WHEY SUPPLEMENTATION ALLEVIATED VENTRAL PROSTATE DAMAGE AND CIRCULATING HORMONES IN AGED RATS

2021 ◽  
Vol 50 (3) ◽  
pp. 74-85
Author(s):  
Yasmin Khalifa ◽  
Nermeen Ashry ◽  
Hassan Elsayyed ◽  
Heba El-Ghaweet
Keyword(s):  
Ventral Prostate ◽  
Aged Rats

The role of asymmetric dimethylarginine in myocardial aging of aged rats and its mechanisms

2010 ◽  
Vol 34 (8) ◽  
pp. S29-S29
Author(s):  
Ru Zhang ◽  
Yong Zhen Gong ◽  
Wen Juan Xu ◽  
Yao Pan ◽  
Yan Xiong
Keyword(s):  
Asymmetric Dimethylarginine ◽  
Aged Rats ◽  
Myocardial Aging

Butea Frondosa, A Rho Kinase 2 and Phosphodiesterase 5 Enzyme Inhibitor, Increases Sexual Function In Young And Aged Rats

Planta Medica ◽  
2013 ◽  
Vol 79 (10) ◽  
Author(s):  
S Kumar Goswami ◽  
M Naseeruddin Inamdar ◽  
S Dethe ◽  
A Agarwal
Keyword(s):  
Sexual Function ◽  
Enzyme Inhibitor ◽  
Rho Kinase ◽  
Aged Rats ◽  
Phosphodiesterase 5

On the Fibrinolytic System in Aged Rats, and Its Reactivity to Endotoxin and Cytokines

1992 ◽  
Vol 67 (06) ◽  
pp. 697-701 ◽  
Author(s):  
J J Emeis ◽  
A Brouwer ◽  
R J Barelds ◽  
M A Horan ◽  
S K Durham ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Fibrinolytic Activity ◽  
Fibrinolytic System ◽  
Tissue Type ◽  
High Dose ◽  
Base Line ◽  
Aged Rats ◽  
Tissue Type Plasminogen Activator ◽  
Young Rats ◽  
Type Plasminogen Activator

SummaryAged rats are more susceptible to endotoxin-induced effects, including microthrombosis and platelet aggregation, than are young rats. To investigate whether changes in the fibrinolytic system might be involved, we investigated the fibrinolytic activity in plasma euglobulin fractions and tissues (lung and heart) of young (6-months old) and aged (24-months old) rats under baseline conditions and after challenge with endotoxin. Aged rats had lower plasma levels of tissue-type plasminogen activator (t-PA) and of urokinase-type PA (u-PA) activity. PA inhibitor (PAI) activity was higher in the plasma of aged rats, as was t-PA activity in lung and heart.Rats were treated with either a low dose (1 μg/kg) or a high dose (10 mg/kg) of endotoxin. Both treatments induced a transient phase of increased blood fibrinolytic activity, as evidenced by higher levels of tissue-type plasminogen activator (t-PA) activity and decreased levels of PA inhibitor (PAI) activity. Over time, the fibrinolytic activity decreased, probably due to increased levels of PA inhibitor.Both the early increase in t-PA activity, and the subsequent increase in PAI activity, were more pronounced in the aged rats, as compared with the younger rats, after the high dose of endotoxin. The aged rats also responded to an injection of interleukin-1β or tumor necrosis factor-α with a larger increase of PAI activity than did the younger rats.Together the data suggest that, compared to young rats, aged rats have a decreased base-line plasma fibrinolytic activity, while their fibrinolytic system is more responsive to challenge by endotoxin and cytokines.

Accelerated infarct development, cytogenesis and apoptosis following cerebral ischaemia in aged rats

2006 ◽  
Vol 33 (S 1) ◽  
Author(s):  
A. Popa-Wagner ◽  
M. Sascau ◽  
Y. Suofu ◽  
C. Kessler
Keyword(s):  
Cerebral Ischaemia ◽  
Aged Rats

METABOLISM AND MODE OF ACTION OF ANDROGENS IN TARGET TISSUES OF MALE RATS

1972 ◽  
Vol 69 (1) ◽  
pp. 165-173 ◽  
Author(s):  
H. Schmidt ◽  
I. Noack ◽  
K. D. Voigt
Keyword(s):  
Cell Proliferation ◽  
Cell Metabolism ◽  
Seminal Vesicles ◽  
Male Rats ◽  
Ventral Prostate ◽  
Nucleic Acid Content ◽  
The Difference ◽  
Independent Effects ◽  
Sites Of Action ◽  
Peripheral Metabolism

ABSTRACT The effect of testosterone and 5α-dihydrotestosterone on protein and nucleic acid content as well as on the activities of some enzymes has been studied in the ventral prostate and the seminal vesicles of immature castrated rats. Both androgens were given intraperitoneally in doses of 1 mg daily for one or three days the rats were sacrificed one day after the last injection. In the prostate it was found that 5α-dihydrotestosterone had a greater effect on DNA increase, i. e. cell proliferation than testosterone, whereas cell metabolism was stimulated by the two androgens to nearly the same extent. In the seminal vesicles a single dose led to the same results as had been obtained in the prostate, i. e. a greater cell proliferative action of 5α-dihydrotestosterone and an equal stimulation of cell metabolism by testosterone and 5α-dihydrotestosterone was also observed. When three doses of the two androgens were given, cell proliferation as well as cell metabolism in the seminal vesicles were significantly more increased after 5α-dihydrotestosterone than after testosterone. The difference of action after systemic administration of the two androgens is explained by their different accumulation and by their different peripheral metabolism in the target tissues. From the partly independent effects of various androgens on cell proliferation and cell metabolism the conclusion may be drawn that there exist at least two intracellular sites of action.

Impact of Various Regimens of Rhythmic Extreme Cold Exposures on Hormone and Lipid Content in Blood Serum of Young and Aged Rats

2019 ◽  
Vol 29 (3) ◽  
pp. 206-220
Author(s):  
Volodymyr Kulik ◽  
◽  
Georgiy Babiichuk ◽  
Vladyslav Babiichuk ◽  
Natalya Malova ◽  
...  
Keyword(s):  
Blood Serum ◽  
Lipid Content ◽  
Aged Rats ◽  
Extreme Cold
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