Blood-brain Barrier Drug Discovery for Central Nervous System Infections

2005 ◽  
Vol 5 (1) ◽  
pp. 65-72 ◽  
Author(s):  
Ambrose Jong ◽  
Sheng-He Huang
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Drug Discovery ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Central Nervous System Infections ◽  
Blood Brain

scholarly journals Drug metabolism and pharmacokinetics, the blood-brain barrier, and central nervous system drug discovery

NeuroRx ◽  
2005 ◽  
Vol 2 (4) ◽  
pp. 554-571 ◽  
Author(s):  
Mohammad S. Alavijeh ◽  
Mansoor Chishty ◽  
M. Zeeshan Qaiser ◽  
Alan M. Palmer
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Drug Discovery ◽  
Drug Metabolism ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Central Nervous System Drug ◽  
Blood Brain

scholarly journals Proposed Therapies for Pantothenate-Kinase-Associated Neurodegeneration

2019 ◽  
Vol 13 ◽  
pp. 117906951985111 ◽  
Author(s):  
Suzanne Jackowski
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Drug Discovery ◽  
Neurodegenerative Disease ◽  
Blood Brain Barrier ◽  
Medicinal Chemistry ◽  
Clinical Development ◽  
Brain Barrier ◽  
Pantothenate Kinase ◽  
Blood Brain

Multiple approaches to therapy have been proposed for the rare inherited neurodegenerative disease associated with mutations in the PANK2 gene, called pantothenate-kinase-associated neurodegeneration (PKAN). Penetration of the blood-brain barrier for treatment of a central nervous system (CNS) disorder is a major challenge in drug discovery. Evaluation of the biochemistry and medicinal chemistry of the proposed therapies reveals potential liabilities among several compounds under consideration for clinical development.

scholarly journals Central nervous system delivery of molecules across the blood-brain barrier

2021 ◽  
pp. 104952
Author(s):  
Fabien Gosselet ◽  
Rodrigo Azevedo Loiola ◽  
Anna Roig ◽  
Anna Rosell ◽  
Maxime Culot
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain

Understanding the Physiology of the Blood-Brain Barrier: In Vitro Models

Physiology ◽  
1998 ◽  
Vol 13 (6) ◽  
pp. 287-293 ◽  
Author(s):  
Gerald A. Grant ◽  
N. Joan Abbott ◽  
Damir Janigro
Keyword(s):  
Central Nervous System ◽  
Tissue Culture ◽  
Nervous System ◽  
Blood Brain Barrier ◽  
In Vitro Models ◽  
Brain Barrier ◽  
Blood Brain ◽  
Brain Tissue Culture ◽  
The Brain

Endothelial cells exposed to inductive central nervous system factors differentiate into a blood-brain barrier phenotype. The blood-brain barrier frequently obstructs the passage of chemotherapeutics into the brain. Tissue culture systems have been developed to reproduce key properties of the intact blood-brain barrier and to allow for testing of mechanisms of transendothelial drug permeation.

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