scholarly journals Herbs and Supplements for Liver Toxicity: A Review on Mode of Action of Herbs and Supplements on Liver Toxicity

2021 ◽  
Vol 89 (9) ◽  
pp. 2179-2183
Author(s):  
SAHAR S. ATREES, Ph.D.; HEBA MOHAMMED RABIA, Ph.D.
Keyword(s):  
Mode Of Action ◽  
Liver Toxicity

scholarly journals Prediction of liver toxicity and mode of action using metabolomics in vitro in HepG2 cells

2017 ◽  
Vol 92 (2) ◽  
pp. 893-906 ◽  
Author(s):  
Tzutzuy Ramirez ◽  
Alexander Strigun ◽  
Andreas Verlohner ◽  
Hans-Albrecht Huener ◽  
Erik Peter ◽  
...  
Keyword(s):  
Mode Of Action ◽  
Hepg2 Cells ◽  
Liver Toxicity

scholarly journals Exposure of HepaRG Cells to Sodium Saccharin Underpins the Importance of Including Non-Hepatotoxic Compounds When Investigating Toxicological Modes of Action Using Metabolomics

Metabolites ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 265
Author(s):  
Matthias Cuykx ◽  
Charlie Beirnaert ◽  
Robim Marcelino Rodrigues ◽  
Kris Laukens ◽  
Tamara Vanhaecke ◽  
...  
Keyword(s):  
Cell Death ◽  
Experimental Design ◽  
Mode Of Action ◽  
Liver Toxicity ◽  
Data Interpretation ◽  
Reference Compound ◽  
Metabolic Alterations ◽  
Modes Of Action ◽  
Heparg Cells ◽  
Sodium Saccharin

Metabolites represent the most downstream information of the cellular organisation. Hence, metabolomics experiments are extremely valuable to unravel the endogenous pathways involved in a toxicological mode of action. However, every external stimulus can introduce alterations in the cell homeostasis, thereby obscuring the involved endogenous pathways, biasing the interpretation of the results. Here we report on sodium saccharin, which is considered to be not hepatotoxic and therefore can serve as a reference compound to detect metabolic alterations that are not related to liver toxicity. Exposure of HepaRG cells to high levels of sodium saccharin (>10 mM) induced cell death, probably due to an increase in the osmotic pressure. Yet, a low number (n = 15) of significantly altered metabolites were also observed in the lipidome, including a slight decrease in phospholipids and an increase in triacylglycerols, upon daily exposure to 5 mM sodium saccharin for 72 h. The observation that a non-hepatotoxic compound can affect the metabolome underpins the importance of correct experimental design and data interpretation when investigating toxicological modes of action via metabolomics.

Effects of 5-5'-Diphenyl-2-thiohydantoin (DPTH) and Thyroxine on the Ultrastructure and Chemical Composition of Rat Liver

1971 ◽  
Vol 29 ◽  
pp. 570-571
Author(s):  
E. A. Elfont ◽  
R. B. Tobin ◽  
D. G. Colton ◽  
M. A. Mehlman
Keyword(s):  
Chemical Composition ◽  
Rat Liver ◽  
Future Study ◽  
Mode Of Action ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Effective Inhibitor ◽  
Biochemical Effects ◽  
Glycerophosphate Dehydrogenase ◽  
Stimulation Of

Summary5,-5'-diphenyl-2-thiohydantoin (DPTH) is an effective inhibitor of thyroxine (T4) stimulation of α-glycerophosphate dehydrogenase in rat liver mitochondria. Because this finding indicated a possible tool for future study of the mode of action of thyroxine, the ultrastructural and biochemical effects of DPTH and/or thyroxine on rat liver mere investigated.Rats were fed either standard or DPTH (0.06%) diet for 30 days before T4 (250 ug/kg/day) was injected. Injection of T4 occurred daily for 10 days prior to sacrifice. After removal of the liver and kidneys, part of the tissue was frozen at -50°C for later biocheailcal analyses, while the rest was prefixed in buffered 3.5X glutaraldehyde (390 mOs) and post-fixed in buffered 1Z OsO4 (376 mOs). Tissues were embedded in Araldlte 502 and the sections examined in a Zeiss EM 9S.Hepatocytes from hyperthyroid rats (Fig. 2) demonstrated enlarged and more numerous mitochondria than those of controls (Fig. 1). Glycogen was almost totally absent from the cytoplasm of the T4-treated rats.

Mode of action of calcimycin (A 23187) — II — A study of its interactions ith alkali and alkali-earth cations in methanol-water mixtures

1985 ◽  
Vol 82 ◽  
pp. 899-906 ◽  
Author(s):  
C. Tissier ◽  
J. Juillard ◽  
D.W. Boyd ◽  
A.M. Albrecht-Gary
Keyword(s):  
Mode Of Action ◽  
Alkali Earth ◽  
A 23187

Antibiotic mode of action profiling (Biomap) as a platform for the discovery of novel natural product antibiotics

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
W Ruh Wong ◽  
AG Oliver ◽  
RG Linington
Keyword(s):  
Natural Product ◽  
Mode Of Action

Hepatoprotective activity of the wild carrot chloroform-based fraction against CCl4-induced liver toxicity in mice

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
W Shebaby ◽  
M El-Sibai ◽  
M Mroueh ◽  
K Bodman-Smith ◽  
R Taleb ◽  
...  
Keyword(s):  
Liver Toxicity ◽  
Hepatoprotective Activity ◽  
Wild Carrot
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