scholarly journals Association between Serum Inorganic Phosphorus Levels and Adverse Outcomes in Chronic Kidney Disease: The Fukushima CKD Cohort Study

2022 ◽  
Author(s):  
Akira Oda ◽  
Kenichi Tanaka ◽  
Hirotaka Saito ◽  
Tsuyoshi Iwasaki ◽  
Shuhei Watanabe ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Cohort Study ◽  
Kidney Disease ◽  
Inorganic Phosphorus ◽  
Adverse Outcomes ◽  
Phosphorus Levels

scholarly journals Association between serum phosphorus levels and adverse outcomes in chronic kidney disease: an observational cohort study

2021 ◽  
Author(s):  
Akira Oda ◽  
Kenichi Tanaka ◽  
Hirotaka Saito ◽  
Tsuyoshi Iwasaki ◽  
Shuhei Watanabe ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Cohort Study ◽  
Kidney Disease ◽  
Cardiovascular Events ◽  
Cox Regression ◽  
Hazard Ratio ◽  
Adverse Outcomes ◽  
Serum Phosphorus ◽  
Increased Risk ◽  
Phosphorus Levels

Abstract Background Although an association between serum phosphorus levels and poor prognosis has been noted in dialysis patients, these associations have been insufficiently reported in non-dialysis dependent chronic kidney disease (NDD-CKD) patients. This study attempted to determine the association between serum phosphorus levels and adverse outcomes in Japanese NDD-CKD patients. Methods We investigated the relationships between serum phosphorus levels and adverse outcomes such as kidney events, cardiovascular events, and all-cause death in Japanese NDD-CKD patients, using the longitudinal data of the Fukushima CKD Cohort Study. The study evaluated 822 patients with NDD-CKD enrolled between June 2012 and July 2014. A kidney event was defined as a combination of doubling of the baseline serum creatinine or end-stage renal disease. Cox regression was performed to analyze the relationships of the quartile of the serum phosphorus with kidney events, cardiovascular events, and all-cause death. Results Over a median follow-up period of 2.8 years, 46 patients died, there were 50 cardiovascular events, and 102 kidney events occurred. Increased risk of kidney events was observed in patients with higher serum phosphorus, with the lowest risk shown to be a second quartile of serum phosphorus level of 2.9–3.2 mg/dL. Multivariable Cox regression analysis showed an increased risk of kidney events for the highest quartile of the serum phosphorus levels (≥ 3.7 mg/dL) versus the second quartile (2.9–3.2 mg/dL, hazard ratio, 3.62; 95% confidence interval, 1.65–7.94; P = 0.001). A 1 mg/dL increase of the serum phosphorus was associated with an adjusted hazard ratio of 1.66 (95% CI; 1.24–2.20) for the kidney events. There were no significant associations between the serum phosphorus levels at baseline and the risk of cardiovascular events and all-cause death. Conclusions Serum phosphorus levels were associated with an increased risk of CKD progression in Japanese NDD-CKD patients.

Association between serum potassium levels and adverse outcomes in chronic kidney disease: the Fukushima CKD cohort study

2021 ◽  
Author(s):  
Kenichi Tanaka ◽  
Hirotaka Saito ◽  
Tsuyoshi Iwasaki ◽  
Akira Oda ◽  
Shuhei Watanabe ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Cohort Study ◽  
Kidney Disease ◽  
Serum Potassium ◽  
Adverse Outcomes

scholarly journals Association between non-malignant monoclonal gammopathy and adverse outcomes in chronic kidney disease: A cohort study

PLoS Medicine ◽  
2020 ◽  
Vol 17 (2) ◽  
pp. e1003050
Author(s):  
Anthony Fenton ◽  
Rajkumar Chinnadurai ◽  
Latha Gullapudi ◽  
Petros Kampanis ◽  
Indranil Dasgupta ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Cohort Study ◽  
Kidney Disease ◽  
Monoclonal Gammopathy ◽  
Adverse Outcomes

Adverse outcomes of proton pump inhibitors in patients with chronic kidney disease The CKD‐REIN cohort study

2020 ◽  
Author(s):  
Sophie Liabeuf ◽  
Oriane Lambert ◽  
Marie Metzger ◽  
Aghiles Hamroun ◽  
Maurice Laville ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Cohort Study ◽  
Kidney Disease ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Adverse Outcomes

scholarly journals Association of chronic kidney disease (CKD) and failure to monitor renal function with adverse outcomes in people with diabetes: a primary care cohort study

2013 ◽  
Vol 14 (1) ◽  
Author(s):  
Andrew P McGovern ◽  
Benjamin Rusholme ◽  
Simon Jones ◽  
Jeremy N van Vlymen ◽  
Harshana Liyanage ◽  
...  
Keyword(s):  
Primary Care ◽  
Chronic Kidney Disease ◽  
Renal Function ◽  
Cohort Study ◽  
Kidney Disease ◽  
Adverse Outcomes

scholarly journals Infection in Advanced Chronic Kidney Disease and Subsequent Adverse Outcomes after Dialysis Initiation: A Nationwide Cohort Study

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Chih-Hsiang Chang ◽  
Pei-Chun Fan ◽  
George Kuo ◽  
Yu-Sheng Lin ◽  
Tsung-Yu Tsai ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Cohort Study ◽  
Kidney Disease ◽  
Adverse Outcomes ◽  
Dialysis Initiation ◽  
Advanced Chronic Kidney Disease

scholarly journals Comparison of Outcomes of Chronic Kidney Disease Based on Etiology: A Prospective Cohort Study

2021 ◽  
Author(s):  
Hyunjin Ryu ◽  
Yeji Hong ◽  
Eunjeong Kang ◽  
Minjung Kang ◽  
Jayoun Kim ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Cohort Study ◽  
Kidney Disease ◽  
Kidney Failure ◽  
Adverse Outcomes ◽  
Hypertensive Nephropathy ◽  
Relative Risks ◽  
Hazard Ratios ◽  
Renal Progression ◽  
Egfr Decline

Abstract Background and objectivesThe cause of chronic kidney disease (CKD) affects outcomes. However, relative risks for adverse outcomes according to specific causes of CKD are not well studied.Design, setting, participants and measurementsProspective cohort study from KNOW-CKD cohort were analyzed using overlap propensity score weighting methods. Patients were grouped into four categories according to the cause of CKD: glomerulonephritis (GN), diabetic nephropathy (DN), hypertensive nephropathy (HTN), or polycystic kidney disease (PKD). From a total of 2,070 patients, the relative risk of kidney failure, composite of cardiovascular disease (CVD) and mortality, and the slope of the estimated glomerular filtration rate (eGFR) decline according to the cause of CKD were compared between causative groups pairwisely.ResultsThere were 565 cases of kidney failure and 259 cases of composite CVD and death over 6.0 years of follow-up. Hazard ratios of the PKD group for kidney failure were significantly increased at 1.82, 2.23, and 1.73 compared to GN, HTN, and DN, respectively. Hazard ratios of the DN group for the composite of CVD and death were also significantly increased at 2.07, and 1.73 compared to GN, and HTN, respectively. The adjusted eGFR decline slope for DN and PKD groups was -3.07, and -3.37 mL/min/1.73m2 per year, respectively, and all of these values were significantly different than those of the GN and HTN groups (-2.16, and -1.42 mL/min/1.73m2 per year, respectively).ConclusionsRisks for renal progression were relatively higher in patients with PKD compared to other causes of CKD. However, the composite of CVD and death were relatively higher in patients with DN-related CKD than those with GN- and HTN-related CKD.

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