Modeling Anti-HIV Compounds: The Role of Analogue-Based Approaches

CVN (cyanovirin-N), a small lectin isolated from cyanobacteria, exemplifies a novel class of anti-HIV agents that act by binding to the highly glycosylated envelope protein gp120 (glycoprotein 120), resulting in inhibition of the crucial viral entry step. In the present review, we summarize recent work in our laboratory and others towards determining the crucial role of multivalency in the antiviral activity, and we discuss features that contribute to the high specificity and affinity for the glycan ligand observed in CVN. An integrated approach that encompasses structural determination, mutagenesis analysis and computational work holds particular promise to clarify aspects of the interactions between CVN and glycans.

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Crystal Forms of Anti-HIV Drugs: Role of Recrystallization

Recrystallization ◽

10.5772/33777 ◽

2012 ◽

Author(s):

Renu Chadha ◽

Poonam Arora ◽

Anupam Saini ◽

Swati Bhandari

Keyword(s):

Crystal Forms ◽

Hiv Drugs ◽

Anti Hiv

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Role of Complement Receptors (CRs) on DCs in Anti-HIV-1 Immunity

Frontiers in Immunology ◽

10.3389/fimmu.2020.572114 ◽

2020 ◽

Vol 11 ◽

Author(s):

Wilfried Posch ◽

Marta Bermejo-Jambrina ◽

Cornelia Lass-Flörl ◽

Doris Wilflingseder

Keyword(s):

Complement Receptors ◽

Anti Hiv ◽

Hiv 1

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The critical role of human transcriptional repressor CTCF mRNA up-regulation in the induction of anti-HIV-1 responses in CD4+ T cells

Immunology Letters ◽

10.1016/j.imlet.2007.11.017 ◽

2008 ◽

Vol 117 (1) ◽

pp. 35-44 ◽

Cited By ~ 6

Author(s):

Yuchang Li ◽

Guanhua Li ◽

Anna Ivanova ◽

Sagiv Aaron ◽

Malgorzata Simm

Keyword(s):

T Cells ◽

Cd4 T Cells ◽

Critical Role ◽

Transcriptional Repressor ◽

Anti Hiv ◽

Hiv 1

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Role of screening for anti-HIV antibodies in patients treated in large multidisciplinary hospitals

Infekcionnye bolezni ◽

10.20953/1729-9225-2019-2-5-11 ◽

2019 ◽

Vol 17 (2) ◽

pp. 5-11 ◽

Cited By ~ 1

Author(s):

E.N. Kudryavtseva ◽

◽

T.A. Semenenko ◽

M.A. Godkov ◽

O.N. Ershova ◽

...

Keyword(s):

Hiv Antibodies ◽

Anti Hiv

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REVIEW OF HIV MODELS: THE ROLE OF THE NATURAL IMMUNE RESPONSE AND IMPLICATIONS FOR TREATMENT

Journal of Biological System ◽

10.1142/s0218339004001099 ◽

2004 ◽

Vol 12 (02) ◽

pp. 123-135 ◽

Cited By ~ 4

Author(s):

REBECCA V. CULSHAW

Keyword(s):

Immune Response ◽

Optimal Treatment ◽

Minimal Cost ◽

Treatment Scenario ◽

Forcing Function ◽

Drug Regimens ◽

Differential Equations Models ◽

Anti Hiv ◽

Hiv 1

We present a review and comparison of several recent differential equations models of treatment of HIV-1 infection. We seek to clarify the role of the natural anti-HIV immune response and determine its effect upon optimal treatment schemes. In this paper, we consider systems in which treatment is expressed as a forcing function, as well as those in which we determine optimal treatment via control theoretic techniques. The primary goal of this study is to compare treatment schemes for systems in which a natural nonconstant immune response of the patient is considered explicitly with those that consider implicitly a constant non-specific immune response. We find that when the natural immune response can be boosted sufficiently, drug levels may not need to be as high as previously supposed. This implies that a treatment scenario in which intervals of drug treatment are alternated with some form of immune-boosting therapy may be highly beneficial in terms of reducing toxicity to the patient. Additionally, in developing countries where HIV infection is widespread and sufficient funds are not available to supply rigourous drug regimens, the implications of these models are profound, as they suggest methods of treating HIV at a minimal cost.

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