Exploring the Molecular Mechanism of Action Between Drug and RNA Polymerase Based on Partially-Resolved Spatial Structures

2013 ◽  
Vol 9 (4) ◽  
pp. 547-555 ◽  
Author(s):  
Yajun Sheng ◽  
Chen Zhang ◽  
Xingye Qiu ◽  
Wei Zheng ◽  
Jishou Ruan ◽  
...  
Keyword(s):  
Rna Polymerase ◽  
Molecular Mechanism ◽  
Mechanism Of Action ◽  
Spatial Structures ◽  
Molecular Mechanism Of Action

Diacylfuroxans Are Masked Nitrile Oxides That Inhibit GPX4 Covalently

2019 ◽  
Author(s):  
John Eaton ◽  
Richard A. Ruberto ◽  
Anneke Kramm ◽  
Vasanthi S. Viswanathan ◽  
Stuart Schreiber
Keyword(s):  
Molecular Mechanism ◽  
Mechanism Of Action ◽  
Therapeutic Target ◽  
Biologically Active ◽  
Drug Resistant ◽  
Nitrile Oxides ◽  
Molecular Mechanism Of Action

<div><div><div><p>GPX4 represents a promising yet difficult-to-drug therapeutic target for the treatment of, among others, drug-resistant cancers. While most GPX4 inhibitors rely on a chloroacetamide moiety to modify covalently the protein’s catalytic selenocysteine residue, the discovery and mechanistic elucidation of structurally diverse GPX4-inhibiting molecules has uncovered novel electrophilic warheads that bind and inhibit GPX4. Here we report our discovery that diacylfuroxans can act as masked nitrile oxides that inhibit GPX4 covalently. These observations illuminate a novel molecular mechanism of action for biologically active furoxans and also suggest that nitrile oxides may be uniquely suited to targeting GPX4.</p></div></div></div>

Dietary selenomethionine ameliorates lipopolysaccharide-induced renal inflammatory injury in broilers via regulating the PI3K/AKT pathway to inhibit necroptosis

2021 ◽  
Author(s):  
Yue Zhang ◽  
Xue Qi ◽  
Xiaoming Chen ◽  
Jinxi Zhang ◽  
Wenyue Zhang ◽  
...  
Keyword(s):  
Protective Effect ◽  
Molecular Mechanism ◽  
Mechanism Of Action ◽  
Kidney Tissue ◽  
Akt Pathway ◽  
Inflammatory Injury ◽  
Molecular Mechanism Of Action

We explore the protective effect of dietary SeMet on the kidney tissue of broilers and determine its potential molecular mechanism of action.

Cellular and molecular mechanism of action of raloxifene on vascular tissue

Bone ◽  
2007 ◽  
Vol 41 (6) ◽  
pp. S2
Author(s):  
B Rauschemberger ◽  
P Cutini ◽  
M Sandoval ◽  
N Polini ◽  
V Massheimer
Keyword(s):  
Molecular Mechanism ◽  
Mechanism Of Action ◽  
Vascular Tissue ◽  
Molecular Mechanism Of Action
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