Coronary Artery Vasomotion and Post-Stenotic Coronary Artery Blood Flow after Intracoronary Lacidipine in Patients with Ischaemic Heart Disease

State of the Art Surgical Coronary Revascularization is an authoritative textbook dedicated to the art and science of surgical coronary revascularization, with 71 chapters, organized in nine sections, and written by over 100 recognized world experts. The textbook covers every aspect of the surgical management of coronary artery pathology and ischaemic heart disease. It provides extensive sections detailing pathophysiology, evaluation, and medical and percutaneous management of ischaemic heart disease as well as general outcomes and quality assessment for coronary artery bypass grafting. Pre-, intra- and postoperative management of coronary artery bypass graft patients is emphasized in detail as are the core surgical principles in the conduct of coronary artery bypass grafting, with special focus on the selection of conduits and how to optimize the performance of both on- and off-pump surgery to reduce morbidity and mortality. There are detailed sections on how to improve outcomes with both arterial and venous bypass grafts.

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Ischaemic heart disease in women

ESC CardioMed ◽

10.1093/med/9780198784906.003.0679 ◽

2018 ◽

pp. 2836-2840

Author(s):

Martha Gulati

Keyword(s):

Myocardial Infarction ◽

Coronary Artery Disease ◽

Heart Disease ◽

Coronary Artery ◽

Ischaemic Heart Disease ◽

Obstructive Coronary Artery Disease ◽

Diagnostic Testing ◽

Atypical Presentation ◽

Artery Disease

The more atypical presentation of women makes the diagnostic evaluation of symptomatic women challenging and results in more frequent referral for diagnostic testing to improve the precision of the ischaemic heart disease likelihood estimate. The classification of ischaemic heart disease and myocardial infarction has moved beyond the diagnosis of obstructive coronary artery disease and encompasses ischaemia that can occur in the presence and absence of obstructive coronary artery disease. Consideration of the different pathophysiology of ischaemia that may occur in women needs to be considered in the evaluation and treatment of ischaemic heart disease in women.

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Clinical significance of presenting syndromes on outcome after coronary artery bypass grafting

Interactive CardioVascular and Thoracic Surgery ◽

10.1093/icvts/ivz259 ◽

2019 ◽

Vol 30 (2) ◽

pp. 243-248

Author(s):

Syed Usman Bin Mahmood ◽

Makoto Mori ◽

Sameh Yousef ◽

Clancy W Mullan ◽

Abeel A Mangi ◽

...

Keyword(s):

Heart Disease ◽

Coronary Artery ◽

Ischaemic Heart Disease ◽

Artery Bypass ◽

Bypass Grafting ◽

Cox Proportional Hazard Model ◽

Proportional Hazard ◽

Proportional Hazard Model ◽

Term Survival ◽

Cox Proportional Hazard

Abstract OBJECTIVES Evidence of an association between postoperative survival and the presenting syndrome following coronary artery bypass grafting (CABG) is limited. Our goal was to evaluate whether the presenting symptoms of acute coronary syndrome (ACS) or stable ischaemic heart disease were associated with mid-term survival in patients undergoing CABG. METHODS We performed a single-centre retrospective study involving consecutive CABG operations from 2011 to 2016. Post-discharge survival was ascertained via patient-level data linkage with the State of Connecticut vital statistics. Baseline and postoperative variables were compared between the two groups. The multivariate Cox proportional hazard model, adjusted for demographics and comorbidity, was used to show whether the presenting syndrome category was independently associated with mid-term survival. RESULTS A total of 1631 patients were included: 794 with stable ischaemic heart disease and 837 with ACS. Patients with ACS who underwent CABG showed more comorbidities. The overall 30-day mortality rate was 1.8% (ACS 2.3% vs stable ischaemic heart disease 1.3%; P = 0.12). In-hospital, postoperative outcomes revealed higher rates of prolonged ventilation (11.7% vs 4.8%; P < 0.001), pneumonia (6.6% vs 3.9%; P = 0.016) and stay in the intensive care unit (3.7 ± 4.0 vs 3.2 ± 2.7 days; P = 0.014) in patients with ACS. The overall mean duration of the long-term follow-up period was 27.9 ± 16.5 months, during which 117 deaths occurred. The multivariable Cox proportional hazard model adjusted for demographics and comorbidity showed that ACS was not a predictor of mid-term mortality [hazard ratio (HR) 1.26, 95% confidence interval (CI) 0.84–1.90; P = 0.26]. Other significant predictors were cardiogenic shock (HR 2.12, 95% CI 1.04–4.33; P = 0.039) and history of congestive heart failure (HR 1.78, 95% CI 1.18–2.69; P = 0.0062). CONCLUSIONS The presenting syndrome was not an independent predictor of the mid-term mortality rate. The results indicate that the classification of the presenting syndrome may be fluid and that clinical decision-making for postoperative care of patients who have CABG directed by category of presenting syndrome needs careful consideration. These data should be interpreted in the context of the limitations of this study.

