Characterization of Mitogen-Activated Protein Kinase Expression in Nucleus Accumbens and Hippocampus of Rats Subjected to Food Selection in the Cafeteria Diet Protocol

2016 ◽  
Vol 15 (7) ◽  
pp. 866-872
Author(s):  
Andrea Sarro-Ramírez ◽  
Daniel Sánchez ◽  
Alma Tejeda-Padrón ◽  
Linda Vianey Buenfil-Canto ◽  
Jorge Valladares-García ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Protein Kinase ◽  
Food Selection ◽  
Cafeteria Diet ◽  
Mitogen Activated Protein Kinase ◽  
Mitogen Activated Protein ◽  
Kinase Expression

scholarly journals Molecular Cloning and Characterization of a Novel p38 Mitogen-activated Protein Kinase

1997 ◽  
Vol 272 (38) ◽  
pp. 23668-23674 ◽  
Author(s):  
Xuhong Sunny Wang ◽  
Katrina Diener ◽  
Carl L. Manthey ◽  
Shen-wu Wang ◽  
Bradley Rosenzweig ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Molecular Cloning ◽  
Mitogen Activated Protein Kinase ◽  
Mitogen Activated Protein

Exercise-associated differences in an array of proteins involved in signal transduction and glucose transport

2001 ◽  
Vol 90 (1) ◽  
pp. 29-34 ◽  
Author(s):  
Mei Yu ◽  
Eva Blomstrand ◽  
Alexander V. Chibalin ◽  
Harriet Wallberg-Henriksson ◽  
Juleen R. Zierath ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Protein Kinase ◽  
Insulin Receptor ◽  
Insulin Signaling ◽  
Mitogen Activated Protein Kinase ◽  
Signaling Cascade ◽  
Vastus Lateralis Muscle ◽  
Glut 4 ◽  
Mitogen Activated Protein ◽  
Kinase Expression

Vastus lateralis muscle biopsies were obtained from endurance-trained (running ∼50 km/wk) and untrained (no regular physical exercise) men, and the expression of an array of insulin-signaling intermediates was determined. Expression of insulin receptor and insulin receptor substrate-1 and -2 was decreased 44% ( P < 0.05), 57% ( P < 0.001), and 77% ( P < 0.001), respectively, in trained vs. untrained muscle. The downstream signaling target, Akt kinase, was not altered in trained subjects. Components of the mitogenic signaling cascade were also assessed. Extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase expression was 190% greater ( P < 0.05), whereas p38 mitogen-activated protein kinase expression was 32% lower ( P < 0.05), in trained vs. untrained muscle. GLUT-4 protein expression was twofold higher ( P < 0.05), and the GLUT-4 vesicle-associated protein, the insulin-regulated aminopeptidase, was increased 4.7-fold ( P < 0.05) in trained muscle. In conclusion, the expression of proteins involved in signal transduction is altered in skeletal muscle from well-trained athletes. Downregulation of early components of the insulin-signaling cascade may occur in response to increased insulin sensitivity associated with endurance training.

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