Oleocanthal, a Natural anti-Inflammatory Compound in Extra Virgin Olive Oil

2010 ◽  
Vol 9 (2) ◽  
pp. 94-100 ◽  
Author(s):  
Sara Cicerale ◽  
Russell S.J. Keast
Keyword(s):  
Olive Oil ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil ◽  
Anti Inflammatory

scholarly journals Extra Virgin Olive Oil Extracts Modulate the Inflammatory Ability of Murine Dendritic Cells Based on Their Polyphenols Pattern: Correlation between Chemical Composition and Biological Function

Antioxidants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1016
Author(s):  
Stefania De Santis ◽  
Marina Liso ◽  
Giulio Verna ◽  
Francesca Curci ◽  
Gualtiero Milani ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Olive Oil ◽  
Virgin Olive Oil ◽  
Adaptive Immune Response ◽  
Extra Virgin Olive Oil ◽  
Pattern Correlation ◽  
Important Health ◽  
Health Promoting ◽  
Anti Inflammatory ◽  
Inflammatory Profile

Extra virgin olive oil (EVOO) represents one of the most important health-promoting foods whose antioxidant and anti-inflammatory activities are mainly associated to its polyphenols content. To date, studies exploring the effect of EVOO polyphenols on dendritic cells (DCs), acting as a crosstalk between the innate and the adaptive immune response, are scanty. Therefore, we studied the ability of three EVOO extracts (cv. Coratina, Cima di Mola/Coratina, and Casaliva), characterized by different polyphenols amount, to regulate DCs maturation in resting conditions or after an inflammatory stimulus. Cima di Mola/Coratina and Casaliva extracts were demonstrated to be the most effective in modulating DCs toward an anti-inflammatory profile by reduction of TNF and IL-6 secretion and CD86 expression, along with a down-modulation of Il-1β and iNOS expression. From factorial analysis results, 9 polyphenols were tentatively established to play a synergistic role in modulating DCs inflammatory ability, thus reducing the risk of chronic inflammation.

Anti-inflammatory and joint protective effects of extra-virgin olive-oil polyphenol extract in experimental arthritis

2014 ◽  
Vol 25 (12) ◽  
pp. 1275-1281 ◽  
Author(s):  
María Ángeles Rosillo ◽  
María José Alcaraz ◽  
Marina Sánchez-Hidalgo ◽  
José G. Fernández-Bolaños ◽  
Catalina Alarcón-de-la-Lastra ◽  
...  
Keyword(s):  
Olive Oil ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil ◽  
Experimental Arthritis ◽  
Protective Effects ◽  
Anti Inflammatory

Retraction notice to Polar and apolar extra virgin olive oil and leaf extracts as a promising anti-inflammatory natural treatment for osteoarthritis. ACTHIS_119_4 (2017) 407-416

2018 ◽  
Vol 120 (1) ◽  
pp. 64
Author(s):  
Houda Nsir ◽  
Marta Anna Szychlinska ◽  
Venera Cardile ◽  
Adriana Carol Eleonora Graziano ◽  
Rosanna Avola ◽  
...  
Keyword(s):  
Olive Oil ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil ◽  
Leaf Extracts ◽  
Natural Treatment ◽  
Anti Inflammatory ◽  
Retraction Notice

scholarly journals Analgesic, Anti-Inflammatory and Anticancer Activities of Extra Virgin Olive Oil

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Myriam Fezai ◽  
Laura Senovilla ◽  
Mohamed Jemaà ◽  
Mossadok Ben-Attia
Keyword(s):  
Acetic Acid ◽  
Acetylsalicylic Acid ◽  
Olive Oil ◽  
Virgin Olive Oil ◽  
Intraperitoneal Administration ◽  
Xenograft Model ◽  
Extra Virgin Olive Oil ◽  
Athymic Mice ◽  
Anti Inflammatory

Background. In folk medicine, extra virgin olive oil (EVOO) is used as a remedy for a variety of diseases. This study investigates thein vivoantinociceptive, anti-inflammatory, and anti-cancer effects of EVOO on mice and rats.Materials and Methods. In this experimental study, using the acetic acid-induced writhing and formalin tests in mice, the analgesic effect of EVOO was evaluated. Acetylsalicylic acid and morphine were used as standard drugs, respectively. The anti-inflammatory activity was investigated by means of the carrageenan-induced paw edema model in rats using acetylsalicylic acid and dexamethasone as standard drugs. Last, the xenograft model in athymic mice was used to evaluate the anticancer effectin vivo.Results. EVOO significantly decreased acetic acid-induced abdominal writhes and reduces acute and inflammatory pain in the two phases of the formalin test. It has also a better effect than Dexamethasone in the anti-inflammatory test. Finally, the intraperitoneal administration of EVOO affects the growth of HCT 116 tumours xenografted in athymic mice.Conclusion. EVOO has a significant analgesic, anti-inflammatory, and anticancer properties. However, further detailed studies are required to determine the active component responsible for these effects and mechanism pathway.

scholarly journals Extra-virgin olive oil consumption reduces the age-related decrease in HDL and paraoxonase 1 anti-inflammatory activities

2013 ◽  
Vol 110 (7) ◽  
pp. 1272-1284 ◽  
Author(s):  
Soumaya Loued ◽  
Hicham Berrougui ◽  
Pamela Componova ◽  
Souad Ikhlef ◽  
Olfa Helal ◽  
...  
Keyword(s):  
Olive Oil ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil ◽  
Inflammatory Activity ◽  
Paraoxonase 1 ◽  
Conjugated Diene ◽  
Leukaemia Cell Line ◽  
Age Related ◽  
Anti Inflammatory

Paraoxonase 1 (PON1) is associated with HDL and modulates the antioxidant and anti-inflammatory role of HDL. The goals of the present study were to investigate the effect of ageing and the role of PON1 on the anti-inflammatory activity of HDL, and to determine whether extra-virgin olive oil (EVOO) consumption could improve the atheroprotective activity of HDL. HDL and PON1 were isolated from the plasma of ten young (Y-HDL and Y-PON1) and ten elderly (E-HDL and E-PON1) healthy volunteers before and after 12 weeks of EVOO consumption. Inflammation was assessed by measuring intracellular adhesion molecule 1 (ICAM-1) expression. THP-1 (human acute monocytic leukaemia cell line) monocyte chemotaxis was measured using a Boyden chamber. Oxidative damage to HDL was assessed by measuring conjugated diene formation and changes in electrophoretic migration. Y-HDL had more anti-inflammatory activity than E-HDL. The conjugated diene content and the electrophoretic mobility of E-HDL were higher than those of Y-HDL. Y-PON1 had significant anti-inflammatory activity, reducing ICAM-1 expression by 32·64 (sd 2·63) %, while E-PON1 had no significant effect. THP-1 chemotaxis measurements confirmed the ICAM-1 expression results. The 12 weeks of EVOO consumption significantly increased the anti-inflammatory activities of both HDL and PON1. The anti-inflammatory activity of HDL was modulated by PON1 and was lower in the elderly volunteers. EVOO consumption increased the anti-inflammatory effect of HDL and reduced the age-related decrease in anti-atherogenic activity.

Evaluation of dialdehydic anti-inflammatory active principles in extra-virgin olive oil by reactive paper spray mass spectrometry

2013 ◽  
Vol 352 ◽  
pp. 87-91 ◽  
Author(s):  
Fabio Mazzotti ◽  
Leonardo Di Donna ◽  
Domenico Taverna ◽  
Monica Nardi ◽  
Donatella Aiello ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Olive Oil ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil ◽  
Paper Spray ◽  
Anti Inflammatory
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