scholarly journals Targeting wingless-integrated/β-catenin (Wnt/β-catenin) signaling pathway as a new therapeutic modality

2021 ◽  
Vol 0 (0) ◽  
pp. 1-16
Author(s):  
Asmaa Abdelghafour ◽  
Nahla Younis ◽  
Sally Hammad ◽  
Hoda Mohamed
Keyword(s):  
Signaling Pathway ◽  
Therapeutic Modality

scholarly journals Autophagy blockade synergistically enhances nanosonosensitizer-enabled sonodynamic cancer nanotherapeutics

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Liqiang Zhou ◽  
Minfeng Huo ◽  
Xiaoqin Qian ◽  
Li Ding ◽  
Luodan Yu ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Early Phase ◽  
Protoporphyrin Ix ◽  
Mapk Signaling ◽  
Therapeutic Modality ◽  
Autophagy Inhibition

AbstractUltrasound-triggered sonodynamic therapy (SDT) represents an emerging therapeutic modality for cancer treatment based on its specific feature of noninvasiveness, high tissue-penetrating depth and desirable therapeutic efficacy, but the SDT-induced pro-survival cancer-cell autophagy would significantly lower the SDT efficacy for cancer treatment. Here we propose an “all-in-one” combined tumor-therapeutic strategy by integrating nanosonosensitizers-augmented noninvasive SDT with autophagy inhibition based on the rationally constructed nanoliposomes that co-encapsulates clinically approved sonosensitizers protoporphyrin IX (PpIX) and early-phase autophagy-blocking agent 3-methyladenine (3-MA). It has been systematically demonstrated that nanosonosensitizers-augmented SDT induced cytoprotective pro-survival autophagy through activation of MAPK signaling pathway and inhibition of AMPK signaling pathway, and this could be efficaciously inhibited by 3-MA in early-phase autophagy, which significantly decreased the cell resistance to intracellular oxidative stress and complied a remarkable synergistic effect on SDT medicated cancer-cell apoptosis both in vitro at cellular level and in vivo on tumor-bearing animal model. Therefore, our results provide a proof-of-concept combinatorial tumor therapeutics based on nanosonosensitizers for the treatment of ROS-resistant cancer by autophagy inhibition-augmented SDT.

Wnt signaling pathway regulates the differentiation of hepatic progenitor cells

2010 ◽  
Vol 34 (8) ◽  
pp. S41-S41
Author(s):  
Yang Bi ◽  
Yun He ◽  
Tingyu Li ◽  
Tao Feng ◽  
Tongchuan He
Keyword(s):  
Wnt Signaling ◽  
Progenitor Cells ◽  
Signaling Pathway ◽  
Wnt Signaling Pathway ◽  
Hepatic Progenitor Cells

285: The Role of the NF-κB Signaling Pathway in the Pathogenesis of Interstitial Cystitis

2006 ◽  
Vol 175 (4S) ◽  
pp. 95-95
Author(s):  
Raymond R. Rackley ◽  
Mei Kuang ◽  
Ashwin A. Vaze ◽  
Joseph Abdelmalak ◽  
Sandip P. Vasavada ◽  
...  
Keyword(s):  
Interstitial Cystitis ◽  
Signaling Pathway

417: The Human Androgen Receptor Gene is a Primary Target of the WNT Signaling Pathway

2006 ◽  
Vol 175 (4S) ◽  
pp. 136-136
Author(s):  
Ralph Buttyan ◽  
Xuezhen Yang ◽  
Min-Wei Chen ◽  
Debra L. Bemis ◽  
Mitchell C. Benson ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Receptor Gene ◽  
Wnt Signaling Pathway ◽  
Androgen Receptor Gene ◽  
Primary Target ◽  
Human Androgen Receptor Gene ◽  
Human Androgen Receptor

1451: Positive Efect of Prostaglandin on Regulation of Prostate Blood Flow-Investigation of the Key Factor in the Signaling Pathway of The Prostate Blood Flow-

2005 ◽  
Vol 173 (4S) ◽  
pp. 393-393
Author(s):  
Bunzo Kashiwagi ◽  
Yasuhiro Shibata ◽  
Kazunari Ohki ◽  
Seiji Arai ◽  
Seijiro Honma ◽  
...  
Keyword(s):  
Blood Flow ◽  
Signaling Pathway ◽  
Flow Investigation ◽  
Key Factor

P 53 and p56: A new signaling pathway in human endometrium and endometrial adenocarcinomas

1997 ◽  
Vol 4 (2) ◽  
pp. 103-109
Author(s):  
G COUCHMAN ◽  
R BENTLEY ◽  
M TSAO ◽  
K RASZMANN ◽  
J MCLACHLAN ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Human Endometrium ◽  
P 53
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