Effects of Gamma Radiation on Poly(vinyl alcohol)/ Poly(vinyl pyrrolidone)/Nickel nanocomposite Films and Evaluation of its Dosimetric Characteristics

Background: The addition of nanofillers to polymers for enhanced performance is delivering more interesting applications for aerospace, aeronautic industries, and other numerous nano-technical applications. Objective: The aim was therefore to examine the role of graphene nanopowder on the thermal stability and conductivity of the poly(vinyl alcohol)/poly(vinyl pyrrolidone) (PVA/PVP) polymer nanocomposites. Methods: In this work, graphene nanofillers were incorporated into the PVA/PVP polymer blended by solution mixing for the preparation of nanocomposite films. Results: Results showed that; increasing graphene ratio improved thermal conductivity up to 330%, moreover enhancing hardness shore A up to 16.3% compared to pure PVA/PVP blend polymer. TGA analysis confirmed that the PVA/PVP and graphene network showed good thermal stability. Conclusion: From the present findings, it is proved that PVA/PVP blends have profound effects on thermal stability that cannot be attained by using individual counterparts. The property of the nanocomposite depends on the host blend, morphology, and interfacial characteristics.

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Characterization of Poly(Vinyl Alcohol) and Poly(Vinyl Pyrrolidone) Co-polymer Blend Hydrogel Prepared by Application of Gamma Radiation

Polymer-Plastics Technology and Engineering ◽

10.1080/03602550802129528 ◽

2008 ◽

Vol 47 (7) ◽

pp. 662-665 ◽

Cited By ~ 14

Author(s):

M. Kamal Hossen ◽

M. Alaul Azim ◽

A. M. Sarwaruddin Chowdhury ◽

N. C. Dafader ◽

M. E. Haque ◽

...

Keyword(s):

Gamma Radiation ◽

Polymer Blend ◽

Vinyl Alcohol ◽

Vinyl Pyrrolidone ◽

Poly Vinyl Alcohol ◽

Poly Vinyl Pyrrolidone

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Poly(vinyl alcohol) and poly(vinyl pyrrolidone) blended films for local nitric oxide release

Biomaterials ◽

10.1016/j.biomaterials.2003.10.035 ◽

2004 ◽

Vol 25 (17) ◽

pp. 3773-3782 ◽

Cited By ~ 109

Author(s):

Amedea Barozzi Seabra ◽

Marcelo Ganzarolli de Oliveira

Keyword(s):

Nitric Oxide ◽

Vinyl Alcohol ◽

Vinyl Pyrrolidone ◽

Poly Vinyl Alcohol ◽

Nitric Oxide Release ◽

Poly Vinyl Pyrrolidone

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PREPARATION AND CHARACTERIZATION OF POLY (VINYL ALCOHOL)–POLY (VINYL PYRROLIDONE) MUCOADHESIVE BUCCAL PATCHES FOR DELIVERY OF LIDOCAINE HCL

International Journal of Applied Pharmaceutics ◽

10.22159/ijap.2018v10i1.23208 ◽

2018 ◽

Vol 10 (1) ◽

pp. 115 ◽

Cited By ~ 5

Author(s):

Napaphak Jaipakdee ◽

Thaned Pongjanyakul ◽

Ekapol Limpongsa

Keyword(s):

Vinyl Alcohol ◽

Vinyl Pyrrolidone ◽

Poly Vinyl Alcohol ◽

Scanning Calorimetry ◽

X Ray ◽

Casting Technique ◽

In Vitro Permeation ◽

Lidocaine Hcl ◽

Poly Vinyl Pyrrolidone

Objective: The objectives of this study were to prepare and characterize a buccal mucoadhesive patch using poly (vinyl alcohol) (PVA), poly (vinyl pyrrolidone) (PVP) as a mucoadhesive matrix, Eudragit S100 as a backing layer, and lidocaine HCl as a model drug.Methods: Lidocaine HCl buccal patches were prepared using double casting technique. Molecular interactions in the polymer matrices were studied using attenuated total reflectance-fourier transform infrared spectroscopy (ATR-FTIR), differential scanning calorimetry (DSC) and X-ray diffractometry. Mechanical and mucoadhesive properties were measured using texture analyzer. In vitro permeation of lidocaine HCl from the patch was conducted using Franz diffusion cell.Results: Both of the free and lidocaine HCl patches were smooth and transparent, with good flexibility and strength. ATR-FTIR, DSC and X-ray diffractometry studies confirmed the interaction of PVA and PVP. Mechanical properties of matrices containing 60% PVP were significantly lower than those containing 20% PVP (*P<0.05). Mucoadhesive properties had a tendency to decrease with the concentration of PVP in the patch. The patch containing 60% PVP had significantly lower muco-adhesiveness than those containing 20% PVP (*P<0.05). In vitro permeation revealed that the pattern of lidocaine HCl permeation started with an initial fast permeation, followed by a slower permeation rate. The initial permeation fluxes follow the zero-order model of which rate was not affected by the PVP concentrations in the PVA/PVP matrix.Conclusion: Mucoadhesive buccal patches fabricated with PVA/PVP were successfully prepared. Incorporation of PVP in PVA/PVP matrix affected the strength of polymeric matrix and mucoadhesive property of patches.

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