A Glassy Carbon Electrode for The Determination of Linagliptin Antidiabetic Drug in Pure, tablets and some biological fluids by Adsorptive Stripping Voltammetry

2020 ◽  
Vol 26 ◽  
Author(s):  
Ahmed A Gahlan ◽  
Ahmed M Haredy ◽  
Sayed M Derayea ◽  
Mahmoud A Omar ◽  
Gamal A Saleh
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Biological Fluids ◽  
Stripping Voltammetry ◽  
Carbon Electrode ◽  
Antidiabetic Drug ◽  
Quantitation Limit ◽  
Pharmaceutical Form ◽  
Voltammetric Technique

Aim: The present work provides a fast, simple, accurate, and inexpensive analytical method for the determination of Linagliptin (anti-diabetic drug). Methods: Using a square wave adsorptive anodic stripping voltammetric technique (SWAASV) and glassy carbon electrode (GCE) as a working electrode. The experimental and instrumental parameters were studied and discussed to ensure the validity of the method. Results: The method has a very good linearity (R2 = 0.9984), wide concentration range (0.189 - 2.268) µg mL -1 ), low detection limit 0.052 µg mL -1 and low quantitation limit 0.172 µg mL -1 . Conclusion: Linagliptin was determined successfully in pharmaceutical form, spiked urine and plasma with 99.67, 91.96, and 92.78 % recovery respectively by using the proposed method, and the results obtained were compared with other reported methods.

scholarly journals The effect of tamoxifen on the electrochemical behavior of Bi+3/Bi on the glassy carbon electrode and its determination via differential pulse anodic stripping voltammetry

2019 ◽  
Vol 63 (1) ◽  
Author(s):  
Mehdi Jalali ◽  
Zeinab Deris Falahieh ◽  
Mohammad Alimoradi ◽  
Jalal Albadi ◽  
Ali Niazi
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Electrochemical Behavior ◽  
Electrochemical Impedance ◽  
Anodic Stripping Voltammetry ◽  
Stripping Voltammetry ◽  
Differential Pulse ◽  
Peak Height ◽  
Carbon Electrode

The electrochemical behavior of Bi+3 ions on the surface of a glassy carbon electrode, in acidic media and in the presence of tamoxifen, was investigated. Cyclic voltammetry, chronoamperometry, differential pulse voltammetry, electrochemical impedance spectroscopy, and scanning electron microscopy with energy-dispersive X-ray spectroscopy were used to find the probable mechanism contributing to the reduction of the peak height of bismuth oxidation with an increase in the concentration of tamoxifen. The obtained results show a slight interaction between the bismuth species and tamoxifen which co-deposit on the surface of glassy carbon electrode. Therefore, the reduction in the peak height of bismuth oxidation as a function of tamoxifen concentration was used to develop a new differential pulse anodic striping voltammetry method for determination of trace amount of tamoxifen. The effects of experimental parameters on the in situ DPASV of Bi+3 ions in the presence of tamoxifen shown the optimal conditions as: 2 mol L-1 H2SO4 (1% v v-1 MeOH), a deposition potential of -0.5 V, a deposition time of 60 s, and a glassy carbon electrode rotation rate of 300 rpm. The calibration curve was plotted in the range of 0.5 to 6 µg mL-1 and the limits of detection and quantitation were calculated to be 3.1 × 10-5 µg mL-1 and 1.0 × 10-4 µg mL-1, respectively. The mean, RSD, and relative bias for 0.5 µg mL-1 (n=5) were found to be 0.49 µg mL-1, 0.3%, and 2%, respectively. Finally, the proposed method was successfully used for the determination of tamoxifen in serum and pharmaceutical samples.

Ultra-Sensitive Anodic Stripping Voltammetry for the Determination of Xanthine at a Glassy Carbon Electrode

2004 ◽  
Vol 144 (4) ◽  
pp. 249-256 ◽  
Author(s):  
Mohamed S. Ibrahim ◽  
Yassien M. Temerk ◽  
Moustafa M. Kamal ◽  
Gamal A.-W. Ahmed ◽  
Hossieny S. M. Ibrahim
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Anodic Stripping Voltammetry ◽  
Stripping Voltammetry ◽  
Carbon Electrode ◽  
Anodic Stripping

Determination of enzyme activity in biological fluids by means of electrochemical oxidation of NADH at a modified glassy carbon electrode.

1984 ◽  
Vol 30 (11) ◽  
pp. 1780-1783 ◽  
Author(s):  
L Bartalits ◽  
G Nagy ◽  
E Pungor
Keyword(s):  
Enzyme Activity ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Biological Fluids ◽  
Enzyme Reaction ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Significant Difference ◽  
Anodic Peak Current

Abstract This amperometric technique for the determination of enzyme activity is based on detecting a decrease in the concentration of the NADH co-factor of the enzyme reaction. A glassy carbon electrode, modified by adsorption of Mg2+ and NADH, is used to measure the anodic peak current that corresponds to the oxidation of NADH. We found no significant difference between the enzyme activity of lactate dehydrogenase (E.C.1.1.1.27) preparations as measured by the above amperometric technique and by a spectrophotometric method.

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