Synthesis and Biological Properties of Dihydro-Oxadiazine-Based Heterocyclic Derivatives

Based on recent discoveries concerning the numerous biological properties of thiazolidinones and thiosemicarbazones, new N-substituted heterocyclic derivatives have been designed by combining the indole ring with thioxothiazolidinone, thiazolidinone or thiosemicarbazone. Thus, a series of new thioxothiazolidinone, thiazolidinone, or thiosemicarbazone derivatives bearing indole-based moiety have been designed, synthesized, and developed in good yields.

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Updated Report on Synthesis and Biological Properties of Oxadiazine-Based Heterocyclic Derivatives

Recent Advances in Medicinal Chemistry ◽

10.2174/9781681081717115020007 ◽

2015 ◽

pp. 107-143 ◽

Cited By ~ 1

Author(s):

Xiufang Cao ◽

Shaoyong Ke

Keyword(s):

Biological Properties ◽

Heterocyclic Derivatives

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ChemInform Abstract: SYNTHESIS AND BIOLOGICAL PROPERTIES OF SOME HETEROCYCLIC DERIVATIVES OF GUANIDINE

Chemischer Informationsdienst ◽

10.1002/chin.198050222 ◽

1980 ◽

Vol 11 (50) ◽

Author(s):

V. I. SHVEDOV ◽

V. F. VASIL'EVA ◽

I. YA. KORSAKOVA ◽

V. A. GALITSINA ◽

B. A. MEDVEDEV ◽

...

Keyword(s):

Biological Properties ◽

Heterocyclic Derivatives ◽

Derivatives Of

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Synthesis and study of heterocyclic derivatives with biological properties

Chemistry of Heterocyclic Compounds ◽

10.1007/bf00945388 ◽

1969 ◽

Vol 3 (3) ◽

pp. 442-443

Author(s):

Z. P. Penyugalova ◽

Z. V. Pushkareva

Keyword(s):

Biological Properties ◽

Heterocyclic Derivatives

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A Review on the Antitumor Activity of Various Nitrogenous-based Heterocyclic Compounds as NSCLC Inhibitors

Mini-Reviews in Medicinal Chemistry ◽

10.2174/1389557519666190312152358 ◽

2019 ◽

Vol 19 (18) ◽

pp. 1517-1530 ◽

Cited By ~ 5

Author(s):

Jia-Chun Liu ◽

Suresh Narva ◽

Kang Zhou ◽

Wen Zhang

Keyword(s):

Lung Cancer ◽

Antitumor Activity ◽

Heterocyclic Compounds ◽

Drug Effects ◽

Biological Properties ◽

Wide Range ◽

Heterocyclic Derivatives ◽

New Ideas ◽

Lung Cancer Therapy ◽

Nitrogen Heterocyclic

At present, cancers have been causing deadly fears to humans and previously unpredictable losses to health. Especially, lung cancer is one of the most common causes of cancer-related mortality accounting for approximately 15% of all cancer cases worldwide. While Non-Small Cell Lung Carcinomas (NSCLCs) makes up to 80% of lung cancer cases. The patient compliance has been weakening because of serious drug resistance and adverse drug effects. Therefore, there is an urgent need for the development of novel structural agents to inhibit NSCLCs. Nitrogen-containing heterocyclic compounds exhibit wide range of biological properties, especially antitumor activity. We reviewed some deadly defects of clinical medicines for the lung cancer therapy and importance of nitrogen based heterocyclic derivatives against NSCLCs. Nitrogen heterocycles exhibit significant antitumor activity against NSCLCs. Nitrogen heterocyclic hybrids could be developed as multi-target-directed NSCLC inhibitors and it is believed that the review is significant for rational designs and new ideas in the development of nitrogen heterocyclic-based drugs.

