Synthesis of a Novel Class of 1,3-oxathiolane Nucleoside Derivatives of T- 705 and Evaluation of Their Anti-influenza A Virus and Anti-HIV Activity

2018 ◽  
Vol 14 (6) ◽  
pp. 595-603 ◽  
Author(s):  
Mingming Han ◽  
Xu Zhao ◽  
Xuedong Wu ◽  
Wei Huang ◽  
Xingzhou Li ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Derivatives Of ◽  
Anti Hiv

scholarly journals Synthesis and in vitro study of novel borneol derivatives as potent inhibitors of the influenza A virus

MedChemComm ◽  
2017 ◽  
Vol 8 (5) ◽  
pp. 960-963 ◽  
Author(s):  
A. S. Sokolova ◽  
O. I. Yarovaya ◽  
M. D. Semenova ◽  
A. A. Shtro ◽  
I. R. Orshanskaya ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
In Vitro Study ◽  
Vitro Study ◽  
Design And Synthesis ◽  
Heterocyclic Derivatives ◽  
Derivatives Of

Herein, we present the design and synthesis of a series of novel heterocyclic derivatives of (−)-borneol and (−)-isoborneol as potent inhibitors of the influenza A virus.

Synthesis of novel derivatives of 7,8-dihydro-6H -imidazo[2,1-b ][1,3]benzothiazol-5-one and their virus-inhibiting activity against influenza A virus

2018 ◽  
Vol 352 (2) ◽  
pp. 1800225 ◽  
Author(s):  
Anastasia V. Galochkina ◽  
Rakesh K. Bollikanda ◽  
Vladimir V. Zarubaev ◽  
Dmitry G. Tentler ◽  
Irina N. Lavrenteva ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Inhibiting Activity ◽  
Derivatives Of

Anti-influenza A virus activity of uridine derivatives of 2-deoxy sugars

2013 ◽  
Vol 100 (1) ◽  
pp. 90-97 ◽  
Author(s):  
Ewelina Krol ◽  
Ilona Wandzik ◽  
Beata Gromadzka ◽  
Dawid Nidzworski ◽  
Malgorzata Rychlowska ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Virus Activity ◽  
Derivatives Of ◽  
Deoxy Sugars

scholarly journals Synthesis and antiviral activities of spacer-linked 1-thioglucuronide analogues of glycyrrhizin

2012 ◽  
Vol 8 ◽  
pp. 705-711 ◽  
Author(s):  
Christian Stanetty ◽  
Andrea Wolkerstorfer ◽  
Hassan Amer ◽  
Andreas Hofinger ◽  
Ulrich Jordis ◽  
...  
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Influenza Virus Infection ◽  
Glycyrrhetinic Acid ◽  
Antiviral Compounds ◽  
Antiviral Activities ◽  
Infected Cells ◽  
Amino Derivatives ◽  
Derivatives Of

The influenza virus infection remains a significant threat to public health and the increase of antiviral resistance to available drugs generates an urgent need for new antiviral compounds. Starting from the natural, antivirally active compound glycyrrhizin, spacer-bridged derivatives were generated with improved antiviral activity against the influenza A virus infection. Simplified analogues of the triterpene saponin glycyrrhizin containing 1-thio-β-D-glucuronic acid residues have been prepared in good yields by alkylation of 3-amino and 3-thio derivatives of glycyrrhetinic acid with a 2-iodoethyl 1-thio-β-D-glucopyranosiduronate derivative. The spacer-connected 3-amino derivatives were further transformed into N-acetylated and N-succinylated derivatives. The deprotected compounds containing these carboxylic acid appendices mimic the glycon part of glycyrrhizin as well as the hemisuccinate derivative of glycyrrhetinic acid, carbenoxolone. Antiviral activities of the compounds were determined in a biological test based on influenza A virus-infected cells, wherein the 3-(2-thioethyl)-N-acetylamino- and 3-(2-thioethyl)-thio-linked glucuronide derivatives were effective inhibitors with IC50 values as low as 54 µM.

