Time and dose-dependent adverse effects of four medicinal plants on male reproductive system

2017 ◽  
Vol 7 (4) ◽  
pp. 136-142
2017 ◽  
Vol 7 (4) ◽  
pp. 136-142
Author(s):  
Ehsanollah Sakhaee ◽  
Ladan Emadi ◽  
Heydar Bagaloy ◽  
Najma Abbasi

2019 ◽  
Vol 248 (3) ◽  
pp. 169-179 ◽  
Author(s):  
Farah Hanan Fathihah Jaffar ◽  
Khairul Osman ◽  
Nur Hilwani Ismail ◽  
Kok-Yong Chin ◽  
Siti Fatimah Ibrahim

2019 ◽  
Vol 10 (3) ◽  
pp. 2515-2518
Author(s):  
Ruby Philip ◽  
Kathiresan Krishnasamy ◽  
Elessy Abraham

Medicinal plants are important resources for the development of novel anti-inflammatory agents. Synthetic anti-inflammatory drugs have several adverse effects. Medicinal plants have numerous that are safer well as better substitutes for the prevention and management of various diseases and disorders. The and ethyl acetate extracts of Jasminum were evaluated for their potential as anti-inflammatory agents in by inducing paw edema in rats using . The anti-inflammatory activity of the reference drug was compared with the extracts of Jasminum . The extracts on screening indicated the presence of such as , , , alkaloids, and . The study established significant anti-inflammatory nature of the Jasminum extracts in a manner which is dose-dependent. The results indicate that both the extracts of Jasminum possess anti-inflammatory activity of significance and can be used in the development for novel anti-inflammatory moieties.


Biomedicines ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 1744
Author(s):  
Asma’ ‘Afifah Shamhari ◽  
Zariyantey Abd Hamid ◽  
Siti Balkis Budin ◽  
Nurul Jehan Shamsudin ◽  
Izatus Shima Taib

BPA is identified as an endocrine-disrupting chemical that deteriorates the physiological function of the hormones of the male reproductive system. Bisphenol F (BPF), bisphenol S (BPS), and bisphenol AF (BPAF) are actively explored as substitutes for BPA and are known as BPA analogues in most manufacturing industries. These analogues may demonstrate the same adverse effects as BPA on the male reproductive system; however, toxicological data explaining the male reproductive hormones’ physiological functions are still limited. Hence, this mini-review discusses the effects of BPA and its analogues on the physiological functions of hormones in the male reproductive system, focusing on the hypothalamus-pituitary-gonad (HPG) axis, steroidogenesis, and spermatogenesis outcomes. The BPA analogues mainly show a similar negative effect on the hormones’ physiological functions, proven by alterations in the HPG axis and steroidogenesis via activation of the aromatase activity and reduction of spermatogenesis outcomes when compared to BPA in in vitro and in vivo studies. Human biomonitoring studies also provide significant adverse effects on the physiological functions of hormones in the male reproductive system. In conclusion, BPA and its analogues deteriorate the physiological functions of hormones in the male reproductive system as per in vitro , in vivo , and human biomonitoring studies.


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