GRASP55: A Multifunctional Protein

2020 ◽  
Vol 21 (6) ◽  
pp. 544-552 ◽  
Author(s):  
Hongrong Wu ◽  
Tianjiao Li ◽  
Jianfeng Zhao
Keyword(s):  
Crucial Role ◽  
Protein Modification ◽  
Secretory Pathway ◽  
Cell Activity ◽  
Vesicular Trafficking ◽  
Multifunctional Protein ◽  
Autophagosome Maturation

GRASP55 was first found as Golgi cisternae stacking protein. Due to the crucial role of Golgi in vesicular trafficking and protein modification, GRASP55 was found to function in these two aspects. Further investigation revealed that GRASP55 also participates in the unconventional secretory pathway under stress. Moreover, GRASP55 is involved in autophagy initiation and autophagosome maturation, as well as cell activity.

scholarly journals ER exit pathways and the control of proteostasis: Crucial role of the UPR, COPII, and ER-phagy in the secretory pathway

BIOCELL ◽  
2022 ◽  
Vol 46 (5) ◽  
pp. 1131-1137
Author(s):  
GIUSEPPINA AMODIO ◽  
VALENTINA PAGLIARA ◽  
PAOLO REMONDELLI ◽  
ORNELLA MOLTEDO
Keyword(s):  
Crucial Role ◽  
Secretory Pathway

scholarly journals Getting Sugar Coating Right! The Role of the Golgi Trafficking Machinery in Glycosylation

Cells ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 3275
Author(s):  
Zinia D’Souza ◽  
Farhana Taher Sumya ◽  
Amrita Khakurel ◽  
Vladimir Lupashin
Keyword(s):  
Ion Channels ◽  
Secretory Pathway ◽  
Small Gtpases ◽  
Vesicular Trafficking ◽  
Congenital Disorders ◽  
Congenital Disorders Of Glycosylation ◽  
Sugar Transporters ◽  
Vesicle Tethering ◽  
Independent Process

The Golgi is the central organelle of the secretory pathway and it houses the majority of the glycosylation machinery, which includes glycosylation enzymes and sugar transporters. Correct compartmentalization of the glycosylation machinery is achieved by retrograde vesicular trafficking as the secretory cargo moves forward by cisternal maturation. The vesicular trafficking machinery which includes vesicular coats, small GTPases, tethers and SNAREs, play a major role in coordinating the Golgi trafficking thereby achieving Golgi homeostasis. Glycosylation is a template-independent process, so its fidelity heavily relies on appropriate localization of the glycosylation machinery and Golgi homeostasis. Mutations in the glycosylation enzymes, sugar transporters, Golgi ion channels and several vesicle tethering factors cause congenital disorders of glycosylation (CDG) which encompass a group of multisystem disorders with varying severities. Here, we focus on the Golgi vesicle tethering and fusion machinery, namely, multisubunit tethering complexes and SNAREs and their role in Golgi trafficking and glycosylation. This review is a comprehensive summary of all the identified CDG causing mutations of the Golgi trafficking machinery in humans.

scholarly journals Role of Glycoproteins during Fruit Ripening and Seed Development

Cells ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 2095
Author(s):  
Angela Mendez-Yañez ◽  
Patricio Ramos ◽  
Luis Morales-Quintana
Keyword(s):  
Posttranslational Modifications ◽  
Fruit Ripening ◽  
Posttranslational Modification ◽  
Protein Modification ◽  
Secretory Pathway ◽  
Plant Cells ◽  
Protein Glycosylation ◽  
Cellular Processes ◽  
Fruit Development And Ripening

Approximately thirty percent of the proteins synthesized in animal or plant cells travel through the secretory pathway. Seventy to eighty percent of those proteins are glycosylated. Thus, glycosylation is an important protein modification that is related to many cellular processes, such as differentiation, recognition, development, signal transduction, and immune response. Additionally, glycosylation affects protein folding, solubility, stability, biogenesis, and activity. Specifically, in plants, glycosylation has recently been related to the fruit ripening process. This review aims to provide valuable information and discuss the available literature focused on three principal topics: (I) glycosylations as a key posttranslational modification in development in plants, (II) experimental and bioinformatics tools to analyze glycosylations, and (III) a literature review related to glycosylations in fruit ripening. Based on these three topics, we propose that it is necessary to increase the number of studies related to posttranslational modifications, specifically protein glycosylation because the specific role of glycosylation in the posttranslational process and how this process affects normal fruit development and ripening remain unclear to date.

Epitaxial YBa2Cu3O7-8 films : Crucial role of growth-induced linear defects in microwave properties

2001 ◽  
Vol 11 (PR11) ◽  
pp. Pr11-47-Pr11-52
Author(s):  
V. M. Pan ◽  
V. S. Flis ◽  
V. A. Komashko ◽  
O. G. Plys ◽  
C. G. Tretiatchenko ◽  
...  
Keyword(s):  
Crucial Role ◽  
Microwave Properties ◽  
Linear Defects

ANALISIS YURIDIS PUTUSAN PENGADILAN NEGERI BLORA TENTANG DUALISME KEPENGURUSAN YAYASAN PENDIDIKAN ISLAM KARTAYUDA YANG AKTA PENDIRIANNYA DIBUAT OLEH DAN DIHADAPAN NOTARIS (Studi Kasus Putusan Perkara PN Blora No. 34/Pdt.G/2015/PN.Bla)

Jurnal Akta ◽  
2017 ◽  
Vol 4 (3) ◽  
pp. 463
Author(s):  
Muslim Ansori ◽  
Akhmad Khisni
Keyword(s):  
Private Schools ◽  
Education System ◽  
Crucial Role ◽  
The State ◽  
Educational Institutions ◽  
Legal Entity ◽  
Non Profit ◽  
The Right

With the enactment of the Education System Act no 20 of 2003 (better known as the Sisdiknas Act), the State has determined that educational institutions should have a legal umbrella in the form of a legal entity, or better known as the Legal Entity Education. As a non-profit organization, the Foundation is the right legal entity that becomes a place for educational institutions, especially private schools. Therefore, of course, Notary has a very crucial role in making notary deed in the form of establishment and deed of change, such as example how in making the right basic budget and not multi interpresatasi for stake holders in the foundation. Therefore, the role of function and authority of the organ of the foundation must be clearly stated in the articles of association, so as not to cause a dispute in the future.KEYWORDS: Notaries, Foundation, Organ Foundation,

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