The Role of Type 2 Fibroblast Growth Factor in Periodontal Therapy

2020 ◽  
Vol 21 ◽  
Author(s):  
Hamideh Sadat Mohammadipour ◽  
Fatemeh Forouzanfar ◽  
Ali forouzanfar

: The prevalence of periodontitis is around 20-50% of global population. If not treated, it can cause of tooth loss. Periodontal treatment aims at preserving the patient's teeth from various methods, including infection control and restoring lost periodontal tissue. The periodontium has great biological regenerative potential, and several biomaterials can be used to improve the outcome of periodontal treatment. To achieve the goal of periodontal tissue regeneration, numerous studies have used fibroblast growth factor 2 (FGF2) to stimulate regeneration of both soft tissue and bone. : FGF2 induced significant increment of the percentage of bone fill, bone mineral levels of the defect sites, length of the regenerated periodontal ligament, angiogenesis, connective tissue formation on the root surface, formation of dense fibers bound to alveolar bone and newly synthesized cementum in teeth. This review will open further avenues to better understand of FGF2 therapy for periodontal regeneration.

2020 ◽  
Vol 10 (11) ◽  
pp. 1802-1807
Author(s):  
Haiying Wang ◽  
Yanmin Wu ◽  
Zhengyu Yao ◽  
Cong Wang

Tissue engineering technology provides a new method for periodontal regeneration. Finding or preparing a suitable scaffold is the key to periodontal tissue engineering. Here, we use nano-hydroxyapatite-modified collagen biomimetic material (nHAC) as the packaging material, and carry fibroblast growth factor (bFGF) for the regeneration and repair of periodontal tissue. Due to its low cytotoxicity and high biocompatibility, nHAC shows unique advantages in the construction of periodontal tissue scaffolds. The nHAC periodontal tissue scaffold material has a dense and porous three-dimensional network structure, has a high loading rate of bFGF, and can firmly lock human periodontal ligament cells (HPDLCs), which is easy for cell growth and attachment. In vivo experiments have shown that, in artificial animal periodontal tissue models, the nHAC-loaded bFGF periodontal scaffold covered by Geistlich Bio-Gide (GBG) membrane is better than the simple GBG membrane and the blank group, the nHAC/bFGF-GBG composite membrane It is beneficial to promote the growth of new alveolar bone and cement formation, and realize the regeneration of periodontal tissue.


2016 ◽  
Vol 58 (1) ◽  
pp. 137-140
Author(s):  
Naoto Yoshinuma ◽  
Ryosuke Koshi ◽  
Kazuhiro Kawamoto ◽  
Masataka Idesawa ◽  
Naoyuki Sugano ◽  
...  

PLoS ONE ◽  
2008 ◽  
Vol 3 (7) ◽  
pp. e2611 ◽  
Author(s):  
Masahiro Kitamura ◽  
Keisuke Nakashima ◽  
Yusuke Kowashi ◽  
Takeo Fujii ◽  
Hidetoshi Shimauchi ◽  
...  

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0131870 ◽  
Author(s):  
Toshie Nagayasu-Tanaka ◽  
Jun Anzai ◽  
Shu Takaki ◽  
Noriko Shiraishi ◽  
Akio Terashima ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document