Editorial (Thematic Issue: Novel Pharmaceutical Approaches by Natural Compound-Derived Epigenetic Regulators: Epigenetic Readers, Writers and Erasers as Therapeutic Targets)

2015 ◽  
Vol 16 (7) ◽  
pp. 677-679 ◽  
Author(s):  
Michael Schnekenburger ◽  
Cristina Florean ◽  
Cindy Grandjenette ◽  
Marc Diederich
Keyword(s):  
Natural Compound ◽  
Therapeutic Targets ◽  
Thematic Issue ◽  
Epigenetic Regulators

HOX genes as transcriptional and epigenetic regulators during tumorigenesis and their value as therapeutic targets

Epigenomics ◽  
2019 ◽  
Vol 11 (13) ◽  
pp. 1539-1552
Author(s):  
Ana Paço ◽  
Renata Freitas
Keyword(s):  
Tumor Suppressor Genes ◽  
Hox Genes ◽  
Therapeutic Targets ◽  
Transcriptional Regulators ◽  
Gene Products ◽  
Wide Range ◽  
History Of ◽  
Epigenetic Regulators ◽  
Potential Use

Several HOX genes are aberrantly expressed in a wide range of cancers interfering with their development and resistance to treatment. This seems to be often caused by alterations in the methylation profiles of their promoters. The role of HOX gene products in cancer is highly ‘tissue specific’, relying ultimately on their ability to regulate oncogenes or tumor-suppressor genes, directly as transcriptional regulators or indirectly interfering with the levels of epigenetic regulators. Nowadays, different strategies have been tested the use of HOX genes as therapeutic targets for cancer diagnosis and treatment. Here, we trace the history of the research concerning the involvement of HOX genes in cancer, their connection with epigenetic regulation and their potential use as therapeutic targets.

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