scholarly journals A HYPERCALCEMIC CRISIS FOLLOWING ABRUPT DISCONTINUATION OF LONG TERM ADRENAL STEROID THERAPY

1968 ◽  
Vol 57 (1) ◽  
pp. 105-112
Author(s):  
Yotaro HURUKAWA ◽  
Chikashi SASAKI ◽  
Toshio OTOMO ◽  
Tsutomu TAKAWA ◽  
Isao Miwa ◽  
...  
Keyword(s):  
Steroid Therapy ◽  
Adrenal Steroid ◽  
Hypercalcemic Crisis ◽  
Abrupt Discontinuation

THE EXCRETION OF URINARY 11-OXY- AND 11-DEOXY-17-HYDROXYCORTICOSTEROIDS DURING THE ADMINISTRATION OF ACTH AND METYRAPONE IN PATIENTS GIVEN LONG-TERM ADRENAL STEROID THERAPY

1967 ◽  
Vol 56 (1_Suppl) ◽  
pp. S40
Author(s):  
Theodor Jakobson ◽  
Leif Strandström ◽  
Marja-Liisa Kotovirta ◽  
Marcus Sundberg
Keyword(s):  
Steroid Therapy ◽  
Adrenal Steroid

PITUITARY-ADRENAL FUNCTION IN PATIENTS GIVEN LONG-TERM ADRENAL STEROID THERAPY

1968 ◽  
Vol 59 (1) ◽  
pp. 76-88 ◽  
Author(s):  
Theodor Jakobson ◽  
Marcus Sundberg ◽  
Marja-Liisa Kotovirta ◽  
Leif Strandström
Keyword(s):  
Rheumatoid Arthritis ◽  
Total Dose ◽  
Bronchial Asthma ◽  
Steroid Therapy ◽  
Adrenal Function ◽  
Continuous Treatment ◽  
Adrenal Steroid ◽  
Adrenocortical Response ◽  
Adrenal Response

ABSTRACT Pituitary-adrenal function was investigated in 23 patients with rheumatoid arthritis and in 19 patients with bronchial asthma following prolonged glucocorticoid therapy. The duration of continuous treatment varied from 2 months to 15 years and the total dose of steroids from 400 mg to 54 g of prednisolone or its equivalent. After treatment had been discontinued, pituitary ACTH-reserve was estimated by means of an oral metyrapone test and adrenal response to ACTH by means of an intravenous or intramuscular ACTH-test. The pituitary ACTH-response was evaluated by determining the increment in the excretion of 11-deoxy-17-hydroxycorticosteroids during the administration of the metyrapone blocking agent and adrenal response to ACTH by the excretion of 11-oxygenated corticosteroids. The reduction of the metyrapone and ACTH responses were found to be related to the duration of prednisolone treatment as well as to the daily and total administered dose, although a marked individual variation in several instances could be observed in the degree of suppression of endogenous ACTH or corticosteroid production. Deficient metyrapone and ACTH responses were more frequently encountered in bronchial asthma than in patients with rheumatoid arthritis who had received comparable doses of glucocorticoids during similar periods. No negative metyrapone tests, however, in either group of patients were obtained for 12 months or unless the total dose of steroids administered was at least 3.5 g of prednisolone or its equivalent. Most patients who showed reduced adrenocortical response to ACTH had received large total doses of corticosteroids and the lowest total dose on which a subnormal ACTH-response was observed was 6 g. The results demonstrate that both pituitary ACTH-reserve and adrenocortical response to ACTH can be reduced by long-term adrenal steroid therapy, although the loss of pituitary ACTH-response occurs earlier during the course of treatment.

scholarly journals Severe Posaconazole-Induced Glucocorticoid Deficiency with Concurrent Pseudohyperaldosteronism: An Unfortunate Two-for-One Special

