scholarly journals THE STUDY OF MENSTRUAL AND OTHER BLOOD LOSS, AND CONSEQUENT IRON DEFICIENCY BY Fe$sup 59$ WHOLE BODY COUNTING

1962 ◽  
Author(s):  
D.C. Price ◽  
E.M. Forsyth ◽  
S.H. Cohn ◽  
E.P. Cronkite
1975 ◽  
Vol 14 (01) ◽  
pp. 74-80
Author(s):  
M. M. Gupta ◽  
R. Manchanda ◽  
L. Bhattacharyya ◽  
M. Bhargva ◽  
S. Kumar ◽  
...  

SummaryA preliminary study of iron absorption by whole body counting was carried on a group of 16 women. The cases included 8 patients suffering from iron deficiency anaemia and various infections as well as 8 healthy controls. High iron absorption is associated with iron dificiency, these changes being more marked in iron deficient controls than in those with infection or malignancy. In iron deficient controls results of whole body counting correlate very well with other haematological investigations.


Blood ◽  
1962 ◽  
Vol 20 (5) ◽  
pp. 517-531 ◽  
Author(s):  
D. C. PRICE ◽  
S. H. COHN ◽  
L. R. WASSERMAN ◽  
P. G. REIZENSTEIN ◽  
EUGENE P. CRONKITE

Abstract A technic for the study of radioiron absorption and loss is described employing an NaI (T1) crystal-detector whole body counter and 1-10 µc. Fe59 in 250 µg. elemental iron. Changes in whole body Fe59 activity during the first few hours and the next 90-100 days after oral ingestion are described and their significance discussed. Normal absorption with this technic ranges from 5.7-24.7 per cent of the administered tracer. In 14 patients with polycythemia vera, 12 previously phlebotomized and 2 with a recent history of gastrointestinal hemorrhage, iron deficiency as evidenced by increased iron absorption (20.6 per cent-96.9 per cent) correlates well with the extent of preceding phlebotomy, and relatively well with the plasma iron at the time of study. Although other parameters reflect iron deficiency, none correlate well with the absorption of radioiron. Next to increased iron absorption, depletion of iron stores in the marrow seems to be the earliest evidence of iron deficiency. Iron absorption and erythrocyte incorporation of radioiron was also studied in several other hematologic disorders, including four heavily menstruating women, three cases of aplastic anemia, and a small number of other conditions. The findings are described and discussed. Radioiron loss in three normal patients was 0.110 per cent, 0.110 per cent, and 0.182 per cent daily, and in two patients with aplastic anemia 0.103 per cent and 0.173 per cent daily, defining the normal range of tracer loss over days 20-100. Radioiron loss in the polycythemics ranged from 0-0.044 per cent daily. An unusual case of pyridoxine-responsive anemia with increased absorption of radioiron (69.1 per cent), but no red cell incorporation, lost only 0.026 per cent/day. Some problems in the interpretation of such data are discussed. The results demonstrate the effectiveness of the technic of whole body counting in the study of various aspects of iron metabolism.


1977 ◽  
Vol 16 (04) ◽  
pp. 163-167
Author(s):  
K. Bakos ◽  
Věra Wernischová

SummaryWhole-body counting makes an important contribution of radioisotope techniques to ȁEin vivo“ absorption studies, in comparison with other methods. In a large number of subjects, the method was tested for its usefulness in the diagnosis of calcium malabsorption. The effects of drugs, of the calcium load in the gut and of the whole-body content of calcium on the absorption process were studied in a control group.


1976 ◽  
Vol 15 (05) ◽  
pp. 246-247
Author(s):  
S. C. Jain ◽  
G. C. Bhola ◽  
A. Nagaratnam ◽  
M. M. Gupta

SummaryIn the Marinelli chair, a geometry widely used in whole body counting, the lower part of the leg is seen quite inefficiently by the detector. The present paper describes an attempt to modify the standard chair geometry to minimise this limitation. The subject sits crossed-legged in the “Buddha Posture” in the standard chair. Studies with humanoid phantoms and a volunteer sitting in the Buddha posture show that this modification brings marked improvement over the Marinelli chair both from the point of view of sensitivity and uniformity of spatial response.


1984 ◽  
Vol 246 (2) ◽  
pp. F234-F239 ◽  
Author(s):  
R. N. Pierson ◽  
J. Wang ◽  
J. C. Thornton ◽  
T. B. Van Itallie ◽  
E. W. Colt

Four-pi whole body counting for the 1.46 meV photon of 40K has apparent advantages over single-crystal or two-pi counters in efficiency and in subject geometry independence. However, our studies of obese populations have disclosed a systematic undermeasurement of 40K, suggesting that nonhomogeneous K distribution results in systematic undercounting of 40K. In the current study 42K, emitting a 1.52 meV photon, was used in 109 volunteers ranging from 50 to 181 kg, and multiregression covariance analysis was applied to develop correction formulas based on anthropometrics. These corrections quantitatively account for the unappreciated loss of 40K and 42K photons in annular adipose tissue that surrounds the lean body, in which most K+ is concentrated. The correction ranges from 1 to 28% and is a linear (although different) function of weight in both sexes. Thus corrected, body potassium measurements, taken in conjunction with exchangeable sodium and water measurements, provide estimates for whole body osmolality that match measured serum values. Such a quantitative accounting for previously "lost" cation in 58 subjects provides independent evidence for the appropriateness and accuracy of the correction. With this correction, body potassium was recalculated in the 1,492 adult members of a previously reported group of 3,083 subjects.


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