Prediction of latency interval of labour in preterm premature rupture of membranes by 2D ultrasound : Case control study

Abstract Background The neutrophil-lymphocyte ratio (NLR) is easily calculated blood test parameter, which can be used as marker to predict many inflammatory disorders. The aim of this study was to assess and compare the NLR in maternal blood with the white blood cell (WBC) count and C-reactive protein (CRP) concentration for the prediction of histological chorioamnionitis. Methods This was a case-control study of 137 woman with preterm premature rupture of membranes (PPROM) at a gestational age between 22+ 0 and 34+ 6 weeks. Blood samples, collected less than 48 h before delivery and at least 48 h after the administration of corticosteroids, were selected for the analysis. The NLR was calculated by dividing the number of neutrophils by the number of lymphocytes. Chorioamnionitis was diagnosed by the histopathological evaluation of placental membranes and chorionic plate. Results Patients with diagnosed histological chorioamnionitis (HCA) had significantly higher levels of WBC, CRP and NLR (p-value < 0.001). Levels of WBC, CRP and NLR predicted HCA with an area under the curve (AUC) of 0.81, 0.81 and 0.89, respectively. NLR had statistically significantly higher AUC than WBC, but no significant difference was found between AUCs of NLR and CRP. The cut-off level of NLR was found to be 5,97, which had a sensitivity of 77 % and a specificity of 95 %. Conclusion NLR has a good predictive value for HCA and could be used as an additional diagnostic marker for predicting histological chorioamnionitis in cases with preterm premature rupture of membranes before 34 weeks of gestation.

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Risk factors for preterm premature rupture of fetal membranes: A multicenter case-control study

American Journal of Obstetrics and Gynecology ◽

10.1016/s0002-9378(11)90686-3 ◽

1990 ◽

Vol 163 (1) ◽

pp. 130-137 ◽

Cited By ~ 157

Author(s):

James H. Harger ◽

Ann W. Hsing ◽

Ruth E. Tuomala ◽

Ronald S. Gibbs ◽

Philip B. Mead ◽

...

Keyword(s):

Risk Factors ◽

Case Control Study ◽

Case Control ◽

Fetal Membranes ◽

Premature Rupture ◽

Preterm Premature Rupture ◽

Control Study

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Effect of third-trimester premature rupture of membranes on fetal breathing movements: A prospective case-control study

American Journal of Obstetrics and Gynecology ◽

10.1016/0002-9378(88)90577-7 ◽

1988 ◽

Vol 159 (6) ◽

pp. 1474-1477 ◽

Cited By ~ 15

Author(s):

Asko I. Kivikoski ◽

Erol Amon ◽

Pentti O. Vaalamo ◽

Jouko Pirhonen ◽

Mazie M. Kopta

Keyword(s):

Case Control Study ◽

Case Control ◽

Premature Rupture Of Membranes ◽

Third Trimester ◽

Premature Rupture ◽

Fetal Breathing ◽

Fetal Breathing Movements ◽

Control Study ◽

Prospective Case Control Study

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Risk factors for previable premature rupture of membranes or advanced cervical dilation: A case control study

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2005.12.017 ◽

2006 ◽

Vol 194 (4) ◽

pp. 1168-1174 ◽

Cited By ~ 17

Author(s):

Sarah J. Kilpatrick ◽

Rajita Patil ◽

Jeness Connell ◽

Jessica Nichols ◽

Laura Studee

Keyword(s):

Risk Factors ◽

Case Control Study ◽

Case Control ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Cervical Dilation ◽

Control Study

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Interleukin-18 gene polymorphism in pregnancy With premature rupture of membranes: A case-control study

Kuban Scientific Medical Bulletin ◽

10.25207/1608-6228-2021-28-2-144-156 ◽

2021 ◽

Vol 28 (2) ◽

pp. 144-156

Author(s):

I. O. Bushtyreva ◽

N. B. Kuznetsova ◽

M. P. Dmitrieva ◽

E. V. Mashkina ◽

O. S. Oksenyuk ◽

...