2021 ◽  
Vol 7 (8) ◽  
pp. 620
Author(s):  
Alejandro Villar-Prados ◽  
Julia J. Chang ◽  
David A. Stevens ◽  
Gary K. Schoolnik ◽  
Samantha X. Y. Wang
Keyword(s):  
Mechanism Of Action ◽  
Antifungal Agents ◽  
Laboratory Findings ◽  
Steroid Synthesis ◽  
Adrenal Steroid ◽  
History Of ◽  
Glucocorticoid Deficiency

A 56-year-old Hispanic man with a history of disseminated coccidioidomycosis was diagnosed with persistent glucocorticoid insufficiency and pseudohyperaldosteronism secondary to posaconazole toxicity. This case was notable for unexpected laboratory findings of both pseudohyperaldosteronism and severe glucocorticoid deficiency due to posaconazole’s mechanism of action on the adrenal steroid synthesis pathway. Transitioning to fluconazole and starting hydrocortisone resolved the hypokalemia but not his glucocorticoid deficiency. This case highlights the importance of recognizing iatrogenic glucocorticoid deficiency with azole antifungal agents and potential long term sequalae.

Adrenal and Pituitary Functions during Long-Term Topical Steroid Therapy

Dermatology ◽  
1972 ◽  
Vol 144 (3) ◽  
pp. 179-186 ◽  
Author(s):  
J.C.M. Hendrikse ◽  
A.J. Moolenaar
Keyword(s):  
Steroid Therapy ◽  
Topical Steroid ◽  
Topical Steroid Therapy

Long-term preserved renal function of a patient with mass-forming granulomatous interstitial nephritis by biopsy-based steroid therapy

2010 ◽  
Vol 14 (6) ◽  
pp. 625-629 ◽  
Author(s):  
Junji Yamauchi ◽  
Yoshifumi Ubara ◽  
Tatsuya Suwabe ◽  
Masayuki Yamanouchi ◽  
Noriko Hayami ◽  
...  
Keyword(s):  
Renal Function ◽  
Interstitial Nephritis ◽  
Steroid Therapy ◽  
Granulomatous Interstitial Nephritis

ESTIMATION OF SEVERITY OF THE NEPHROTIC SYNDROME IN CHILDHOOD AS A GUIDE TO THERAPY AND PROGNOSIS

PEDIATRICS ◽  
1959 ◽  
Vol 23 (5) ◽  
pp. 861-873
Author(s):  
W. W. McCrory ◽  
M. Rapoport ◽  
D. S. Fleisher
Keyword(s):  
Nephrotic Syndrome ◽  
Hormone Therapy ◽  
Small Group ◽  
Clinical Response ◽  
Steroid Therapy ◽  
Prognostic Value ◽  
Therapeutic Benefits ◽  
Adrenocortical Hormone ◽  
Glomerular Damage

The degree of clinical and biochemical improvement observed in 20 children with the nephrotic syndrome who received a similar course of adrenocortical steroid therapy has been correlated with the severity of the existing renal glomerular damage. It appears that the clinical response of children with nephrosis to hormone therapy and their behavior shortly thereafter can provide the physician with information of prognostic value at an earlier period in the course of the disease than has been possible heretofore. This was especially true in the case of patients destined to have a favorable outcome. The immediate and long-term therapeutic benefits obtained in a small group of patients with nephrosis, who received sufficient adrenocortical hormone therapy to induce and maintain maximal improvement in all measurable abnormalities, are superior to the results obtained by therapy aimed only at control of edema.

scholarly journals A Case of a Ventral Hernia due to Rupture of the Abdominal Wall Muscle in a Patient with SLE on Long-term Steroid Therapy

2015 ◽  
Vol 76 (3) ◽  
pp. 626-630
Author(s):  
Masahiro FUKADA ◽  
Nobuhisa MATSUHASHI ◽  
Takao TAKAHASHI ◽  
Kazuya YAMAGUCHI ◽  
Shinji OSADA ◽  
...  
Keyword(s):  
Abdominal Wall ◽  
Ventral Hernia ◽  
Steroid Therapy ◽  
Abdominal Wall Muscle
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