Local Drug Delivery Based Treatment Approaches for Effective Management of Periodontitis

2019 ◽  
Vol 14 (2) ◽  
pp. 135-152 ◽  
Author(s):  
Geeta Aggarwal ◽  
Sonia Verma ◽  
Madhu Gupta ◽  
Manju Nagpal
Keyword(s):  
Drug Delivery ◽  
Periodontal Disease ◽  
Antimicrobial Agents ◽  
Delivery Systems ◽  
Local Delivery ◽  
Local Drug Delivery ◽  
Prolonged Treatment ◽  
Effective Management ◽  
Pocket Depth ◽  
Mechanical Removal

Background: Periodontal disease is an immuno-inflammatory condition of tissues that surround and hold the teeth. It is the disease which succeeds in all races, groups and both genders. Almost 10 to15% of the global population gets suffered from severe periodontitis as per WHO reports. Periodontal disease may likely cause other systemic diseases such as cardiovascular disease and pre-term low birth weight infants. Mechanical removal of plaques and calculus deposits from supra and subgingival environment is the backbone of periodontal treatment till date whereas complete elimination of these deleterious agents is quite unrealistic as the pocket depth increases. Recent Approaches: Recently controlled local drug delivery application is more encouraging in comparison to systemic approach as it mainly targets to enhance the therapeutic efficacy by maintaining site-specificity, avoiding first pass metabolism, reduction in gastrointestinal (GI) side effects and decreasing the dose. Several drugs such as antiseptics and antibiotics alongwith various carriers are being formulated as local drug delivery systems for effective management of the disease. Various local delivery systems reported are fibers, films, strips, compacts, injectables, microparticles, vesicular carriers, gels and nanoparticles. These local carriers provide effective prolonged treatment at the site of infection at reduced doses. This review enlightens detailed pathophysiology and various phases of periodontitis, challenges in treatment of disease and various antimicrobial agents (along with their marketed formulations) used. The main emphasis of the review is to cover all carrier systems developed so far for local delivery application in the effective management of periodontitis, as a patient compliant drug therapy.

scholarly journals Local drug delivery systems for the treatment of periodontal disease.

1991 ◽  
Vol 14 (2) ◽  
pp. 72-81 ◽  
Author(s):  
Kiyotsugu HIGASHI ◽  
Mariko MATSUSHITA ◽  
Katsuhiko MORISAKI ◽  
Shinichi HAYASHI ◽  
Tadanori MAYUMI
Keyword(s):  
Drug Delivery ◽  
Periodontal Disease ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Local Drug Delivery

scholarly journals The use of long-acting drugs for the treatment of periodontitis

2021 ◽  
Vol 105 (1) ◽  
pp. 48-54
Author(s):  
Yu. Sulim ◽  
◽  
O. Petrishin ◽  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Antimicrobial Agents ◽  
Root Surface ◽  
Delivery Systems ◽  
Local Drug Delivery ◽  
Periodontal Pocket ◽  
Universal Method ◽  
Antimicrobial Drugs ◽  
Advantages And Disadvantages

Resume. The most common and universal method of treating periodontitis is periodontal pocket curettage and root surface smoothing (SRP), after which it is important to prevent re-infection of the pocket. For this purpose, antibiotics and other antimicrobial drugs are prescribed. For many years, periodontists have used the systemic administration of high doses of antibiotics during and after the completion of SRP in order to achieve the desired concentration of the drug in the gingival fluid. Such tactics often led to organic complications. In recent years, the method of introducing antimicrobial agents immobilized on natural or synthetic polymers directly into the periodontal pocket has become widespread. Such compositions slowly dissolve on the spot and eventually release the desired drug component. The study analyzes the publications of recent years on the use of controlled release systems of drugs injected into the periodontal pocket. The most common problems that may arise during the application of this method of treatment are analyzed. The advantages and disadvantages of using such systems are indicated. The indications and contraindications for the use of controlled drug delivery systems are considered, data on their comparative clinical efficacy are given. The main dosage forms used for introduction into the periodontal pocket are described, the drugs registered and sold in Ukraine are listed and the data on their therapeutic efficacy. The future prospects of application of this method in periodontology are also considered in the work. Key words: periodontitis treatment, controlled local drug delivery systems, dental gels and films.

