Recently, a model for colorful black hole production and decay in proton–proton collisions has been constructed. These results can be extended to a multiverse, because it is obvious that there is enough energy in cosmic rays to produce a baby Universe. It is observed that these Universes are defined by their gauge charges. Notably, Universes can have a color charge. This is not in contradiction with confinement because the typical length scale of QCD (i.e., a Fermi) is much larger than the size of a baby Universe at its birth. These colorful Universes can interact with each other, annihilate, and form a color singlet Universe. Next, it is argued that color confinement may generate an entanglement between colorful dark energy Universes to form a color singlet binary system. Finally, the production cross section for entangled colorful dark energy Universes in a multiverse is obtained. It is found that the cross section of a Friedmann–Robertson–Walker Universe is much larger for smaller values of the Hubble parameter. Also, this cross section is greater for entangled open Universes and smaller for entangled closed Universes.