Bioactive Hydrogel Scaffolds - Advances in Cartilage Regeneration Through Controlled Drug Delivery

Scaffolds are used for drug delivery in tissue engineering as this system is a highly porous structure to allow tissue growth. Although several tissues in the body can regenerate, other tissue such as heart muscles and nerves lack regeneration in adults. However, these can be regenerated by supplying the cells generated using tissue engineering from outside. For instance, in many heart diseases, there is need for heart valve transplantation and unfortunately, within 10 years of initial valve replacement, 50–60% of patients will experience prosthesis associated problems requiring reoperation. This could be avoided by transplantation of heart muscle cells that can regenerate. Delivery of these cells to the respective tissues is not an easy task and this could be done with the help of scaffolds. In situ gel forming scaffolds can also be used for the bone and cartilage regeneration. They can be injected anywhere and can take the shape of a tissue defect, avoiding the need for patient specific scaffold prefabrication and they also have other advantages. Scaffolds are prepared by biodegradable material that result in minimal immune and inflammatory response. Some of the very important issues regarding scaffolds as drug delivery systems is reviewed in this article.

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Injectable Absorbable Ocular Inserts for Controlled Drug Delivery

10.21236/adb229497 ◽

1997 ◽

Cited By ~ 1

Author(s):

Shalaby W. Shalaby

Keyword(s):

Drug Delivery ◽

Controlled Drug Delivery

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Methods for Synthesizing the Macromolecular Constituents of Smart Nanosized Carriers for Controlled Drug Delivery

Current Medicinal Chemistry ◽

10.2174/0929867321666140304103437 ◽

2014 ◽

Vol 21 (29) ◽

pp. 3333-3374 ◽

Cited By ~ 5

Author(s):

Paul Balaure ◽

Alexandru Grumezescu

Keyword(s):

Drug Delivery ◽

Controlled Drug Delivery

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Atherosclerosis and Nanomedicine Potential: Current Advances and Future Opportunities

Current Medicinal Chemistry ◽

10.2174/0929867326666190301143952 ◽

2020 ◽

Vol 27 (21) ◽

pp. 3534-3554 ◽

Cited By ~ 2

Author(s):

Fan Jiang ◽

Yunqi Zhu ◽

Changyang Gong ◽

Xin Wei

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Controlled Drug Delivery ◽

Vascular Wall ◽

Arterial Disease ◽

Diagnosis And Treatment ◽

Antiinflammatory Therapy ◽

Limited Efficacy ◽

Conventional Drug ◽

Diagnostic Modalities

Atherosclerosis is the leading inducement of cardiovascular diseases, which ranks the first cause of global deaths. It is an arterial disease associated with dyslipidemia and changes in the composition of the vascular wall. Besides invasive surgical strategy, the current conservative clinical treatment for atherosclerosis falls into two categories, lipid regulating-based therapy and antiinflammatory therapy. However, the existing strategies based on conventional drug delivery systems have shown limited efficacy against disease development and plenty of side effects. Nanomedicine has great potential in the development of targeted therapy, controlled drug delivery and release, the design of novel specific drugs and diagnostic modalities, and biocompatible scaffolds with multifunctional characteristics, which has led to an evolution in the diagnosis and treatment of atherosclerosis. This paper will focus on the latest nanomedicine strategies for atherosclerosis diagnosis and treatment as well as discussing the potential therapeutic targets during atherosclerosis progress, which could form the basis of development of novel nanoplatform against atherosclerosis.

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