scholarly journals Inhibition of Human Immunodeficiency Virus Type 1 Replication prior to Reverse Transcription by Influenza Virus Stimulation

2000 ◽  
Vol 74 (10) ◽  
pp. 4505-4511 ◽  
Author(s):  
Ligia A. Pinto ◽  
Vesna Blazevic ◽  
Bruce K. Patterson ◽  
C. Mac Trubey ◽  
Matthew J. Dolan ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Influenza A Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Reverse Transcription ◽  
Influenza A ◽  
Immunodeficiency Virus ◽  
Anti Hiv ◽  
Hiv 1

ABSTRACT It is now recognized that, in addition to drug-mediated therapies against human immunodeficiency virus type 1 (HIV-1), the immune system can exert antiviral effects via CD8+ T-cell-generated anti-HIV factors. This study demonstrates that (i) supernatants from peripheral blood mononuclear cells (PBMC) stimulated with influenza A virus inhibit replication of CCR5- and CXCR4-tropic HIV-1 isolates prior to reverse transcription; (ii) the HIV-suppressive supernatants can be generated by CD4- or CD8-depleted PBMC; (iii) this anti-HIV activity is partially due to alpha interferon (IFN-α), but not to IFN-γ, IFN-β, the β-chemokines MIP-1α, MIP-1β, and RANTES, or interleukin-16; (iv) the anti-HIV activity is generated equally well by PBMC cultured with either infectious or UV-inactivated influenza A virus; and (v) the antiviral activity can be generated by influenza A-stimulated PBMC from HIV-infected individuals. These findings represent a novel mechanism for inhibition of HIV-1 replication that differs from the previously described CD8 anti-HIV factors (MIP-1α, MIP-1β, RANTES, and CD8 antiviral factor).

Novel derivatives of usnic acid effectively inhibiting reproduction of influenza A virus

2014 ◽  
Vol 22 (24) ◽  
pp. 6826-6836 ◽  
Author(s):  
Anna A. Shtro ◽  
Vladimir V. Zarubaev ◽  
Olga A. Luzina ◽  
Dmitry N. Sokolov ◽  
Oleg I. Kiselev ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Usnic Acid ◽  
Derivatives Of

scholarly journals Discovery of Potent Sialic Acid Inhibitors Against the Hemagglutinin of Influenza A Virus

2020 ◽  
Author(s):  
Yu-Jen Chang ◽  
Cheng-Yun Yeh ◽  
Ju-Chien Cheng ◽  
Yu-Qi Huang ◽  
Kai-Cheng Hsu ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Influenza A Virus ◽  
Influenza A ◽  
Site Model ◽  
Docking Method ◽  
Ranking Score ◽  
Model Preparation ◽  
Derivatives Of ◽  
Infectious Cycle

Abstract Influenza A virus (IAV) is hard to eradicate due to its genetic drift and reassortment ability. Neuraminidase (NA), frequently the target protein, cleaves the sialic acid (SA) and discharges virions to complete the infectious cycle. However, the increasing use of NA inhibitors aroused drug resistance in recent years. Hemagglutinin (HA), on the opposite, initiates the infectious cycle and sticks virions to cells by connecting to the host SA so that HA might be a tempting target. In this study, HA was chosen for SA-binding site model preparation to screen more than 200,000 compounds by molecular docking method in silico. According to the post-screening analysis by iGemdock and SiMMap, nine of the top twenty compounds based on the ranking score were purchased and evaluated. NSC85561 was initially identified from the compounds through the bioassays. Next, the twelve derivatives of NSC85561 were selected to consolidate the primary results. NSC85561 and two of its derivatives were finally identified as potent HA inhibitors by cell proliferation, plaque reduction, and hemagglutination inhibition assays in vitro. These results suggested that virtual screening may be a powerful tool to concise the compounds from the massive database and reduce the complicated bioassays.

Antiviral effect of polyphenol-enriched extract of Rumex Acetosa L. against Influenza A virus

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
A Derksen ◽  
W Hafezi ◽  
A Hensel ◽  
J Kühn
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Antiviral Effect ◽  
Rumex Acetosa
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