Inhibition of Type 1 Diabetes Development by Vitamin D Receptor Agonists

2005 ◽  
Vol 4 (6) ◽  
pp. 645-651 ◽  
Author(s):  
Luciano Adorini ◽  
Giuseppe Penna ◽  
Nadia Giarratana ◽  
Roberto Mariani ◽  
Milan Uskokovic
Keyword(s):  
Vitamin D ◽  
Type 1 Diabetes ◽  
Vitamin D Receptor ◽  
Receptor Agonists ◽  
Diabetes Development

scholarly journals Vitamin D receptor initiation codon polymorphism influences genetic susceptibility to type 1 diabetes mellitus in the Japanese population

2001 ◽  
Vol 2 (1) ◽  
Author(s):  
Yoshiyuki Ban ◽  
Matsuo Taniyama ◽  
Tatsuo Yanagawa ◽  
Satoru Yamada ◽  
Taro Maruyama ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Genetic Susceptibility ◽  
Vitamin D Receptor ◽  
Japanese Population ◽  
Initiation Codon

Association Between Vitamin D Receptor Genotype and Age of Onset in Juvenile Japanese Patients With Type 1 Diabetes

Diabetes Care ◽  
2002 ◽  
Vol 25 (7) ◽  
pp. 1244-1244 ◽  
Author(s):  
I. Yokota ◽  
S. Satomura ◽  
S. Kitamura ◽  
Y. Taki ◽  
E. Naito ◽  
...  
Keyword(s):  
Vitamin D ◽  
Type 1 Diabetes ◽  
Vitamin D Receptor ◽  
Age Of Onset ◽  
Japanese Patients

scholarly journals Staphylococcus aureus nasal carriage might be associated with vitamin D receptor polymorphisms in type 1 diabetes

2009 ◽  
Vol 13 (6) ◽  
pp. e437-e443 ◽  
Author(s):  
Charalambos Panierakis ◽  
George Goulielmos ◽  
Dimitris Mamoulakis ◽  
Sofia Maraki ◽  
Efstathios Papavasiliou ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Vitamin D ◽  
Type 1 Diabetes ◽  
Vitamin D Receptor ◽  
Nasal Carriage

scholarly journals FokI Polymorphism, Vitamin D Receptor, and Interleukin-1 Receptor Haplotypes Are Associated with Type 1 Diabetes in the Dalmatian Population

2005 ◽  
Vol 7 (5) ◽  
pp. 600-604 ◽  
Author(s):  
Tatijana Zemunik ◽  
Veselin Škrabić ◽  
Vesna Boraska ◽  
Dijaneta Diklić ◽  
Ivana Marinović Terzić ◽  
...  
Keyword(s):  
Vitamin D ◽  
Type 1 Diabetes ◽  
Vitamin D Receptor ◽  
Interleukin 1 ◽  
Foki Polymorphism

scholarly journals Vitamin D receptor gene polymorphisms and the risk of the type 1 diabetes: a meta-analysis based on 40 case–control studies

2020 ◽  
Author(s):  
Na Zhai ◽  
Ramtin Bidares ◽  
Masoud Hassanzadeh Makoui ◽  
Saeed Aslani ◽  
Payam Mohammadi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Type 1 Diabetes ◽  
Vitamin D Receptor ◽  
Subgroup Analysis ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Receptor Gene ◽  
Case Control ◽  
Case Control Studies

Abstract Background: The association between the polymorphisms in the vitamin D receptor (VDR) gene and the risk of type 1 diabetes mellitus (T1DM) has been evaluated in several studies. However, the findings were inconclusive. Thus, we conducted a meta-analysis to comprehensively evaluate the effect of VDR gene polymorphisms on the risk of T1DM.Methods: All relevant studies reporting the association between VDR gene polymorphisms and susceptibility to T1DM published up to May 2020 were identified by comprehensive systematic database search in ISI Web of Science, Scopus, and PubMed/MEDLINE. Strength of association were assessed by calculating of pooled odds ratios (ORs) and 95% confidence intervals (CIs). The methodological quality of each study was assessed according to the Newcastle–Ottawa Scale. To find the potential sources of heterogeneity, meta-regression and subgroup analysis were also performed. Results: A total of 40 case–control studies were included in this meta-analysis. The results of overall population rejected any significant association between VDR gene polymorphisms and T1DM risk. However, the pooled results of subgroup analysis revealed significant negative and positive associations between FokI and BsmI polymorphisms and T1DM in Africans and Americans, respectively. Conclusions: This meta-analysis suggested a significant association between VDR gene polymorphism and T1DM susceptibility in ethnic-specific analysis.

scholarly journals Association of vitamin D receptor polymorphisms and type 1 diabetes susceptibility in children: a meta-analysis

2017 ◽  
Vol 6 (3) ◽  
pp. 159-171 ◽  
Author(s):  
Ozlem Atan Sahin ◽  
Damla Goksen ◽  
Aysel Ozpinar ◽  
Muhittin Serdar ◽  
Huseyin Onay
Keyword(s):  
Vitamin D ◽  
Type 1 Diabetes ◽  
Vitamin D Receptor ◽  
Meta Analysis ◽  
Vdr Gene ◽  
Increased Risk ◽  
Funnel Plots ◽  
Type 1 Dm ◽  
Study Inclusion

Background There have been studies focused on FokI, BsmI, ApaI and TaqI polymorphisms of the vitamin D receptor (VDR) gene and susceptibility to type 1 diabetes mellitus with controversial results. Methods This present study is a meta-analysis investigating the association between FokI, ApaI, TaqI and BsmI polymorphisms of VDR gene and type 1 DM in children. A literature search was performed using Medline, EMBASE, Cochrane and PubMed. Any study was considered eligible for inclusion if at least one of FokI, ApaI, TaqI and BsmI polymorphisms was determined, and outcome was type 1 DM at pediatric age. Results A total of 9 studies comprising 1053 patients and 1017 controls met the study inclusion criteria. The pooled odds ratios (ORs) of the FokI, ApaI, TaqI and BsmI polymorphisms were combined and calculated. Forest plots and funnel plots of the OR value distributions were drawn. Our meta-analysis has demonstrated statistically significant associations between DM1 and VDR genotypes, BsmIBB (P < 0.05), BsmIBb, (P < 0.05), BsmIbb (P < 0.05), TaqITT (P < 0.05) and TaqItt (P < 0.05) in children. Conclusion The results indicated that BsmIBB, BsmIBb and TaqItt polymorphisms were associated with an increased risk of type 1 DM, whereas BsmIbb and TaqITT had protective effect for type 1 DM in children.

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