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Central haemodynamics and coronary artery blood flow after administration of pentoxifylline to patients with coronary artery disease. A preoperative study

Theophylline and other Methylxanthines / Theophyllin und andere Methylxanthine ◽

10.1007/978-3-663-05268-5_30 ◽

1982 ◽

pp. 233-243

Author(s):

S. Ekeström ◽

L. Liljeqvist ◽

O. Nordhus

Keyword(s):

Coronary Artery Disease ◽

Blood Flow ◽

Coronary Artery ◽

Artery Blood Flow ◽

Artery Disease

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Coronary Angiographic Severity in Patients With Raised Plasma Homocysteine Level

Cardiovascular Journal ◽

10.3329/cardio.v1i2.8124 ◽

1970 ◽

Vol 1 (2) ◽

pp. 169-173 ◽

Cited By ~ 1

Author(s):

MS Kabir ◽

AAs Majumder ◽

MS Bari ◽

AW Chowdhury ◽

AM Islam

Keyword(s):

Coronary Artery Disease ◽

Heart Disease ◽

Coronary Artery ◽

Ischaemic Heart Disease ◽

Homocysteine Level ◽

Plasma Homocysteine ◽

Plasma Homocysteine Level ◽

Vessel Disease ◽

Artery Disease ◽

Single Vessel Disease

Background: Besides conventional classic risk factors of ischaemic heart disease other variables that have come under scrutiny for their potential contribution include estrogen deficiency, lipoprotein (a), plasma fibrinogen, plasminogen-activator inhibitor type I, endogenous tissue plasminogen activator (tPA), C-reactive protein and homocysteine. A number of studies have been undertaken worldwide shows strong correlation of raised fasting plasma homocysteine level with the development of atherosclerotic vascular diseases, myocardial infarction or increasing severity of coronary artery diseases. Objective: To find out the correlation of fasting plama homocysteine level with the severity of coronary artery disease in our population. Method: We undertook a study involving 100 patients of ischaemic heart disease (determined clinically & by non-invasive tests) in National Institute of Cardiovascular Diseases, Dhaka, Bangladesh, over the period of one year from January 2003 to December 2003. Out of 100 patients, 50 patients having normal homocysteine level were considered as control and another 50 patients having raised plasma homocysteine level were taken as cases. Result: Out of 50 patients, 20% had single vessel disease, 48% had double vessel disease and 32% had 3 vessel diseases. On the other hand in control group 10% patients had normal coronary artery disease, 40% had single vessel disease, 32% had double vessel disease and 18% had triple vessel disease. Conclusion: The study showed significant increase in number of coronary artery involvement by atherosclerotic lesions with increasing levels of plasma homocysteine level. Key words: Homocysteine; Coronary artery disease; Coronary angiogram. DOI: http://dx.doi.org/10.3329/cardio.v1i2.8124 Cardiovasc. j. 2009; 1(2) : 169-173

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