scholarly journals Therapeutic effects of local drug delivery systems - PerioChip® in the treatment of periodontal disease

2014 ◽  
Vol 60 (01) ◽  
pp. 3-8
Author(s):  
Liljana Bogdanovska ◽  
Sahmedin Sali ◽  
Mirjana Popovska ◽  
Ilijana Muratovska ◽  
Aneta Dimitrovska ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Periodontal Disease ◽  
Drug Delivery Systems ◽  
Disease Recurrence ◽  
Delivery Systems ◽  
Periodontal Treatment ◽  
Local Drug Delivery ◽  
Therapeutic Effects ◽  
Disease Site ◽  
Low Incidence

The primary goal of periodontal treatment is to stop periodontal disease progression and reduce future risks in disease recurrence. In order to overcome the limitations of the conventional treatment, controlled drug delivery systems for application in periodontal pockets have been developed. Their use offers several advantages: the therapeutic agent is targeted directly to the disease site and concentrations are 10-100 folds higher than the concentrations achieved by systemic administration, with low incidence of side effects. The PerioChip® is as local controlled-release biodegradable delivery system containing chlorhexidine digluconate. Several multicenter clinical trials have shown that the application of the PerioChip® in periodontal pockets as adjunct to the conventional periodontal treatment significantly improved the clinical parameters. In this article, the results from controlled clinical studies aimed to evaluate the clinical and microbiological efficacy of the PerioChip®, are discussed.

scholarly journals A COMPARATIVE STUDY TO ASSES THE EFFICACY OF NANOBIO FUSION GEL AS AN ADJUNCT TO SCALING AND POLISHING IN CHRONIC PERIODONTITIS. - A CLINICAL STUDY

2020 ◽  
pp. 1-3
Author(s):  
Patil A. Veena ◽  
Ansari T. Sobia ◽  
Agarwal Priyanka ◽  
Ayesha Ayesha ◽  
Sultana Shahnaaz
Keyword(s):  
Periodontal Disease ◽  
Chronic Periodontitis ◽  
Antimicrobial Agents ◽  
Test Group ◽  
Controlled Clinical Trial ◽  
Pocket Depth ◽  
Antioxidant Power ◽  
Probing Pocket Depth ◽  
Significant Difference ◽  
And Control

Introduction: Various chemical agents such as nonsteroidal, anti-inflammatory drugs and antimicrobial agents has gained popularity in treatment of periodontal disease but simultaneously lead to condition such as drug resistance and drug allergy. Hence , the topical application of herbal agents such as propolis, aloevera, green tea extracts, Neem reduces the potency and effectiveness to prevent progression of periodontal disease. NanoBioFusion(NBF)gel contains the natural antioxidant power of propolis,vit C,vit E which allows the ultrafine antioxidant to surpase the moist intraoral environment to enter the cells and rejuvenate,revitalize,support,protect and optimize gum and soft oral tissue.Hence the present study is aimed to evaluate the clinical effect of locally delivered NBF gel as an adjunctive therapy to scaling and polishing in the treatment of Periodontitis. Materials and Methods: Chronic Periodontitis patients with 40 sites and probing pocket depth (PD) between 5 and 7 mm were selected in a randomized controlled clinical trial. SRP was performed in both control and test group followed by NBF gel application in 40 sites. The plaque index, gingival index and probing Pocket depth,were recorded at baseline, 6 weeks, and 3 months.The statistical analysis with paired t‑test was used to compare the test and control sites. Results: From baseline to a period of 3 months, a statistically significant difference was seen between both groups for Pocket probing depth and from baseline to 6 weeks the mean GI and PI score have a statistically significant result was obtained(P=0.01& 0.00). Conclusions: Locally delivered NBF gel exhibited a significant improvement compared with SRP alone in chronic periodontitis.

Should local drug delivery systems be used in dentistry?

