scholarly journals Task Parallelism to Optimize Performance of Environmental Modeling Software

2021 ◽  
Author(s):  
Althea Denlinger
Keyword(s):  
Environmental Modeling ◽  
Task Parallelism ◽  
Modeling Software

Biodegradable 3D Printed Polymer Microneedles for Transdermal Drug Delivery

2018 ◽  
Author(s):  
Michael A. Luzuriaga ◽  
Danielle R. Berry ◽  
John C. Reagan ◽  
Ronald A. Smaldone ◽  
Jeremiah J. Gassensmith
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Transdermal Drug Delivery ◽  
Fused Deposition Modeling ◽  
Fused Deposition ◽  
Modeling Software ◽  
Deposition Modeling ◽  
3D Printed ◽  
Microfabrication Technique ◽  
Mechanical Strengths

Biodegradable polymer microneedle (MN) arrays are an emerging class of transdermal drug delivery devices that promise a painless and sanitary alternative to syringes; however, prototyping bespoke needle architectures is expensive and requires production of new master templates. Here, we present a new microfabrication technique for MNs using fused deposition modeling (FDM) 3D printing using polylactic acid, an FDA approved, renewable, biodegradable, thermoplastic material. We show how this natural degradability can be exploited to overcome a key challenge of FDM 3D printing, in particular the low resolution of these printers. We improved the feature size of the printed parts significantly by developing a post fabrication chemical etching protocol, which allowed us to access tip sizes as small as 1 μm. With 3D modeling software, various MN shapes were designed and printed rapidly with custom needle density, length, and shape. Scanning electron microscopy confirmed that our method resulted in needle tip sizes in the range of 1 – 55 µm, which could successfully penetrate and break off into porcine skin. We have also shown that these MNs have comparable mechanical strengths to currently fabricated MNs and we further demonstrated how the swellability of PLA can be exploited to load small molecule drugs and how its degradability in skin can release those small molecules over time.

Development of Multi-Scale Modeling Software for Entangled Soft Matter in Advanced Soldier Protection

2011 ◽  
Author(s):  
Jay D. Schieber ◽  
David Venerus ◽  
H. L. Scott
Keyword(s):  
Soft Matter ◽  
Multi Scale ◽  
Scale Modeling ◽  
Modeling Software ◽  
Multi Scale Modeling

Environmental Modeling and Simulation

1977 ◽  
Vol 41 (2) ◽  
pp. vi-vi
Author(s):  
M. H. Frere
Keyword(s):  
Modeling And Simulation ◽  
Environmental Modeling

A CONVERSION TOOL FOR OUTPUTS OF STANFORD GEOSTATISTICAL MODELING SOFTWARE TO ARCGIS

2020 ◽  
Author(s):  
Kristofer Veselits ◽  
◽  
Joshua Coyan
Keyword(s):  
Geostatistical Modeling ◽  
Modeling Software ◽  
Conversion Tool

Microstructures in Elastic Media

1994 ◽  
Author(s):  
Nhan Phan-Thien ◽  
Sangtae Kim
Keyword(s):  
Computational Methods ◽  
High Performance ◽  
Chemical Engineering ◽  
Elliptic Partial Differential Equations ◽  
Parallel Computers ◽  
Computational Algorithms ◽  
Applied Physics ◽  
Advanced Students ◽  
Particulate Solids ◽  
Modeling Software

This monograph describes various methods for solving deformation problems of particulate solids, taking the reader from analytical to computational methods. The book is the first to present the topic of linear elasticity in mathematical terms that will be familiar to anyone with a grounding in fluid mechanics. It incorporates the latest advances in computational algorithms for elliptic partial differential equations, and provides the groundwork for simulations on high performance parallel computers. Numerous exercises complement the theoretical discussions, and a related set of self-documented programs is available to readers with Internet access. The work will be of interest to advanced students and practicing researchers in mechanical engineering, chemical engineering, applied physics, computational methods, and developers of numerical modeling software.

Application of Expert Systems Technology in Water Quality Modeling

1989 ◽  
Vol 21 (8-9) ◽  
pp. 1045-1056 ◽  
Author(s):  
Thomas O. Barnwell ◽  
Linfield C. Brown ◽  
Wiktor Marek
Keyword(s):  
Water Quality ◽  
Expert Systems ◽  
Knowledge Engineering ◽  
Stream Water ◽  
Environmental Modeling ◽  
Water Quality Modeling ◽  
Stream Water Quality ◽  
Quality Model ◽  
Knowledge Based ◽  
Available Technology

Computerized modeling is becoming an integral part of decision making in water pollution control. Expert systems is an innovative methodology that can assist in building, using, and interpreting the output of these models. This paper reviews the use and evaluates the potential of expert systems technology in environmental modeling and describes elements of an expert advisor for the stream water quality model QUAL2E. Some general conclusions are presented about the tools available to develop this system, the level of available technology in knowledge-based engineering, and the value of approaching problems from a knowledge engineering perspective.

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