The effect of aluminium chloride upon the transition of drugs through the blood-brain barrier into the central nervous system

1991 ◽  
Vol 16 (3) ◽  
pp. 171-175 ◽  
Author(s):  
V. Jakovljević ◽  
B. Banić ◽  
A. Radunović
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Blood Brain Barrier ◽  
Aluminium Chloride ◽  
Brain Barrier ◽  
Blood Brain ◽  
The Central Nervous System

Active Transport of High-Affinity Choline and Nicotine Analogs into the Central Nervous System by the Blood-Brain Barrier Choline Transporter

2002 ◽  
Vol 304 (3) ◽  
pp. 1268-1274 ◽  
Author(s):  
David D. Allen ◽  
Paul R. Lockman ◽  
Karen E. Roder ◽  
Linda P. Dwoskin ◽  
Peter A. Crooks
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Blood Brain Barrier ◽  
Active Transport ◽  
Brain Barrier ◽  
Choline Transporter ◽  
High Affinity ◽  
Blood Brain ◽  
The Central Nervous System ◽  
Nicotine Analogs

scholarly journals Angubindin-1 opens the blood–brain barrier in vivo for delivery of antisense oligonucleotide to the central nervous system

2018 ◽  
Vol 283 ◽  
pp. 126-134 ◽  
Author(s):  
Satoshi Zeniya ◽  
Hiroya Kuwahara ◽  
Kaiichi Daizo ◽  
Akihiro Watari ◽  
Masuo Kondoh ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Blood Brain Barrier ◽  
Antisense Oligonucleotide ◽  
Brain Barrier ◽  
Blood Brain ◽  
The Central Nervous System

The Blood-Brain Barrier and the Immune Privilege of the Central Nervous System

2015 ◽  
pp. 215-238 ◽  
Author(s):  
Benjamin Clarkson ◽  
Melissa Harris ◽  
Aditya Rayasam ◽  
Zsuzsanna Fabry
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Blood Brain Barrier ◽  
Immune Privilege ◽  
Brain Barrier ◽  
Blood Brain ◽  
The Central Nervous System

scholarly journals Permeability of the Blood-Brain Barrier and Transport of Nanobodies Across the Blood-Brain Barrier

2018 ◽  
Vol 62 (1) ◽  
pp. 59-66 ◽  
Author(s):  
I. Širochmanová ◽  
Ľ. Čomor ◽  
E. Káňová ◽  
I. Jiménez-Munguía ◽  
Z. Tkáčová ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Blood Brain Barrier ◽  
Chemical Properties ◽  
Cost Effective ◽  
Central Nervous System Disease ◽  
Brain Barrier ◽  
Promising Alternative ◽  
Blood Brain ◽  
The Central Nervous System

Abstract The presence of a blood-brain barrier (BBB) and a blood-cerebrospinal fluid barrier presents animmense challenge for effective delivery of therapeutics to the central nervous system. Many potential drugs, which are effective at their site of action, have failed due to the lack of distribution in sufficient quantity to the central nervous system (CNS). In consequence, many diseases of the central nervous system remain undertreated. Antibodies, IgG for example, are difficult to deliver to the CNS due to their size (~155 kDa), physico-chemical properties and the presence of Fc receptor on the blood-brain barrier. Smaller antibodies, like the recently developed nanobodies, may overcome the obstacle of the BBB and enter into the CNS. The nanobodies are the smallest available antigen-binding fragments harbouring the full antigenbinding capacity of conventional antibodies. They represent a new generation of therapeutics with exceptional properties, such as: recognition of unique epitopes, target specificity, high affinity, high solubility, high stability and high expression yields in cost-effective recombinant production. Their ability to permeate across the BBBmakes thema promising alternative for central nervous system disease therapeutics. In this review, we have systematically presented different aspects of the BBB, drug delivery mechanisms employed to cross the BBB, and finally nanobodies — a potential therapeutic molecule against neuroinfections.

Investigation of the effect of active efflux at the blood–brain barrier on the distribution of nonsteroidal aromatase inhibitors in the central nervous system

2013 ◽  
Vol 102 (9) ◽  
pp. 3309-3319 ◽  
Author(s):  
Mari Miyajima ◽  
Hiroyuki Kusuhara ◽  
Kayo Takahashi ◽  
Tadayuki Takashima ◽  
Takamitsu Hosoya ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Blood Brain Barrier ◽  
Aromatase Inhibitors ◽  
Brain Barrier ◽  
Active Efflux ◽  
Blood Brain ◽  
The Central Nervous System ◽  
Nonsteroidal Aromatase Inhibitors
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