scholarly journals Peripheral Lymphadenopathy in Children, Comparison of Fine Needle Aspiration Cytology with Open Biopsy

2016 ◽  
Vol 11 (4) ◽  
Author(s):  
Mukhtar Hussain ◽  
Akram Shad Chishti ◽  
Rubina Mukhtar ◽  
Hanif Khan ◽  
Hussain Siddiqui ◽  
...  

Objective: To compare the results of Fine Needle Aspiration Cytology (FNAC) with open biopsy in cases of Peripheral Lymphadenopathy. Design: A comparative study. Place and duration of study: Department of Paediatric Surgery & Department of Pathology, Nishtar Medical College & Hospital, Multan from January 2004 to September 2004. Subjects and methods: Patients presenting with Peripheral Lymphadenopathy in Paediatric Surgery out patient department were included in study. Relevant history and clinical findings were entered in performa and patients were submitted to investigations like FNAC and open lymphnode biopsy, after getting consent, on OPD basis. Results: Results of both FNAC and histopathology in 54 patients were available for comparison at the end of study. FNAC showed tuberculosis in 36 (66.67%), lymphoproliferative process in 16 (29.63%) and poor yield in 2 (3.71%) cases. Whereas open lymphnode biopsy on histopathology confirmed tuberculosis in 42 (77.78%), Hodgkin`s lymphoma in 4.(7.42%), Non Hodgkin`s in 6 (11.13%) and reactive hyperplasia in 2 (3.71%) cases. Sensitivity of FNAC in tuberculosis was 85.7% with a specificity of 100% in cases of tuberculosis while it was 71.5% in cases of lymphomatous process with an overall sensitivity of 78.5% in peripheral lymphadenopathy. Conclusion: In our setup lymphnode biopsy should be performed in all suspected cases to avoid long term morbidity and mortality especially in clinically malignant illnesses.

Author(s):  
Bhavna G. Gamit ◽  
Mubin I. Patel ◽  
Mandakini M. Patel ◽  
Sharmistha M. Patel

Background: Fine needle aspiration cytology (FNAC) is a first line investigation in cervical swellings. The etiology varies from an inflammatory process to a malignant condition.Methods: The study was carried out in department of Pathology, Government Medical College, affiliated with government hospital in Gujarat. There were 470 patients with cervical swelling in a period from January 2017 to December 2017. Patients with thyroid swelling (swelling moves with deglutition) were excluded from the study. FNAC procedure was performed, smears prepared, stained with haematoxylin and eosin (H and E), May Grunwald Giemsa (MGG) and Pap stain. Zeihl Neelsen stain was carried out when required. Patient history, local examination findings and microscopic findings were recorded.Results: Total 470 patients, age ranged from 2 months to 90 years were studied. There were 286 males and 184 females. There were 449 cases in which conclusive opinion given. 111 cases were neoplastic and 338 cases were non-neoplastic. Various cytological diagnosis were; 207 cases of granulomatous lymphadenitis (tuberculosis), 1 case of filarial lymphadenitis, 72 cases of chronic reactive hyperplasia, 25 cases of acute suppurative inflammation, 1 case of sialadenitis, 10 cases of keratinous cyst, 6 cases of benign cystic lesion, 12 cases of lipoma, 4 cases of lymphoproliferative lesion, 1 cases of benign appendage tumor, 2 cases of mucoepidermoid carcinoma, 103 cases of metastasis and 5 cases of non Hodgkin lymphoma.Conclusions: FNAC is a simple, quick, inexpensive and minimally invasive technique to diagnose cervical swellings. It can differentiate the infective process from neoplastic one and avoids unnecessary surgeries.


2009 ◽  
Vol 16 (02) ◽  
pp. 235-238
Author(s):  
MUHAMMAD QASIM ◽  
SYED ALI AKBAR ◽  
JOHAR ALI ◽  
Saima Mustafa

B a c k g r o u n d : Lump breast is a fairly common presenting complaint for which patient seeks medical advice and becomesanxious about the diagnosis. Fine needle aspiration cytology (FNAC) for the diagnosis of lump breast has been proved as a simple, rapidand economical Procedure. The present study was done to evaluate the diagnostic accuracy of fine lump breast in our set-up comparedwith open biopsy. M e t h o d s : The study was conducted in surgical department of Nishtar Hospital Multan and Frontier Medical CollegeAbbottabad. One hundred female patients with lump breast were selected for the study and their medical history was recorded. The agerange was 15- 65 years. All of the patients under went FNAC of the lump breast followed by open biopsy for comparison. R e s u l t s : Theresults reveal that this study shows a sensitivity of 87.5% for FNAC to pick malignant lesions and specificity of 82.4% while over all diagnosticaccuracy 84%. C o n c l u s i o n s : Fine needle aspiration cytology is safe, easy, cheap and accurate procedure. Its sensitivity and specificityis fairly high and is a good alternative to open biopsy. FNAC should be routinely used and open biopsy should be performed in doubtfulcases only.


1984 ◽  
Vol 199 (5) ◽  
pp. 569-579 ◽  
Author(s):  
HAROLD J. WANEBO ◽  
PHILIP S. FELDMAN ◽  
MORTON C. WILHELM ◽  
JAMIE L. COVELL ◽  
RICHARD L. BINNS

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