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Synthesis , identification and evaluation of antibacterial activity for some new heterocyclic derivatives from 4-methoxy-2-nitroaniline

Al-Qadisiyah Journal Of Pure Science ◽

10.29350/qjps.2021.26.4.1383 ◽

2021 ◽

Vol 26 (4) ◽

Author(s):

Sabah Matrood Mezaal ◽

Shaimaa Adnan

Keyword(s):

Antibacterial Activity ◽

Aromatic Amine ◽

Anthranilic Acid ◽

Biological Properties ◽

Heterocyclic Derivatives ◽

Ft Ir ◽

Imine Compounds ◽

C Nmr

This research involved synthesis. novel heterocyclic derivatives (quinazoline and thiazinone) derivatives , this compounds prepared from starting react (4-methoxy-2-nitroaniline) with 2,4-dimethoxyacetophenone to gate azo derivative (A) , (A) interact with aromatic amine derivatives to produce imine compounds (B1-B2), imine derivatives interact with (anthranilic acid , 2-mercaptobenzoic) to get heterocyclic derivatives quinazoline (C1-C2) and thiazinone (D1-D2 ) . All these compound characterized by13 C-NMR , FT-IR , 1HMNR . Then that,we studies the,biological,properties for,all heterocyclic derivatives,to,ward.two different kindof bacteria.

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Three Dimensional structure and organization of diploid chromosomes by optical section microscopy

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100127608 ◽

1987 ◽

Vol 45 ◽

pp. 633-635

Author(s):

David A. Agard ◽

Yasushi Hiraoka ◽

John W. Sedat

Keyword(s):

Dimensional Space ◽

Three Dimensional ◽

Developmental State ◽

Mitotic Cell ◽

Biological Properties ◽

Dimensional Structure ◽

Specific Gene ◽

Three Dimensional Structure ◽

Complementary Techniques ◽

Dynamic Structures

In an effort to understand the complex relationship between structure and biological function within the nucleus, we have embarked on a program to examine the three-dimensional structure and organization of Drosophila melanogaster embryonic chromosomes. Our overall goal is to determine how DNA and proteins are organized into complex and highly dynamic structures (chromosomes) and how these chromosomes are arranged in three dimensional space within the cell nucleus. Futher, we hope to be able to correlate structual data with such fundamental biological properties as stage in the mitotic cell cycle, developmental state and transcription at specific gene loci.Towards this end, we have been developing methodologies for the three-dimensional analysis of non-crystalline biological specimens using optical and electron microscopy. We feel that the combination of these two complementary techniques allows an unprecedented look at the structural organization of cellular components ranging in size from 100A to 100 microns.

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Membrane–cytoskeleton interactions in cholesterol-dependent domain formation

Essays in Biochemistry ◽

10.1042/bse0570177 ◽

2015 ◽

Vol 57 ◽

pp. 177-187 ◽

Cited By ~ 9

Author(s):

Jennifer N. Byrum ◽

William Rodgers

Keyword(s):

Biological Properties ◽

Membrane Rafts ◽

Membrane Domains ◽

Biological Functions ◽

Membrane Cytoskeleton ◽

Heterogeneous Structures ◽

Integral Role ◽

Model Cell ◽

Actomyosin Cytoskeleton ◽

Dependent Domain

Since the inception of the fluid mosaic model, cell membranes have come to be recognized as heterogeneous structures composed of discrete protein and lipid domains of various dimensions and biological functions. The structural and biological properties of membrane domains are represented by CDM (cholesterol-dependent membrane) domains, frequently referred to as membrane ‘rafts’. Biological functions attributed to CDMs include signal transduction. In T-cells, CDMs function in the regulation of the Src family kinase Lck (p56lck) by sequestering Lck from its activator CD45. Despite evidence of discrete CDM domains with specific functions, the mechanism by which they form and are maintained within a fluid and dynamic lipid bilayer is not completely understood. In the present chapter, we discuss recent advances showing that the actomyosin cytoskeleton has an integral role in the formation of CDM domains. Using Lck as a model, we also discuss recent findings regarding cytoskeleton-dependent CDM domain functions in protein regulation.

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