scholarly journals Fibrogenic/Angiogenic Linker for Non-invasive assessment of hepatic fibrosis staging in chronic hepatitis C genotype 4 patients

2016 ◽  
Vol 2 (1) ◽  
pp. 1-14
Author(s):  
Toson E. ◽  
Shiha G. ◽  
Abdelgaleel A.
2016 ◽  
Vol 13 (1) ◽  
pp. 287-297
Author(s):  
Amr Amin ◽  
Mohammed Mukhtar ◽  
Essam NoorEldin ◽  
Fahd Gethami ◽  
Fayez Hafez ◽  
...  

2004 ◽  
Vol 19 (s7) ◽  
pp. S236-S245 ◽  
Author(s):  
THIERRY POYNARD ◽  
FRANCOISE IMBERT-BISMUT ◽  
MONA MUNTEANU ◽  
DJAMILA MESSOUS ◽  
DOMINIQUE THABUT ◽  
...  

2013 ◽  
Vol 33 (7) ◽  
pp. 982-990 ◽  
Author(s):  
Samer S. El-Kamary ◽  
Mona M. Mohamed ◽  
Maissa El-Raziky ◽  
Michelle D. Shardell ◽  
Olfat G. Shaker ◽  
...  

2012 ◽  
Vol 49 (1) ◽  
pp. 14-18 ◽  
Author(s):  
Haroldo Luis Oliva Gomes Rocha ◽  
Angélica Lemos Debs Diniz ◽  
Valéria Ferreira de Almeida e Borges ◽  
Frederico Chaves Salomão

CONTEXT: Hepatitis C is an important cause of chronic liver disease worldwide. The grading of hepatic fibrosis in chronic hepatitis C is important for better clinical management. However, until now, liver biopsy is the only test accepted for this purpose, despite their contraindications and complications. New methods for non-invasive assessment of hepatic fibrosis are under investigation. One proposal is the Doppler ultrasound, as a non-invasive, widely available and inexpensive. OBJECTIVE: To compare Doppler parameters of portal vein in patients with chronic hepatitis C with a healthy control group and to correlate these parameters with fibrosis degree obtained by liver biopsy. METHODS: Fifty patients with chronic hepatitis C submitted to liver biopsy and 44 healthy controls had Doppler of the portal vein performed, with the calculation of the portal venous index. We conducted a comparison between the averages of the two groups of portal venous index. For the correlation between portal venous index and fibrosis was employed the Spearman test. RESULTS: There was a difference between the average portal venous index between controls (0.33 ± 0.07) and patients (0.23 ± 0.09) with P<0.001. No difference was observed between the portal venous index in patients with chronic hepatitis C who have significant fibrosis or not. The correlation between the portal venous index and fibrosis degree was reverse and moderate (r =-0.448 P<0.001). The area under the ROC curve was 78.4% (95% CI: 68.8% to 88%). The cutoff for the portal venous index was 0.28 with sensitivity of 73.5% and specificity of 71.1%. CONCLUSION: The portal venous index was useful in distinguishing healthy patients from patients with CHC. However, there was no significant difference in the quantification of degree of fibrosis.


2017 ◽  
Vol 49 (12) ◽  
pp. 1338-1344 ◽  
Author(s):  
Tommaso Gabbani ◽  
Maria Marsico ◽  
Patrizia Bernini ◽  
Elisabetta Lorefice ◽  
Cecilia Grappone ◽  
...  

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