

Babu G. Subhas ◽

Vidya Ajila ◽

Shruthi Hegde

Keyword(s):

Salivary Gland ◽

Salivary Glands ◽

Basal Cell ◽

Low Grade ◽

Basal Cell Adenoma ◽

Minor Salivary Glands ◽

Rare Presentation ◽

Cell Adenoma ◽

Basal Cell Adenocarcinoma ◽

Salivary Gland Tumours

Abstract Basal cell adenocarcinoma is an unusual basaloid tumour that usually affects the parotid and very rarely involves the submandibular or minor salivary glands. It constitutes 1.6% of all salivary gland tumours and occurs as an asymptomatic freely mobile mass with occasional lymph node metastasis. Differentiation from benign salivary gland tumours like basal cell adenoma is accomplished by determining the depth of tumour invasion and patterns of growth or infiltration. Although it is categorised as a low-grade malignancy, it has a high propensity for recurrence. Surgical excision with a wide margin is the preferred course of treatment with radiotherapy being reserved only for tumours of the minor salivary glands with a diffuse pattern of infiltration. We present here a case of basal cell adenocarcinoma with a rare presentation in the minor salivary glands of the tongue which arose from a previously treated basal cell adenoma in the same site.

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Minor salivary gland inflammation in Devic’s disease and longitudinally extensive myelitis

Multiple Sclerosis Journal ◽

10.1177/1352458508088941 ◽

2008 ◽

Vol 14 (6) ◽

pp. 809-814 ◽

Cited By ~ 35

Author(s):

A Javed ◽

R Balabanov ◽

BGW Arnason ◽

TJ Kelly ◽

NJ Sweiss ◽

...

Keyword(s):

Salivary Gland ◽

Salivary Glands ◽

Minor Salivary Gland ◽

Connective Tissue Diseases ◽

Transverse Myelitis ◽

Minor Salivary Glands ◽

Minor Salivary Gland Biopsy ◽

Devic’S Disease ◽

Devic's Disease ◽

Sjögren’S Disease

Devic’s disease is often considered as a variant of multiple sclerosis (MS). However, evidence suggests that Devic’s disease may be distinct from MS. Devic’s disease can coexist with connective tissue diseases, particularly Sjögren’s disease, but this association is rare with MS. Diagnosis of Sjögren’s disease in patients with neurological symptoms is often difficult. During early stages of Sjögren’s disease, patients may not fulfill all criteria for Sjögren’s disease. A high percentage of patients with Sjögren’s disease have inflammatory infiltrates in minor salivary glands, and this may be a reliable indicator of early or subclinical disease. We show high prevalence (80%) of salivary gland inflammation in Devic’s disease and longitudinally extensive transverse myelitis (LETM). We diagnosed 16 patients with Devic’s disease, and 2 of these satisfied criteria for Sjögren’s disease as did 2 of 9 patients with LETM. Anti-SSA/B titers were infrequently elevated. Although most did not satisfy criteria for Sjögren’s disease. 9 of 12 Devic’s disease patients and 7 of 8 LETM patients had severe salivary gland inflammation. Thus: (1) patients with Devic’s disease or with LETM who have positive labial biopsies but do not satisfy criteria for Sjögren’s disease could have subclinical Sjögren’s diseases. Alternatively, (2) as patients with Devic’s disease have elevated titers of several autoantibodies, so there may exist a set of antibodies that react with antigens in minor salivary glands and cause inflammation. Minor salivary gland biopsy is more sensitive than anti-SSA/B serology in providing histological evidence for possible Sjögren’s disease with CNS lesions.

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