A Promising Anti-Cancer and Anti-Oxidant Agents Based on the Pyrrole and Fused Pyrrole: Synthesis, Docking Studies and Biological Evaluation

2015 ◽  
Vol 15 (4) ◽  
pp. 517-526 ◽  
Author(s):  
Samar Fatahala ◽  
Emad Shalaby ◽  
Shaymaa Kassab ◽  
Mossad Mohamed
Keyword(s):  
Docking Studies ◽  
Biological Evaluation ◽  
Anti Cancer ◽  
Anti Oxidant

CORRIGENDUM A Promising Anti-Cancer and Anti-Oxidant Agents Based on the Pyrrole and Fused Pyrrole: Synthesis, Docking Studies and Biological Evaluation

2019 ◽  
Vol 18 (10) ◽  
pp. 1505-1505
Keyword(s):  
Medicinal Chemistry ◽  
Docking Studies ◽  
Biological Evaluation ◽  
Anti Cancer ◽  
Anti Oxidant

Due to an oversight, one of the author’s name was published wrong in the article entitled “A Promising Anti-Cancer and Anti-Oxidant Agents Based on the Pyrrole and Fused Pyrrole: Synthesis, Docking Studies and Biological Evaluation” in “Anti-Cancer Agents in Medicinal Chemistry, 2015, Vol. 15, No. 4, pp. 517.” The correct names of all authors are given below: Samar Said Fatahala*, Emad Ahmed Shalaby, Shaymaa Emam Kassab and Mossad Said Mohamed to Mossad Sayed Mohamed

Anti-cancer, anti-oxidant and molecular docking studies of thiosemicarbazone indole-based derivatives

2019 ◽  
Vol 45 (5) ◽  
pp. 2827-2854 ◽  
Author(s):  
Zohreh Bakherad ◽  
Maliheh Safavi ◽  
Afshin Fassihi ◽  
Hojjat Sadeghi-Aliabadi ◽  
Mohammad Bakherad ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Docking Studies ◽  
Molecular Docking Studies ◽  
Anti Cancer ◽  
Anti Oxidant

Synthesis of pyrimidine-2,4,6-trione derivatives: Anti-oxidant, anti-cancer, α-glucosidase, β-glucuronidase inhibition and their molecular docking studies

2016 ◽  
Vol 68 ◽  
pp. 72-79 ◽  
Author(s):  
Assem Barakat ◽  
Mohammad Shahidul Islam ◽  
Abdullah Mohammed Al-Majid ◽  
Hazem A. Ghabbour ◽  
Sammer Yousuf ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Docking Studies ◽  
Molecular Docking Studies ◽  
Anti Cancer ◽  
Anti Oxidant

scholarly journals Docking studies and biological evaluation of anti-cancer activity of new 1,2,4 – trіаzоle(4h)derivatives

2014 ◽  
Vol 1 (2) ◽  
pp. 46 ◽  
Author(s):  
Victoriya Georgiyants ◽  
Lina Perekhoda ◽  
Narzullo Saidov ◽  
Idibeg Kadamov
Keyword(s):  
Docking Studies ◽  
Biological Evaluation ◽  
Anti Cancer ◽  
Cancer Activity

scholarly journals Luteolin: A Dietary Molecule as Potential Anti-COVID-19 Agent

2020 ◽  
Author(s):  
Waseem Ahmad Ansari ◽  
Tanveer Ahamad ◽  
Mohsin Ali Khan ◽  
Zaw Ali Khan ◽  
Mohammad Faheem Khan
Keyword(s):  
Docking Studies ◽  
Inflammatory Agent ◽  
Adequate Amount ◽  
Main Protease ◽  
Regular Consumption ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Proteinase A ◽  
Anti Inflammatory ◽  
Potential Use