Keyword(s):

Pregnant Women ◽

Case Control Study ◽

Gene Promoter ◽

Case Control ◽

Multiple Gestation ◽

Interleukin 18 ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Extremely Preterm ◽

Control Study

Background. Imbalanced pro- and anti-inflammatory systems can unfavourably condition carrying of pregnancy and provoke gestation complications, such as premature rupture of membranes.Objectives. Assessing the contribution of SNP variants -137G>C (rs187238), -607G>T (rs1946518) and -656A>C (rs5744228) of the IL-18 gene promoter to the incidence of extremely preterm premature rupture of membranes.Methods. A case-control study enrolled 120 pregnant women managed at the Perinatal Centre. The women were divided in two cohorts. The study cohort comprised 80 women with premature rupture of membranes at 22–27 weeks 6 days’ gestation hospitalised in a high-risk pregnancy unit, a control cohort consisted of 40 women with physiological pregnancy at 22–27 weeks 6 days’ gestation following outpatient counselling. The cohorts had comparable obstetric and gynaecological histories. The study exclusion criteria were: multiple gestation, foetal chromosomal anomalies, congenital foetal malformations, pregnancy due to assisted reproduction. Genotyping was performed at positions -137G>C, -607G>T and -656A>C of the IL-18 gene promoter with determining a peripheral blood IL-18 level in cohorts.Results. The premature rupture of membranes cohort had a statistically higher serum interleukin-18 concentration compared to control (p = 0.001). Genotyping of the IL-18 gene promoter revealed a statistically higher rate of homozygous -137G>C mutation (CC genotype) in the premature rupture of membranes cohort at 22–27 weeks 6 days’ term (p <0.001), 67 vs. 27% in control.Conclusion. A homozygous IL-18 -137G>C polymorphic variant associated with elevated blood IL-18 levels is statistically more common in pregnant women having premature rupture of membranes at 22–27 weeks 6 days’ gestation.

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Risk factors related to premature rupture of membranes in term pregnant women: a case-control study

Australian and New Zealand Journal of Obstetrics and Gynaecology ◽

10.1111/j.1479-828x.2000.tb03162.x ◽

2000 ◽

Vol 40 (1) ◽

pp. 30-32 ◽

Cited By ~ 5

Author(s):

Ekachai Kovavisarach ◽

Patipan Sermsak

Keyword(s):

Risk Factors ◽

Pregnant Women ◽

Case Control Study ◽

Case Control ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Control Study

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Interdelivery Interval and Medically Indicated Preterm Delivery

American Journal of Perinatology ◽

10.1055/s-0038-1667031 ◽

2018 ◽

Vol 36 (01) ◽

pp. 086-089

Author(s):

William Grobman ◽

Annie Dude

Keyword(s):

Preterm Delivery ◽

Preterm Labor ◽

Case Control Study ◽

Placental Abruption ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Preterm Premature Rupture ◽

Spontaneous Preterm Delivery ◽

Medical Indications ◽

Control Study

Objective The objective of this study was to examine whether a medically indicated preterm delivery is relatively more likely following longer interdelivery intervals. Study Design This is a case–control study of women with two consecutive deliveries of a live singleton at the same institution between 2005 and 2015, with the subsequent delivery occurring preterm. Preterm deliveries were classified as spontaneous if women delivered following preterm labor, preterm premature rupture of membranes, or placental abruption. Preterm deliveries were classified as medically indicated if women underwent delivery for fetal or maternal medical indications. Interdelivery interval was categorized as < 18, 18 to 59, and 60 months or more. Characteristics of women who had a medically indicated versus spontaneous preterm delivery were compared. Results Of the 1,276 women, 25.6% had a medically indicated preterm delivery and 74.4% had a spontaneous preterm delivery. Compared with women with an interdelivery interval of 18 to 59 months (of whom 25.7% had a preterm delivery for medical indications), women with a shorter interdelivery interval were less likely (19.3%), while women with a longer interdelivery interval were more likely (37.4%; p = 0.003) to have a medically indicated preterm delivery. This relationship persisted even when accounting for other factors. Conclusion Preterm deliveries are more likely to be medically indicated as the interdelivery interval lengthens.

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