Phospholipase Cγ Signaling in Bone Marrow Stem Cell and Relevant Natural Compounds Therapy

2020 ◽  
Vol 15 (7) ◽  
pp. 579-587
Author(s):  
Chang Liu ◽  
Yuan He ◽  
Xiaobing Xu ◽  
Baorong He
Keyword(s):  
Rheumatoid Arthritis ◽  
Stem Cells ◽  
Bone Marrow ◽  
Stem Cell ◽  
Growth Factor ◽  
Bone Resorption ◽  
Signaling Pathways ◽  
Natural Compounds ◽  
Bone Marrow Stem Cell ◽  
Marrow Stem Cell

Excessive bone resorption has been recognized play a major role in the development of bone-related diseases such as osteoporosis, rheumatoid arthritis, Paget's disease of bone, and cancer. Phospholipase Cγ (PLCγ) family members PLCγ1 and PLCγ2 are critical regulators of signaling pathways downstream of growth factor receptors, integrins, and immune complexes and play a crucial role in osteoclast. Ca2+ signaling has been recognized as an essential pathway to the differentiation of osteoclasts. With growing attention and research about natural occurring compounds, the therapeutic use of natural active plant-derived products has been widely recognized in recent years. In this review, we summarized the recent research on PLCγ signaling in bone marrow stem cells and the use of several natural compounds that were proven to inhibit RANKL-mediated osteoclastogenesis via modulating PLCγ signaling pathways.

scholarly journals Mechanism and Treatment Strategy of Osteoporosis after Transplantation

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Lei Song ◽  
Xu-Biao Xie ◽  
Long-Kai Peng ◽  
Shao-Jie Yu ◽  
Ya-Ting Peng
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Bone Resorption ◽  
Bone Loss ◽  
Bone Formation ◽  
Organ Transplant ◽  
Bone Marrow Stem Cell ◽  
Age And Gender ◽  
And Gender ◽  
Marrow Stem Cell

Osteoporosis (OP) has emerged as a frequent and devastating complication of organ solid transplantation process. Bone loss after organ transplant is related to adverse effects of immunosuppressants on bone remodeling and bone quality. Many factors contribute to the pathogenesis of OP in transplanted patients. Many mechanisms of OP have been deeply approached. Drugs for OP can be generally divided into “bone resorption inhibitors” and “bone formation accelerators,” the former hindering bone resorption by osteoclasts and the latter increasing bone formation by osteoblasts. Currently, bisphosphonates, which are bone resorption inhibitors drugs, are more commonly used clinically than others. Using the signaling pathway or implantation bone marrow stem cell provides a novel direction for the treatment of OP, especially OP after transplantation. This review addresses the mechanism of OP and its correlation with organ transplantation, lists prevention and management of bone loss in the transplant recipient, and discusses the recipients of different age and gender.

Effect of Conditioned Medium and Bone Marrow Stem Cell Lysate on the Course of Acetaminophen-Induced Liver Failure

2015 ◽  
Vol 159 (1) ◽  
pp. 118-123 ◽  
Author(s):  
M. Sh. Khubutiya ◽  
A. A. Temnov ◽  
V. A. Vagabov ◽  
A. N. Sklifas ◽  
K. A. Rogov ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Liver Failure ◽  
Conditioned Medium ◽  
Bone Marrow Stem Cell ◽  
Cell Lysate ◽  
Marrow Stem Cell
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