Recent Progress on the Discovery of Sirt2 Inhibitors for the Treatment of Various Cancers

2019 ◽  
Vol 19 (12) ◽  
pp. 1051-1058 ◽  
Author(s):  
Ting Wang ◽  
Zhuyu Xu ◽  
Yongping Lu ◽  
Jianyou Shi ◽  
Wenbo Liu ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Biological Activity ◽  
Inflammatory Response ◽  
Cell Cycle Regulation ◽  
Recent Progress ◽  
Biological Processes ◽  
Target Structure ◽  
Action Mechanism ◽  
Dependent Protein ◽  
Cycle Regulation

Sirtuins family is a class of NDA+ dependent protein deacetylases that play a key role in the regulation of several aspects of biological processes, such as cell cycle regulation, autophagy, immune and inflammatory response. Many studies have shown that sirtuins2 as a key player in the cancer pathway is of great significance in tumorigenesis. This review summarizes the newly discovered, in recent years, some SIRT2 inhibitors for cancer target structure, action mechanism, biological activity, substrate specificity, and signaling pathways.

scholarly journals Phosphorylation-Dependent Protein Interactions at the Spindle Midzone Mediate Cell Cycle Regulation of Spindle Elongation

2009 ◽  
Vol 17 (2) ◽  
pp. 244-256 ◽  
Author(s):  
Anton Khmelinskii ◽  
Johanna Roostalu ◽  
Helio Roque ◽  
Claude Antony ◽  
Elmar Schiebel
Keyword(s):  
Cell Cycle ◽  
Protein Interactions ◽  
Cell Cycle Regulation ◽  
Spindle Midzone ◽  
Dependent Protein ◽  
Spindle Elongation ◽  
Mediate Cell ◽  
Cycle Regulation

scholarly journals Gene co-expression analysis of human RNASEH2A reveals functional networks associated with DNA replication, DNA damage response, and cell cycle regulation

2020 ◽  
Author(s):  
Stefania Marsili ◽  
Ailone Tichon ◽  
Francesca Storici
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Dna Replication ◽  
Dna Damage Response ◽  
Cell Cycle Regulation ◽  
Functional Networks ◽  
Biological Processes ◽  
Damage Response ◽  
Rnase H2 ◽  
Cycle Regulation

AbstractRibonuclease H2 (RNase H2) is a key enzyme for the removal of RNA found in DNA-RNA hybrids, playing a fundamental role in biological processes such as DNA replication, telomere maintenance and DNA damage repair. RNase H2 is a trimer composed of three subunits, being RNASEH2A the catalytic subunit. RNASEH2A expression levels have been shown to be upregulated in transformed and cancer cells. In this study we used a bioinformatics approach to identify RNASEH2A co-expressed genes in different human tissues to uncover biological processes in which RNASEH2A is involved. By implementing this approach, we identified functional networks for RNASEH2A that are not only involved in the processes of DNA replication and DNA damage response, but also in cell cycle regulation. Additional examination of protein-protein networks for RNASEH2A by the STRING database analysis, revealed a high co-expression correlation between RNASEH2A and the genes of the protein networks identified. Mass spectrometry analysis of RNASEH2A-bound proteins highlighted players functioning in cell cycle regulation. Further bioinformatics investigation showed increased gene expression of RNASEH2A in different types of actively cycling cells and tissues, and particularly in several cancers, supporting a biological role for RNASEH2A, but not the other two subunits of RNase H2, in cell proliferation.

scholarly journals Dynamic ubiquitin signaling in cell cycle regulation

2017 ◽  
Vol 216 (8) ◽  
pp. 2259-2271 ◽  
Author(s):  
Samuel Gilberto ◽  
Matthias Peter
Keyword(s):  
Cell Cycle ◽  
Posttranslational Modifications ◽  
Cell Cycle Regulation ◽  
Effector Proteins ◽  
Biological Processes ◽  
Genomic Information ◽  
Chromosomal Proteins ◽  
Regulated Expression ◽  
Cycle Regulation ◽  
Fine Tune

The cell division cycle is driven by a collection of enzymes that coordinate DNA duplication and separation, ensuring that genomic information is faithfully and perpetually maintained. The activity of the effector proteins that perform and coordinate these biological processes oscillates by regulated expression and/or posttranslational modifications. Ubiquitylation is a cardinal cellular modification and is long known for driving cell cycle transitions. In this review, we emphasize emerging concepts of how ubiquitylation brings the necessary dynamicity and plasticity that underlie the processes of DNA replication and mitosis. New studies, often focusing on the regulation of chromosomal proteins like DNA polymerases or kinetochore kinases, are demonstrating that ubiquitylation is a versatile modification that can be used to fine-tune these cell cycle events, frequently through processes that do not involve proteasomal degradation. Understanding how the increasing variety of identified ubiquitin signals are transduced will allow us to develop a deeper mechanistic perception of how the multiple factors come together to faithfully propagate genomic information. Here, we discuss these and additional conceptual challenges that are currently under study toward understanding how ubiquitin governs cell cycle regulation.

scholarly journals Gene Co-Expression Analysis of Human RNASEH2A Reveals Functional Networks Associated with DNA Replication, DNA Damage Response, and Cell Cycle Regulation

Biology ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 221
Author(s):  
Stefania Marsili ◽  
Ailone Tichon ◽  
Deepali Kundnani ◽  
Francesca Storici
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Dna Replication ◽  
Dna Damage Response ◽  
Cell Cycle Regulation ◽  
Functional Networks ◽  
Biological Processes ◽  
Damage Response ◽  
Rnase H2 ◽  
Cycle Regulation

Ribonuclease (RNase) H2 is a key enzyme for the removal of RNA found in DNA-RNA hybrids, playing a fundamental role in biological processes such as DNA replication, telomere maintenance, and DNA damage repair. RNase H2 is a trimer composed of three subunits, RNASEH2A being the catalytic subunit. RNASEH2A expression levels have been shown to be upregulated in transformed and cancer cells. In this study, we used a bioinformatics approach to identify RNASEH2A co-expressed genes in different human tissues to underscore biological processes associated with RNASEH2A expression. Our analysis shows functional networks for RNASEH2A involvement such as DNA replication and DNA damage response and a novel putative functional network of cell cycle regulation. Further bioinformatics investigation showed increased gene expression in different types of actively cycling cells and tissues, particularly in several cancers, supporting a biological role for RNASEH2A but not for the other two subunits of RNase H2 in cell proliferation. Mass spectrometry analysis of RNASEH2A-bound proteins identified players functioning in cell cycle regulation. Additional bioinformatic analysis showed that RNASEH2A correlates with cancer progression and cell cycle related genes in Cancer Cell Line Encyclopedia (CCLE) and The Cancer Genome Atlas (TCGA) Pan Cancer datasets and supported our mass spectrometry findings.

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