A Review On Hematopoietic Stem Cell Treatment For Epilepsy

2021 ◽  
Vol 20 ◽  
Author(s):  
Mohan Krishna Ghanta ◽  
Neha Merchant ◽  
L.V.K.S. Bhaskar
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Mechanism Of Action ◽  
Refractory Epilepsy ◽  
Clinical Effects ◽  
Neuronal Regeneration ◽  
Hematopoietic Stem ◽  
Treatment Of Epilepsy ◽  
Stem Cell Treatment ◽  
New Strategies

: Epilepsy responds to pharmacotherapy in its initial stages. The response of some forms of epilepsy like the refractory epilepsy is extremely low. Surgical management of epilepsy is associated with complications, which necessitates the search for novel and modern strategies for the treatment of epilepsy. Neuroprotection and neuronal regeneration are the major targets that must be accomplished by the new strategies. Hematopoietic stem cell (HSCs) therapy for epilepsy has shown promising results in pre-clinical studies with marginal clinical effects. This review explores the characteristics, mechanism of action, and clinical significance of HSCs therapy for the treatment of epilepsy.

Clinical Effects of COVID-19 on Hematopoietic Stem Cell Transplant Outcomes in Pediatric Patients

2021 ◽  
Vol 19 (5) ◽  
pp. 501-507
Author(s):  
Dima Barhoom ◽  
Rashin Mohseni ◽  
Amir Ali Hamidieh ◽  
Masoud Mohammadpour ◽  
Meisam Sharifzadeh ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem Cell Transplant ◽  
Pediatric Patients ◽  
Stem Cell Transplant ◽  
Cell Transplant ◽  
Clinical Effects ◽  
Hematopoietic Stem ◽  
Transplant Outcomes

scholarly journals Tailored Exercise during Hematopoietic Stem Cell Transplantation Hospitalization in Children with Cancer: A Prospective Cohort Study

Cancers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 3020
Author(s):  
Javier S. Morales ◽  
Marta González Vicent ◽  
Pedro L. Valenzuela ◽  
Adrián Castillo-García ◽  
Elena Santana-Sosa ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Graft Failure ◽  
Viral Infections ◽  
Clinical Effects ◽  
Inpatient Hospitalization ◽  
Hematopoietic Stem

We assessed the clinical effects of a supervised exercise (aerobic + resistance) intervention performed during inpatient hospitalization for pediatric hematopoietic stem cell transplantation (HSCT). Patients were placed in an exercise (n = 65 (47 and 18 with allogeneic (allo-) and autologous (auto-) HSCT, respectively)) or a control (n = 53 (39 and 14)) group. Exercise interventions were performed in isolated hospital patient rooms. Patients were followed-up from the beginning of the conditioning phase up to 6 years. We assessed survival, risk of graft-versus-host disease (GvHD) or graft failure (primary outcomes), and engraftment kinetics, supportive care, toxicity profile, and immune reconstitution for auto-HSCT and allo-HSCT. The exercise intervention was safe and did not affect the risk of mortality, acute/chronic GvHD, or graft failure (all p > 0.05). No between-group differences (p > 0.05) were found for the remainder of clinical endpoints, except for a reduced number of total and viral infections in the exercise group after allo-HSCT (unadjusted p = 0.005 for both total and viral infections, and adjusted p = 0.023 and 0.083, respectively). In conclusion, exercise performed during inpatient hospitalization for pediatric HSCT is safe and well tolerated during both auto and allo-HSCT and tends to decrease the risk of infection after allo-HSCT. These findings provide additional support to the notion that a multidisciplinary approach (i.e., including the work of exercise specialists) is suitable in the management of children undergoing HSCT. Further studies are needed to determine whether applying a different training stimulus (notably, higher exercise intensities) exerts positive effects on HSCT prognosis in these patients.

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