The Role of Chinese Herbal Medicines and Bioactive Ingredients Targeting Myocardial KCa and KATP Channels in Cardiovascular Diseases

2017 ◽  
Vol 23 (7) ◽  
pp. 1070-1076 ◽  
Author(s):  
Yan Dong ◽  
Pengqian Wang ◽  
Xue Feng ◽  
Bing Li ◽  
Zhong Wang ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Herbal Medicines ◽  
Katp Channels ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal ◽  
Bioactive Ingredients

Neuraminidase 1 and its Inhibitors from Chinese Herbal Medicines: An Emerging Role for Cardiovascular Diseases

2021 ◽  
pp. 1-20
Author(s):  
Jun-Yuan Zhang ◽  
Qian-Qian Chen ◽  
Jia Li ◽  
Lei Zhang ◽  
Lian-Wen Qi
Keyword(s):  
Sialic Acid ◽  
Cardiovascular Diseases ◽  
Chinese Herb ◽  
Herbal Medicines ◽  
Chinese Herbs ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal ◽  
Scutellariae Radix ◽  
Cytoplasmic Vesicles

Neuraminidase, also known as sialidase, is ubiquitous in animals and microorganisms. It is predominantly distributed in the cell membrane, cytoplasmic vesicles, and lysosomes. Neuraminidase generally recognizes the sialic acid glycosidic bonds at the ends of glycoproteins or glycolipids and enzymatically removes sialic acid. There are four types of neuraminidases, named as Neu1, Neu2, Neu3, and Neu4. Among them, Neu1 is the most abundant in mammals. Recent studies have revealed the involvement of Neu1 in several diseases, including cardiovascular diseases, diabetes, cancers, and neurological disorders. In this review, we center the attention to the role of Neu1 in cardiovascular diseases, including atherosclerosis, ischemic myocardial injury, cerebrovascular disease, congenital heart disease, and pulmonary embolism. We also summarize inhibitors from Chinese herbal medicines (CHMs) in inhibiting virus neuraminidase or human Neu1. Many Chinese herbs and Chinese herb preparations, such as Lonicerae Japonicae Flos, Scutellariae Radix, Yupingfeng San, and Huanglian Jiedu Decoction, have neuraminidase inhibitory activity. We hope to highlight the emerging role of Neu1 in humans and potentially titillate interest for further studies in this area.

scholarly journals Role of MicroRNAs Induced by Chinese Herbal Medicines Against Hepatocellular Carcinoma: A Brief Review

2018 ◽  
Vol 17 (4) ◽  
pp. 1059-1067 ◽  
Author(s):  
Ge Guo ◽  
Juhua Zhou ◽  
Xiaogaung Yang ◽  
Jiang Feng ◽  
Yanxia Shao ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Small Rnas ◽  
Herbal Medicines ◽  
Early Embryo ◽  
Invasion And Metastasis ◽  
Chinese Herbal Medicines ◽  
Regulate Gene Expression ◽  
Early Embryo Development ◽  
Chinese Herbal

MicroRNAs (miRNAs) are highly conserved, noncoding small RNAs that regulate gene expression, and consequently several important functions including early embryo development, cell cycle, programmed cell death, cell differentiation, and metabolism. While there are no effective treatments available against hepatocellular carcinoma (HCC), some Chinese herbal medicines have been shown to regulate growth, differentiation, invasion, and metastasis of HCC. Many studies have shown that Chinese herbal medicines regulate the expression of miRNAs and this may be associated with their ability to control the development of HCC. In this article, the effects of Chinese herbal medicines on the expression of miRNAs and their functions in the regulation of HCC have been reviewed and discussed. miRNAs such as miRNA-221 and miRNA-222 mediated by Chinese herbal medicines may be good biomarkers and therapeutic targets for HCC.

The role of Chinese herbal medicines in a rat model of chronic colitis

2000 ◽  
Vol 118 (4) ◽  
pp. A1372 ◽  
Author(s):  
Xiaolan Tian ◽  
Marisabel Mourelle ◽  
Yuling Li ◽  
Francisco Guarner ◽  
Juan-R Malagelada
Keyword(s):  
Rat Model ◽  
Herbal Medicines ◽  
Chronic Colitis ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal
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