The Role of Type 2 Fibroblast Growth Factor in Periodontal Therapy

: The prevalence of periodontitis is around 20-50% of global population. If not treated, it can cause of tooth loss. Periodontal treatment aims at preserving the patient's teeth from various methods, including infection control and restoring lost periodontal tissue. The periodontium has great biological regenerative potential, and several biomaterials can be used to improve the outcome of periodontal treatment. To achieve the goal of periodontal tissue regeneration, numerous studies have used fibroblast growth factor 2 (FGF2) to stimulate regeneration of both soft tissue and bone. : FGF2 induced significant increment of the percentage of bone fill, bone mineral levels of the defect sites, length of the regenerated periodontal ligament, angiogenesis, connective tissue formation on the root surface, formation of dense fibers bound to alveolar bone and newly synthesized cementum in teeth. This review will open further avenues to better understand of FGF2 therapy for periodontal regeneration.