Abstract Luteolin (Lut) is an important plant-derived flavonoid that is widely distributed in edible herbs and vegetables. Studies on animal and human models have shown that Lut exhibits various pharmacological properties, viz. anti-inflammatory, anti-cancer, anti-oxidant, anti-apoptotic, and neurotrophic actions. The ongoing pandemic coronavirus disease-2019 (COVID-19), is a disease of the respiratory tract that consists of mild to severe symptoms of pneumonia including fever, muscle aches, sore throat, coughing, and shortness of breath. It is of particular concern in older people and patients with chronic diseases having cardiovascular and blood clotting issues or who have compromised immune. This situation prompted us to evaluate the bioactive compounds which are being used to prevent respiratory-related illness. Lut is one such compound which is used as an anti-inflammatory agent. Several studies have explained the protective nature of Lut by inhibiting virus entry and fusion with human receptors in old SARS-CoV that had emerged in 2003. Thus, regular consumption of foods having adequate amount of Lut in our diet may be helpful in inhibiting the SARS-CoV-2 infection as well and may prevent the consequent symptoms in COVID-19 patients. In present work, we have carried out the molecular docking studies of Lut with six different SARS-CoV-2 encoded key proteins. The FDA-approved drug remdesivir was also evaluated as control to compare the results. Lut showed excellent inhibitory action against papain-like proteinase, a main protease of SARS-CoV-2. Lut was also many times more active than remdesivir. Therefore, the foods which have Lut in adequate amount might be explored further for potential use against COVID-19

Role of Rasayan Churna in outbreak of Covid -19 as preventive and curative aspect

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1208-1212
Author(s):  
Amol Madhav Deshpande ◽  
Mayuri Amol Deshpande
Keyword(s):  
Recurrent Infection ◽  
Symptomatic Patient ◽  
H1n1 Influenza ◽  
Drug Of Choice ◽  
Asymptomatic Patients ◽  
Diseased Person ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Immune Booster ◽  
Respiratory Droplets

In last two decade world suffer with three epidemic diseases like SARS-CoV, H1N1 influenza, MERS –CoV and presently the world under a pandemic of Covid-19, out of these SARS-CoV, MERS –CoV and Covid-19 are form the same virus call as corona, which primary present on bats and transferred from animal to human, and then it transfer from human to human mostly by respiratory droplets or in the direct contact with the diseased person, these recurrent infection of corona virus is the burning issue in the word, so to avoid these recurrent infections good habitual behaviour with regular immune booster medicine should be taken which can be used in both normal and symptomatic patient for this Rasayan churna  is the best drug of choice as it is used for  rejuvenation therapy. From literally study from various recourses it is found that Rasayan churna have property anti-depressant, anti-xylotic, Immunomodulatory, Anti-diabetes, anti hypertensive, anti-inflammatory, Anti-toxic effects, Anti-arthritic, Anti-cancer effects, Anti-microbial effect, and Anti-oxidant which can be useful in preventive aspect of Covid -19 in all phase like normal individual, also can be used in asymptomatic patients and symptomatic patients, clinical study can be performed for the same to evaluate the result.

1,4-Dihydropyridine: A Dependable Heterocyclic Ring with the Promising and the Most Anticipable Therapeutic Effects

2019 ◽  
Vol 19 (15) ◽  
pp. 1219-1254 ◽  
Author(s):  
Abhinav Prasoon Mishra ◽  
Ankit Bajpai ◽  
Awani Kumar Rai
Keyword(s):  
Calcium Ion ◽  
Heterocyclic Compounds ◽  
Channel Blocker ◽  
Heterocyclic Ring ◽  
Therapeutic Effects ◽  
Voltage Gated ◽  
Therapeutic Benefits ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Synthetic Medicinal

: Nowadays, heterocyclic compounds act as a scaffold and are the backbone of medicinal chemistry. Among all of the heterocyclic scaffolds, 1,4-Dihydropyridine (1,4-DHP) is one of the most important heterocyclic rings that possess prominent therapeutic effects in a very versatile manner and plays an important role in synthetic, medicinal, and bioorganic chemistry. The main aim of the study is to review and encompass relevant studies related to 1,4-DHP and excellent therapeutic benefits of its derivatives. An extensive review of Pubmed-Medline, Embase and Lancet’s published articles was done to find all relevant studies on the activity of 1,4-DHP and its derivatives. 1,4-DHP is a potent Voltage-Gated Calcium Channel (VGCC) antagonist derivative which acts as an anti-hypertensive, anti- anginal, anti-tumor, anti-inflammatory, anti-tubercular, anti-cancer, anti-hyperplasia, anti-mutagenic, anti-dyslipidemic, and anti-ulcer agent. From the inferences of the study, it can be concluded that the basic nucleus, 1,4-DHP which is a voltage-gated calcium ion channel blocker, acts as a base for its derivatives that possess different important therapeutic effects. There is a need of further research of this basic nucleus as it is a multifunctional moiety, on which addition of different groups can yield a better drug for its other activities such as anti-convulsant, anti-oxidant, anti-mutagenic, and anti-microbial. This review would be significant for further researches in the development of several kinds of drugs by representing successful matrix for the medicinal agents.

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