2021 ◽  
Author(s):  
Joana Vieira Costa ◽  
Jaime Portugal ◽  
Cristina Bettencourt Neves ◽  
Ana F. Bettencourt
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Local Drug Delivery

scholarly journals Surgical Vs Nonsurgical Therapy Adjuncted with Tetracycline Local Drug Delivery in Diabetic Patients: A Randomized Clinical Trial

2015 ◽  
Vol 03 (03) ◽  
pp. 165-173
Author(s):  
Aashutosh Karnik ◽  
Mala Baburaj
Keyword(s):  
Diabetes Mellitus ◽  
Drug Delivery ◽  
Surgical Therapy ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Local Drug Delivery ◽  
Dependent Diabetes Mellitus ◽  
Pocket Depth ◽  
Probing Pocket Depth ◽  
Insulin Dependent

Abstract Objectives: The present study was carried out to determine if non-surgical therapy adjuncted with local drug delivery of tetracycline fibers produces at least optimally comparable results as surgical therapy in non-insulin dependent diabetic individuals with moderate to severe periodontitis. Method and Materials: 80 sites with periodontal pockets measuring 5-8 mm in 40 controlled non-insulin dependent diabetes mellitus patients were treated with either tetracyclinelocal drug deliveryorflap surgery. Measurements of Probing pocket depth and Clinical attachment level at selected sites in each patient along with Plaque Index and Gingival Index were documented at baseline and after 4 weeks, 6 weeks, 9 weeks and 12 weeks post treatment. Results: Both non-surgical therapy adjuncted with local drug delivery and surgical therapy were found to be comparably effectivein reduction of all parameters except Probing Pocket Depth, for which surgical therapy wasstatistically significantly more efficacious(p<0.01), though clinically the difference was insignificant. Conclusions: Within the limits of the study, non-surgical therapy adjuncted with local drug delivery of tetracycline fibers appears to be clinically as efficacious as surgical therapy and may be employed as the preferred therapy for treatment of deep pockets measuring 5-8 mm in controlled non-insulin dependent diabetes mellitus patients.

Local Drug Delivery as an Adjunct to Surgical Intervention in the Management of Periapical Cyst

2017 ◽  
Vol 2 (1) ◽  
pp. 28-31 ◽  
Author(s):  
Anulekh Babu ◽  
P Sajith Chandran ◽  
CU Vivekchand ◽  
Lija I Parackal ◽  
Susan Jacob ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Root Canal ◽  
Antimicrobial Agents ◽  
Surgical Intervention ◽  
Treatment Options ◽  
Local Drug Delivery ◽  
Prolonged Release ◽  
Present Case Report ◽  
Periapical Lesions ◽  
Periapical Cyst

ABSTRACT Radicular cysts are the most common cystic lesions affecting the jaws. They arise from the epithelial remnants in the periodontal ligament as a result of the stimulus from periapical infection following pulpal necrosis. Treatment options to manage large periapical lesions range from nonsurgical root canal treatment or apical surgery to extraction. New approaches involve the use of local drug delivery systems based on microparticles/nanoparticles made from biocompatible polymers along with surgical intervention. Such devices enable the introduction of antimicrobial agents or other drugs directly in the periradicular area or inside the root canal, and the prolonged release of constant concentrations of these agents for fast and better healing. The present case report illustrates the combined endodontic and surgical management of a large periapical cyst with local drug delivery as an adjunct. How to cite this article Chandran PS, Babu A, Vivekchand CU, Parackal LI, Jacob S, Simon D. Local Drug Delivery as an Adjunct to Surgical Intervention in the Management of Periapical Cyst. Cons Dent Endod J 2017;2(1):28-31.

Encapsulation of VEGF165into magnetic PLGA nanocapsules for potential local delivery and bioactivity in human brain endothelial cells

2015 ◽  
Vol 3 (12) ◽  
pp. 2538-2544 ◽  
Author(s):  
E. Carenza ◽  
O. Jordan ◽  
P. Martínez-San Segundo ◽  
R. Jiřík ◽  
Z. Starčuk jr ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Endothelial Cells ◽  
Human Brain ◽  
Targeted Delivery ◽  
Drug Delivery Systems ◽  
Therapeutic Angiogenesis ◽  
Delivery Systems ◽  
Local Delivery ◽  
Brain Endothelial Cells ◽  
Angiogenic Proteins

New drug delivery systems based on biodegradable magnetic nanocapsules for targeted delivery of pro-angiogenic proteins, potentially useful in therapeutic angiogenesis, are reported.

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